DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad88C and Fat4

DIOPT Version :9

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:NP_899044.3 Gene:Fat4 / 329628 MGIID:3045256 Length:4981 Species:Mus musculus


Alignment Length:2059 Identity:537/2059 - (26%)
Similarity:858/2059 - (41%) Gaps:441/2059 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 NESQPPANGNGIDSMDYKKVRLKGQRRRSFSSYISSI--------SIQVIILTTLISLVASNRPP 59
            |:::|..|     |.:|.....:.||..||...:|::        .::.....|         .|
Mouse  1094 NDNRPLFN-----STNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYAFEVT---------QP 1144

  Fly    60 RF---AIDGQSEIVLRL-KESPETKVGTLI--YTLKGYD--------------------PDNDP- 97
            .|   |:.|:.....:. :||...:.||.:  :|:...|                    .||.| 
Mouse  1145 NFELHAVTGEITSTHKFDRESLMRRRGTAVFSFTVTAMDRGLPQPLKDQATVHVYMKDINDNAPK 1209

  Fly    98 -------LTFGKRNSHDSEIIRIENTG---------------GNEAKIF----------LAKELD 130
                   .|..:..::.::::|:..:.               |||.:.|          |..:||
Mouse  1210 FLKDFYQATVSETATNLTQVLRVSASDVDEGSNGLIHYSILKGNEERQFAIDSFSGQVTLVGKLD 1274

  Fly   131 RELQDEYAIVLTLTDSHYSDHNYVTQSFLLLVEDINDNVPTFLPYQNAIEIPEGSAPG-VVSTLE 194
            .|....|::::...||.....| .|.:..:.:.|.|||.|:|......:::.|....| :||::.
Mouse  1275 YEATSAYSLLIQAVDSGAIPLN-STCTLSIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVT 1338

  Fly   195 ATDADEGAYGQVVYYLQELDGDND--VFSIATHQGKGILRLQKELDYERKSLYQLRVLAIDRANQ 257
            |||:|.|....:.|   .:.|.|:  .|||:.:.|.  :.|.|:||:|.:|||:|.:.|.|:.. 
Mouse  1339 ATDSDSGVNADLHY---TITGSNNHGTFSISPNTGS--IFLAKKLDFETQSLYKLNITAKDQGR- 1397

  Fly   258 GPINTGTAAILVKVKDLEDQPPEFVEVQAVARIAEDAPVGTKVLRVRAIDGDRGINNPIAYS--- 319
             |..:.|.:::::|:|..|.||.|........|.|:.|:||.|:.|.|.|.|..||..::|:   
Mouse  1398 -PPRSSTMSVVIQVRDFNDNPPSFPPGDIFKSIVENIPLGTSVISVTAHDPDADINGQLSYAIIQ 1461

  Fly   320 -LEANDLFDINPHTGIVHTLTKLDREEQSDQVNGAHILRISATELSKSNTQMAPTTVR----TEV 379
             :...:.|.|:...|.::|..::|||       .|::..::.    |:|.|..|...|    ..|
Mouse  1462 QMPRGNHFSIDEVKGTIYTSAEIDRE-------FANLFELTV----KANDQAVPIETRRYALKNV 1515

  Fly   380 TVIVSDVNDEIPTFGETVYRCEVNENAQTNTPLNFIDEEVQNVV-FDHDEGNNGTFRL-FLDPPN 442
            |::|:|:||.:|.|        :::||....|...|...:..:: .|.|||.||.... .|:...
Mouse  1516 TILVTDLNDNVPMF--------ISQNALAADPSAMIGSVLTTIMAADPDEGANGEVEYEILNGDT 1572

  Fly   443 DLFEIVPELAVNEANFMLRVKNSKSLDFEQFTEVNFTIFAREVDEPSRWSSAHVQIFIRDQNDNF 507
            |.|      .|:..:..|||  :.:|...|.. .|..:.|.::....|.|:..:.:.:  |..:.
Mouse  1573 DTF------TVDRYSGDLRV--ASALVPSQLI-YNLIVSATDLGPERRKSTTELTVIL--QGLDG 1626

  Fly   508 PEFSQTIYNASVLENSEQDTIITHVQAVDVDSG-------DYGTMGIRYTNLRGGIAHLLNLNPI 565
            |.|:||.| .::|:  |.:.|.|:|.:::..|.       :|..:.:|.....  :..|..:...
Mouse  1627 PVFTQTKY-ITILK--EGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKT--VGRLFTIGRQ 1686

