DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad88C and Cad96Cb

DIOPT Version :9

Sequence 1:	NP_731930.3	Gene:	Cad88C / 41774	FlyBaseID:	FBgn0038247	Length:	1981	Species:	Drosophila melanogaster
Sequence 2:	NP_001287524.1	Gene:	Cad96Cb / 43033	FlyBaseID:	FBgn0039294	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	849	Identity:	182/849 - (21%)
Similarity:	309/849 - (36%)	Gaps:	279/849 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ILTTLISLVASNRPPRFAI---------DGQSEIVLRLKESPETKVGTLIYTLKGYDPDNDPLTF 100
            |...::||...|:....||         .|.:|..|   .:.:..||::|..|:         ..
  Fly     8 IYYAILSLCWFNKATLGAILDSRCYLEGGGSAESFL---ATEDLAVGSIIGKLR---------IN 60

  Fly   101 GKRNSHDSEI---IRIENT------GGNEAKIFLAKELDRE----LQDEYAIVLTLTDSHYSDHN 152
            |..|:...:|   :|.:|.      |..|  :.|:.|||:|    ....|..|:.:. .|.:|.:
  Fly    61 GDANAETGDINLSLREKNAPVEIHPGTKE--LALSVELDKEGVRGPSSIYVNVICIR-RHSTDPS 122

  Fly   153 YVTQSFLLLVEDINDNVPTFLPYQNAIEIPEGSAPG--VVSTLEATDADE-------------GA 202
            :|. ...:.|.|:|||.|.::.....:.:.|.:.||  ::....|.|||:             |.
  Fly   123 FVI-PVNVRVTDVNDNAPQWIGTPYTLTLSEVTVPGTRILQGARAEDADQPGPFSTVEYQVLPGP 186

  Fly   203 YGQVVYYLQELDGDNDVFSIATHQGKGILRLQKELDYERKSLYQLRVLAIDRANQGPINTGTAAI 267
            |.:.|.:|..|:              |.|.|:|.||||:...:.:::.|.|:..  |.......:
  Fly   187 YSEYVQFLNPLE--------------GTLVLKKALDYEQLQNFTVKLRAQDQGT--PPRHSDTLL 235

  Fly   268 LVKVKDLEDQPPEFVEVQAVARIAEDAPVGTKVLR---VRAIDGDRGINNPIAYSL-EAND--LF 326
            .|.:.|.:||.|:|......|.|..|...|...:|   ::|:|.|.||..||.|:: ::.|  .|
  Fly   236 RVVITDADDQNPKFQRESYSAEIPADGRPGELRMRPEPLKAVDQDEGICAPIQYTIVQSQDAKYF 300

  Fly   327 DINPHTGIVHTLTKLDREEQSDQVNGAHILRISATELSKSNTQMAPTTVRTEVTVIVSDVNDEIP 391
            .|:||.|.:..||.:.   .:|..|||.:: :.||::...: :.|.|||
  Fly   301 RIHPHNGAISLLTPIG---YADVANGATLV-VKATQIDNPD-RYALTTV---------------- 344

  Fly   392 TFGETVYRCEVNENAQTNTPLNFIDEEVQNVVFDHDEGNNGTFRLFLDPPNDLFEIVPELAVNEA 456
                           |...|.:..|                               :..||..:.
  Fly   345 ---------------QLTRPGSHSD-------------------------------LSTLAFVQK 363

  Fly   457 NFMLRVKNSKSLDFEQFTEVNFTIFAREVDEPSRWSSAHVQIFIRDQ-NDNFPEFSQTIYNASVL 520
            .|::|::..        |.|...|.|...::|.:    |::..|.|. |..|  ||.
  Fly   364 RFVMRIRED--------TAVGNRILALPTNKPGK----HLKYVIPDPVNSQF--FSV-------- 406

  Fly   521 ENSEQDTIITHVQAVDVDSGDYGTMGIRYTNLRGGIAHLLNLNPITGVITIKQAGGTAFDREIIS 585
                                             |.:..|:...|:              |.|.::
  Fly   407 ---------------------------------GSLGELVLAKPL--------------DYEKMT 424

  Fly   586 RHYLTVEAIDNAGQGNRNTAQIIVDILDVNDNAPTFPQRQYETKL----LENQAE-FETPL--QL 643
            :|...|.|.|  |..| :||::.::::||||..|.|.:..||..:    |:::|: ||..|  ::
  Fly   425 KHEFQVLATD--GMTN-STAELTLEVIDVNDWEPRFRETHYEFMVPKSSLQSRADSFEGVLIGKV 486

  Fly   644 EARDADLNGTENSQVTYEIVEGLYRSNFTIDPQSGL-LRPVHSFDFEELVDGSSRRSDPYTGGSF 707
            ||.|.|.|  :..:::   :.|.:...|.||....: :||      |:|             .|.
  Fly   487 EAADGDRN--DKLELS---LRGQHAGLFEIDSTGNIYMRP------EQL-------------QSL 527

  Fly   708 SIREIDLLVRARDSGIPMLSTVVPVLIYVQDV-------NDN--------------------API 745
            :...:.|:..|.|:|:|..||.|||.:.::.:       |.|                    ..|
  Fly   528 NESTVHLIAIATDTGVPPRSTSVPVSVTMEGLTLARSGWNSNMLGMFGMIMGLFLMIIVALSCYI 592

  Fly   746 FQQSFYAKTVPEDLPGGSSVLQVTAIDRDGSAPNNVVVYRIQTGAGD---KFIINSETGVISVAH 807
            .:.....|:....|..|.:.:...|.....||  |:|.:....|.|:   ..:.:....|:.:.|
  Fly   593 VRSKKQGKSASSGLGLGRNRVHSQAHSSVSSA--NLVTHEKLAGNGNGNGASVTSGGVSVLHMKH 655

  Fly   808 GANL 811
            |.|:
  Fly   656 GGNI 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad88C	NP_731930.3	Cadherin_repeat	76..168	CDD:206637	24/104 (23%)
		Cadherin_repeat	179..276	CDD:206637	25/111 (23%)
		Cadherin_repeat	287..388	CDD:206637	31/106 (29%)
		Cadherin_repeat	397..506	CDD:206637	16/109 (15%)
		Cadherin_repeat	514..617	CDD:206637	16/102 (16%)
		Cadherin_repeat	625..742	CDD:206637	32/131 (24%)
		Cadherin_repeat	751..853	CDD:206637	14/64 (22%)
		Cadherin_repeat	865..976	CDD:206637
		Cadherin_repeat	985..1080	CDD:206637
		Cadherin_repeat	1090..1191	CDD:206637
		CA	1221..1302	CDD:214520
		Cadherin_repeat	1312..1409	CDD:206637
		Cadherin_repeat	1418..>1502	CDD:206637
		Cadherin_repeat	1617..1710	CDD:206637
Cad96Cb	NP_001287524.1	Cadherin_repeat	46..137	CDD:206637	24/103 (23%)
		Cadherin_repeat	145..244	CDD:206637	25/114 (22%)
		Cadherin_repeat	253..347	CDD:206637	32/129 (25%)
		Cadherin_repeat	365..452	CDD:206637	29/158 (18%)
		Cadherin_repeat	461..555	CDD:206637	31/117 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24028
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100