DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad88C and CDHR2

DIOPT Version :10

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:NP_060145.3 Gene:CDHR2 / 54825 HGNCID:18231 Length:1310 Species:Homo sapiens


Alignment Length:1482 Identity:408/1482 - (27%)
Similarity:617/1482 - (41%) Gaps:357/1482 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 ISSISIQVIILTTLISLVASNRPPRFAIDGQSEIVLRLKESPE-TKVGTLIYTLKGYDPDNDPLT 99
            ::.:.:...:|..|:..||:|..|:|..:..|.|:      || ..||...:.|...|.||||||
Human     1 MAQLWLSCFLLPALVVSVAANVAPKFLANMTSVIL------PEDLPVGAQAFWLVAEDQDNDPLT 59

  Fly   100 FGKRNSHDSEIIRIENTGGNEAKIFLAKELDRELQDEYAIVLTLTDSHYSDHNYVTQSFLLLVED 164
            :|....:.........||    ::.||..||.|....:.:.::::|.:..    |.:..|::|||
Human    60 YGMSGPNAYFFAVTPKTG----EVKLASALDYETLYTFKVTISVSDPYIQ----VQREMLVIVED 116

  Fly   165 INDNVPTFLPYQNAI-------EIPEGSAPGVVSTLEATDADEGAYGQVVYYLQEL---DGDND- 218
            .|||.|.|   ||..       .:|.||   ||.::.|.|.|.|:.|.|||.::::   .||:: 
Human   117 RNDNAPVF---QNTAFSTSINETLPVGS---VVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEH 175

  Fly   219 VFSIATHQGKGILRLQKELDYERKS-LYQLRVLAIDRA----NQGPINTGTAAIL-VKVKDLEDQ 277
            :|.|..:   |.:.|...|.|..|| .|||.:.|.|..    |...|.......| :.|.|..|.
Human   176 LFRILAN---GSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDL 237

  Fly   278 PPEFVEVQAVARIAEDAPVGTKVLRVRAIDGDRGINNPIAYSLEAN---DLFDINPHTGIVHTLT 339
            .|:||.....|.:||||..||.||.|.|:|||:|||:|:.||:..:   ..|||.. .|::....
Human   238 DPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGA-DGVIRVNG 301

  Fly   340 KLDRE---EQSDQVNGAHILRISATELSKSNTQMAPTTVRTEVTVIVSDVNDEIPTFGETVYRCE 401
            .||||   |..::|.    |:::||| :..|.......|...|||.|.||||..|.|    |.|.
Human   302 SLDREQLLEADEEVQ----LQVTATE-THLNIYGQEAKVSIWVTVRVMDVNDHKPEF----YNCS 357

  Fly   402 V------NENAQTNTPLNFIDE---------EVQNVVFDHDEGNNGTFRLFLDPPN-DLFEIVPE 450
            :      .|.||.|. ..::||         ::..||:|.|:|:||||.|.|..|: :.|.:.||
Human   358 LPACTFTPEEAQVNF-TGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPE 421

  Fly   451 LAVNEANFMLRVKNSKSLDFEQFTEVNFTIFAREVDEPSR-WSSAHVQIFIRDQNDNFPEFSQTI 514
            .||..|:..:.|:.|..:|:|:.|.:...:.|  .|..|: :|.|.|.|.:||.||:.|.|.|::
Human   422 RAVGSASVQVLVRVSALVDYERQTAMAVQVVA--TDSVSQNFSVAMVTIHLRDINDHRPTFPQSL 484

  Fly   515 YNASVLENSEQDTIIT-HVQAVDVDSGDYGTMGIRYTNLRGGIAHLLNLNPITGVITIKQAGGTA 578
            |..:|.|:|...:::| .:.|.|.|:|.:|.  |.|:.|.|..|.|..::|::|.:|::  .|..
Human   485 YVLTVPEHSATGSVVTDSIHATDPDTGAWGQ--ITYSLLPGNGADLFQVDPVSGTVTVR--NGEL 545

  Fly   579 FDREIISRHYLTVEAIDNAGQGNRNTAQIIVDILDVNDNAPTFPQRQYETKLLENQAEFETPLQL 643
            .|||..:.:|||::|.|.....:..|.||  .:||:|||||.. ...|...:.|.:......:| 
Human   546 LDRESQAVYYLTLQATDGGNLSSSTTLQI--HLLDINDNAPVV-SGSYNIFVQEEEGNVSVTIQ- 606

  Fly   644 EARDADLNGTENSQVTYEIVEGLYRSNFTIDPQSGLLRPVHSFDFEELVDGSSRRSDPYTGGSFS 708
             |.|.|..||.||::.:.::.|.|..||::||.:||||.:...|.|.:        ||...|   
Human   607 -AHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAI--------DPALEG--- 659

  Fly   709 IREIDLLVRARDSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFYAKTVPEDLPGGSSVL--QVTAI 771
              .|.|.|...|.|.|:|.|.|.|.|.|:|:|||.|||.||.|..||.|:.||   ||  .|.|.
Human   660 --RIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPG---VLVGVVKAW 719

  Fly   772 DRDGSAPNNVVVYRIQTGAGDKFIINSETGVISVAHGA----NLDPD--LTESKRSLYTLSVIAL 830
            |.|.:..||.:.:.:.....:.|:|.   |::..|..|    .|.||  |....:.::.|:|.|.
Human   720 DADQTEANNRISFSLSGSGANYFMIR---GLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAE 781