  Fly   566 TGVITIKQAGGTAFDREIISRHYLT-VEAIDNAGQGNR-NTAQIIVDILDVNDNAPTFPQRQYET 628
            ||||..    ....|||..:..||. |.||:.:....| ..|::.:.:.|:|||.|.||....:.
Mouse  1687 TGVIQT----AAILDREQGACLYLVDVYAIEKSSAFPRTQRAEVEITLQDINDNPPVFPTDTLDL 1747

  Fly   629 KLLENQAEFETPLQLEARDADLNGTENSQVTYEIVEGLYRSNFTIDPQSGLLRPVHSFDFEELVD 693
            .:.||..:....:||.|.|||...  |:.|||.::.|. ..:|.|||:||           :|: 
Mouse  1748 TVEENIGDGSKIMQLTAMDADEGA--NALVTYALISGA-DDSFRIDPESG-----------DLI- 1797

  Fly   694 GSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFYAKTVPED 758
             :::|.|......:|     |||||.|.   :.|:.:.:.|.:.||||:.|.|.:..|:..:|||
Mouse  1798 -ATKRLDREHRSKYS-----LLVRADDG---LQSSDMRINITISDVNDHTPRFSRPVYSFDIPED 1853

  Fly   759 LPGGSSVLQVTAIDRDGSAPNNVVVYRIQTGAGD-KFIINSETGVISVAHGANLDPDLTESKRSL 822
            ...||.|..:.|.| |.|..|..:.|.::...|| .|.:|..|||.      ||...|....:..
Mouse  1854 TTPGSLVAAILATD-DDSGVNGEISYVVEEDDGDGVFFLNLVTGVF------NLTRALDYETQQY 1911

  Fly   823 YTLSVIALDGGLGNSQLMTTCTVNISIQDVNNKPPVLK-EMPALQILENTPVGTLVYRIQATDLD 886
            |.|:|.|.||| |.|   ||.....:|.|||:.|||.. ...:..::||.|:|:.|.....||.|
Mouse  1912 YILTVRAEDGG-GQS---TTIRAYFNILDVNDNPPVFSMSSYSTSLMENLPLGSTVLVFNVTDAD 1972

  Fly   887 H--KAILRYKLNPEHCEGRTEEGALVKSSEYDFLGAFEVDSIEGTLKVVKLLDRERVEHIKLAIT 949
            .  .:.|.|.:                 :..|.||.|.||. .|.||.:|.||||......|.|.
Mouse  1973 DGVNSQLSYSI-----------------ASGDSLGQFAVDK-HGVLKTLKALDRESQSFYNLVIQ 2019

  Fly   950 VEDL-AAAKGRQIAEGFLSIQVLDENDNNPKFRLPFYRQSITENSINGAMIVNVLASDVDK--NR 1011
            |.|| .....|..:...:||.:||.|||.|.|..|.... |.||:....::....|:|.|.  |.
Mouse  2020 VHDLPQPPTSRFTSTAQVSIILLDVNDNPPMFLSPKLTY-IPENTPIDTVVFKAQATDPDSGPNS 2083

  Fly  1012 TITYALEGNPTYR--SLMHLDPQTGEIVVASKIDHEQHQWLNFSVRATDSGIPARSSLVDVYITV 1074
            .|.|.|. ||:..  |:..:|   ||:.:..::|.|:....:.:|.|||.|.|..||..:|.:.|
Mouse  2084 YIEYTLL-NPSGNKFSIGTID---GEVHLTGELDREEVSNYSLTVVATDKGQPPLSSSTEVVVMV 2144

  Fly  1075 LDENDNNPYFVGGSKNYTISENAAPGTRVATLQAGDADSGDFGKITFLMDRISSQGKFTIDADTG 1139
            ||.|||||.|........|.||...||.:..:.|.|.|.|..|::.:.:...::..:|.||:.||
Mouse  2145 LDINDNNPVFAQAMYRVQIKENILTGTDIIQVSAADNDEGTNGQVRYGIVGGNTHQEFRIDSVTG 2209

  Fly  1140 VLTVADRLDRESKDSYNLVIEAWDNYQFGFLAGES-RNAFKQVFISILDENDNPPEVDL-PMSCV 1202
            .:|||..||||:..:|.|.::|.|.       |.| |.....|.|::||.||..|..:| |.|..
Mouse  2210 AITVAKSLDRETTPAYTLTVQATDR-------GSSPRTDSCTVAITLLDMNDFVPVFELSPYSVN 2267

  Fly  1203 LITEYHELHERVASIVGKDADDPTTPNGRLDFAITRGNKDGMFELRQIDAWNAQIFASKSL-RNR 1266
            :......|...:..:|.:  ||...||.:|.:.:..||:|..|.|..    :.::..::|| |..
Mouse  2268 VPENLGTLPRAILQVVAR--DDDQGPNSQLSYVLLGGNEDNAFVLTA----SGELRVTQSLDREA 2326

  Fly  1267 YGNYSLTITTRDMGLPANIVHNTLDICVSDFNDHAPVFVRPLHNTTVRIPENATVGTLILQAYAS 1331
            ..::.|.:|..|.|.||.....|::|.|.|.||:.|.|...::.|:  |.|:|..||.:|...||
Mouse  2327 RDHFVLVVTAADAGSPALTGTGTINIIVDDINDNVPTFANNMYLTS--IAEDARTGTDVLLVNAS 2389

  Fly  1332 DGDMGQNALVRYRLKPDPLGSYKMFEVDGSTGELFLKEQLNREKQKIHEIRIEAYDQGLPTSLSS 1396
            |.|...||::.|.:    :|....|.::.|||::.....|:||.:..:.:.:.|.|.|.|.||||
Mouse  2390 DADAAANAVISYSI----IGGNSQFTINPSTGQIITSALLDRETKDNYTLVVVASDAGSPESLSS 2450

  Fly  1397 DLDLTIYVRNVNDYEPQFM----VNEI-------------------------------------- 1419
            ...:.:.:.:|||..|:|.    |..|                                      
Mouse  2451 STSVLVTITDVNDNPPRFQHHPYVTHIPSPTPPGSFVFAVTVTDADIGSNSELHYSLSGRNSEKF 2515

  Fly  1420 -------------------SVNFTEH-SDPGS--------------ERIKLPDTIDKDQLELDDP 1450
                               .|.|:.| .|.||              .:...|....|:|..: .|
Mouse  2516 HIDPLRGAIMAAGPLSGASEVTFSVHVKDGGSFPKTDSTTVTVRFANKADFPKVRAKEQTFM-FP 2579

  Fly  1451 NDTP---------------SQVCYFIVNGNEAGYFRLDPETHILTVDRELDREVIANFTLYVRAT 1500
            .:.|               ..:.|:|.:||....|::||.|..:::.:.||.|.|..:.:::.|.
Mouse  2580 ENQPVGTLVTTITGSSLRGETLSYYIASGNLGDTFQIDPLTGQVSISQPLDFEKIQKYVVWIEAR 2644

  Fly  1501 ENCRNDSISGG-------EKRRRMGIEINNRLGGIVHNQQFGYDRFKHS-------RQLR--STE 1549
            :        ||       ||.....::||:      :...|..|.|...       |::.  |..
Mouse  2645 D--------GGFPPFSSYEKLDITVLDIND------NAPTFEEDPFVSEILENLSPRKILTVSAT 2695

  Fly  1550 SNEYGPEDAELLSYEAYDSSQED------PTGGLAT---------THPEL-----------DSTV 1588
            ..:.||...  |.||..:.:||.      .||.:.:         :|.||           .||.
Mouse  2696 DKDSGPNGQ--LDYEIVNGNQESSFTINHATGEIRSIRPLDREKISHYELTVKSSDKGSPSQSTS 2758

  Fly  1589 IKVKVRVLDINDNPPRFRSKIFTGGITTNADFGLKFMRVEATDADEGDNGRIGYYQVGEIRQTLS 1653
            :||.:.:||.|||.||| |:||:..::.|:..|....||..:|.|.|.|. |..|.:.:      
Mouse  2759 VKVIISILDENDNAPRF-SQIFSAYVSENSPLGYTVTRVTTSDEDIGINA-ISRYSIVD------ 2815

  Fly  1654 EGLENVRKAPFLLDQETGEVQLNFDPQKGMKGYFDFVVLANDTSGMKDVAHVFIYLLR-EDQKVR 1717
                  ...||.::..||::.::....:.....:...|.|:| ||......|.|::.. .|...|
Mouse  2816 ------TSLPFTINPNTGDIVISRPLNREDTDRYRIRVSAHD-SGWTVSTDVTIFVTDINDNTPR 2873

  Fly  1718 F---------------------VFRLQPDE---------LRSRVDSFRDTLSNITESIVNIDEIK 1752
            |                     |....|||         ::|:.:.||  ::..|..|.|...:|
Mouse  2874 FSRPSYYLDCPELPELGSRVTQVSATDPDEGSNGQVFYFIKSQSEYFR--INATTGEIFNKQVLK 2936