  Fly   831 D-GGLGNSQLMTTCTVNISIQDVNNKPPVL--KEMPALQILENTPVGTLVYRIQATDLDHKAILR 892
            : ...|...::..|   ::::|||:.||.|  ..:..:::.||......|..:.|:|:|..|.|.
Human   782 NPDPQGGETIVDVC---VNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLE 843

  Fly   893 YKLNPEHCEGRTEEGALVKSSEYDFLGAFEVDSIEGTLKVVKLLDRERVEHIKLAITVEDLAAAK 957
            .:|....|   |:.|..|.|                                             
Human   844 IQLVNILC---TKAGVDVGS--------------------------------------------- 860

  Fly   958 GRQIAEGFLSIQVLDENDNNPKFRLPFYRQSITENSINGAMIVNVLASDVDKNRTITYALEGNPT 1022
               :..|:.|:                        :.||::.:|                     
Human   861 ---LCWGWFSV------------------------AANGSVYIN--------------------- 877

  Fly  1023 YRSLMHLDPQTGEIVVASKIDHEQHQWLNFSVR----ATDSGIPARSSLVDVYITVLDENDNNPY 1083
                           .:..||:|....:...||    |||.|..|.|:...:.||:.|.|||.||
Human   878 ---------------QSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPY 927

  Fly  1084 FVGGSKNYT-ISENAAPGTRVATLQAGDADSGDFGKITFLMDR----------ISSQGKFTI--- 1134
            |:..:|.:. |.|...|...||:::|.|.|||:.|.|.|.:.|          |..||.|:|   
Human   928 FLPENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTS 992

  Fly  1135 ---DADTGVLTVADRLDRESKDSYNLVIEAWDNYQFG-FL-AGESRNAF--KQVFISILDENDNP 1192
               |...|.:.....||...:.:|.:.::|.|....| || |..:.|.|  .|.:.|.|..:...
Human   993 SEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPK 1057

  Fly  1193 PEVDLPMSCV--LITEYHELHERVASIVGKDADDPTTPNGRLD--------FAIT--------RG 1239
            .||......:  .:|:.......:..|...|:.....|:..||        .|:|        |.
Human  1058 EEVGANRQAINAALTQATRTTVYIVDIQDIDSAARARPHSYLDAYFVFPNGSALTLDELSVMIRN 1122

  Fly  1240 NKDGMFELRQI---------------------------------------------DAWNAQIFA 1259
            ::|.:.:|.|:                                             .::|.::.|
Human  1123 DQDSLTQLLQLGLVVLGSQESQESDLSKQLISVIIGLGVALLLVLVIMTMAFVCVRKSYNRKLQA 1187

  Fly  1260 SKSLR-------------------NRY----GNYSLTITTRDMGLPANIVHNTLD-ICVSDFNDH 1300
            .|:.:                   |.|    .|..|.:..:|:||......|.|| :.|:..:|:
Human  1188 MKAAKEARKTAAGVMPSAPAIPGTNMYNTERANPMLNLPNKDLGLEYLSPSNDLDSVSVNSLDDN 1252

  Fly  1301 APVFV----------RPLHNTTVRIPENATVGTLILQAYAS---DGDMGQNA 1339
            : |.|          ||.|......||..:|..|..||.||   :|....||
Human  1253 S-VDVDKNSQEIKEHRPPHTPPEPDPEPLSVVLLGRQAGASGQLEGPSYTNA 1303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637 27/92 (29%)
Cadherin_repeat 179..276 CDD:206637 33/113 (29%)
Cadherin_repeat 287..388 CDD:206637 42/106 (40%)
Cadherin_repeat 397..506 CDD:206637 41/125 (33%)
Cadherin_repeat 514..617 CDD:206637 34/103 (33%)
Cadherin_repeat 625..742 CDD:206637 39/116 (34%)
Cadherin_repeat 751..853 CDD:206637 29/110 (26%)
Cadherin_repeat 865..976 CDD:206637 16/110 (15%)
Cadherin_repeat 985..1080 CDD:206637 18/98 (18%)
Cadherin_repeat 1090..1191 CDD:206637 35/121 (29%)
CA 1221..1302 CDD:214520 25/165 (15%)
Cadherin_repeat 1312..1409 CDD:206637 11/31 (35%)
Cadherin_repeat 1418..>1502 CDD:206637
Cadherin_repeat 1617..1710 CDD:206637
CDHR2NP_060145.3 Cadherin_repeat 32..120 CDD:206637 29/101 (29%)
Cadherin_repeat 129..236 CDD:206637 33/112 (29%)
Cadherin_repeat 246..349 CDD:206637 43/108 (40%)
Cadherin_repeat 372..476 CDD:206637 35/106 (33%)
Cadherin_repeat 485..582 CDD:206637 34/102 (33%)
Cadherin_repeat 589..691 CDD:206637 39/116 (34%)
Cadherin_repeat 699..804 CDD:206637 31/113 (27%)
CA <864..926 CDD:214520 22/121 (18%)
Cadherin_repeat 935..1044 CDD:206637 32/108 (30%)
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000269|PubMed:24725409 1180..1310 31/125 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1259..1310 14/45 (31%)
Blue background indicates that the domain is not in the aligned region.

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