  Fly  1753 VHENKDG--SVDKTKTDLYMHLVEREDNSIY-EVSEVLKLIDSH 1793
             ::|..|  :|:..:....:...:|.:.|:. |.:..:..:||:
Mouse  2937 -YQNVSGFSNVNINRHSFIVTASDRGNPSLLSETTVTINTVDSN 2979

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637 25/146 (17%)
Cadherin_repeat 179..276 CDD:206637 31/99 (31%)
Cadherin_repeat 287..388 CDD:206637 30/108 (28%)
Cadherin_repeat 397..506 CDD:206637 24/110 (22%)
Cadherin_repeat 514..617 CDD:206637 26/111 (23%)
Cadherin_repeat 625..742 CDD:206637 34/116 (29%)
Cadherin_repeat 751..853 CDD:206637 36/102 (35%)
Cadherin_repeat 865..976 CDD:206637 35/113 (31%)
Cadherin_repeat 985..1080 CDD:206637 31/98 (32%)
Cadherin_repeat 1090..1191 CDD:206637 34/101 (34%)
CA 1221..1302 CDD:214520 25/81 (31%)
Cadherin_repeat 1312..1409 CDD:206637 30/96 (31%)
Cadherin_repeat 1418..>1502 CDD:206637 25/170 (15%)
Cadherin_repeat 1617..1710 CDD:206637 21/92 (23%)
Fat4NP_899044.3 Cadherin_repeat 48..131 CDD:206637
Cadherin_repeat 139..246 CDD:206637
Cadherin_repeat 254..349 CDD:206637
Cadherin_repeat 364..471 CDD:206637
Cadherin_repeat 479..577 CDD:206637
Cadherin_repeat 588..685 CDD:206637
Cadherin_repeat 693..789 CDD:206637
Cadherin_repeat 798..889 CDD:206637
Cadherin_repeat 904..992 CDD:206637
Cadherin_repeat 1000..1096 CDD:206637 1/1 (100%)
Cadherin_repeat 1105..1206 CDD:206637 17/109 (16%)
Cadherin_repeat 1215..1311 CDD:206637 17/96 (18%)
Cadherin_repeat 1321..1416 CDD:206637 31/101 (31%)
Cadherin_repeat 1428..1525 CDD:206637 31/107 (29%)
Cadherin_repeat 1540..1622 CDD:206637 20/92 (22%)
Cadherin_repeat 1634..1736 CDD:206637 26/110 (24%)
Cadherin_repeat 1747..1837 CDD:206637 34/113 (30%)
Cadherin_repeat 1845..1940 CDD:206637 38/105 (36%)
Cadherin_repeat 1948..2047 CDD:206637 35/116 (30%)
Cadherin_repeat 2057..2150 CDD:206637 31/97 (32%)
Cadherin_repeat 2159..2254 CDD:206637 33/101 (33%)
Cadherin_repeat 2263..2360 CDD:206637 28/102 (27%)
Cadherin_repeat 2369..2464 CDD:206637 32/100 (32%)
Cadherin_repeat 2472..2559 CDD:206637 8/86 (9%)
Cadherin_repeat 2573..2667 CDD:206637 22/108 (20%)
Cadherin_repeat 2675..2771 CDD:206637 22/97 (23%)
Cadherin_repeat 2778..2870 CDD:206637 23/105 (22%)
Cadherin_repeat 2878..2981 CDD:206637 19/105 (18%)
Cadherin_repeat 2990..3085 CDD:206637
Cadherin_repeat 3095..3192 CDD:206637
Cadherin_repeat 3200..3295 CDD:206637
Cadherin_repeat 3305..3402 CDD:206637
Cadherin_repeat 3410..3508 CDD:206637
Cadherin_repeat 3516..3612 CDD:206637
EGF_CA 3804..3862 CDD:238011
EGF_CA 3864..3900 CDD:238011
EGF_CA 3902..3938 CDD:238011
EGF_CA 3941..3976 CDD:238011
LamG 3979..4142 CDD:238058
EGF_CA 4168..4200 CDD:238011
Laminin_G_2 4252..4372 CDD:366983
EGF_CA 4430..4464 CDD:238011
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4535..4585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4677..4713
Necessary and sufficient for interaction with MPDZ. /evidence=ECO:0000269|PubMed:19506035 4708..4797
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4753..4773
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4796..4911
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4957..4981
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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