DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad88C and Pcdh9

DIOPT Version :9

Sequence 1:	NP_731930.3	Gene:	Cad88C / 41774	FlyBaseID:	FBgn0038247	Length:	1981	Species:	Drosophila melanogaster
Sequence 2:	NP_001178617.1	Gene:	Pcdh9 / 306091	RGDID:	1306348	Length:	1237	Species:	Rattus norvegicus

Alignment Length:	1158	Identity:	307/1158 - (26%)
Similarity:	458/1158 - (39%)	Gaps:	290/1158 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LIYTLKGYDPDNDPLTFGKRN---SH--------------------DSEIIRIENTGGNEAKIF- 124
            ||||::...|:|.|:....::   ||                    |:.::::.::.|   :||
  Rat    26 LIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTG---EIFT 87

  Fly   125 LAKELDRELQDEYAIVLTLTDSHYSDHN---------YVTQSFL------LLVEDINDNVPTF-L 173
            .:..:|||        .....:.|::.|         .:...|.      ::|:|.|||.|.| .
  Rat    88 TSNRIDRE--------KLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPS 144

  Fly   174 PYQNAIEIPEGSAPGVVSTL--------EATDADEGAYGQVVYYLQELDGDNDVFS---IATHQG 227
            |..| |.|||       :||        .|||.|.|..| |.:|  ||.....||.   :.|.:|
  Rat   145 PVIN-ISIPE-------NTLINSRFPIPSATDPDTGFNG-VQHY--ELLNGQSVFGLDIVETPEG 198

  Fly   228 K--GILRLQKELDYERKSLYQLRVLAIDRANQGPINTGTAAILVKVKDLEDQPPEFVEVQAVARI 290
            :  ..|.:|:.||.|:|..|.:::...|...  |..:.||.:.|.|.|:.|..|.|.|.|....|
  Rat   199 EKWPQLIVQQNLDREQKDTYVMKIKVEDGGT--PQKSSTAILQVTVSDVNDNRPVFKEGQVEVHI 261

  Fly   291 AEDAPVGTKVLRVRAIDGDRGINNPIAYSLEA------NDLFDINPHTGIVHTLTKLDREEQSDQ 349
            .|:|||||.|:::.|.|.|.|.|..|.|...|      ..||.:|..||::.....|||||
  Rat   262 PENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREE---- 322

  Fly   350 VNGAHILRISATELSKSNTQMAPTTVRTEVTVIVSDVNDEIPT---------FGETVYRCEVNEN 405
             ...|.:.:.|::.|.       |..|..||:.|:||||..|.         ...|||   ::|.
  Rat   323 -TAIHKVTVLASDGSS-------TPARATVTINVTDVNDNPPNIDLRYIISPINGTVY---LSEK 376

  Fly   406 AQTNTPLNFIDEEVQNVVFDHDEGNNGTFRLFLDPPNDLFEIVPEL-AVNEANFMLRVKNSKSLD 469
            ...||.:..|      .|.|.|...||....|::.     |:...| ||.:..::|  :.|..||
  Rat   377 DPVNTKIALI------TVSDKDTDVNGKVICFIER-----EVPFHLKAVYDNQYLL--ETSSLLD 428

  Fly   470 FEQFTEVNFTIFAREVDEPSRWSSAHVQIFIRDQNDNFPEFSQTIYNASVLENSEQDTIITHVQA 534
            :|...|.:|.|.|.:..:||...:|.|::.:.|:|||.|.|:|.:...||.||:.:...:|.:.|
  Rat   429 YEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISA 493

  Fly   535 VDVDSGDYGTMGIRYTNLRGGIAHLLNLNPITGVITIKQAGGTAFDREIISRHYLTVEAIDNAGQ 599
            .|.|||....:..:.    |..|...:|:..|||:|..:    .|:||...|...||.|.||...
  Rat   494 TDEDSGKNADIVYQL----GPNASFFDLDRKTGVLTASR----VFNREEQERFIFTVTARDNGTP 550

  Fly   600 GNRNTAQIIVDILDVNDNAPTFPQRQYETKLLENQAEFETPLQLEARDADLNGTENSQVTYEIVE 664
            ..::.|.:||.:||.|||:|.|....::..:.||..::.|...:...|.|..  ||..||..|:.
  Rat   551 PLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDEDAG--ENKAVTLSILN 613

  Fly   665 GLYRSNFTIDPQSGLLRPVHSFDFEELVDGSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTV 729
            .  ..||.:||.||:::...|||.|:        ...||        .|  |:|.|.|.|..|:.
  Rat   614 D--NENFVLDPYSGVIKSNVSFDREQ--------QSSYT--------FD--VKATDGGQPPRSST 658

  Fly   730 VPVLIYVQDVNDNAPIF-----QQSFYAKTVPEDLPGGSSVLQVTAIDRDGSAPNNVVVYRIQTG 789
            ..|.|.|.|||||:|:.     ..||  |.||.....||.|.:|.|:|.| :..|..:.|.|.:|
  Rat   659 AKVTINVMDVNDNSPVVISPPSNTSF--KLVPLSAIPGSVVAEVFAVDID-TGMNAELKYTIVSG 720

  Fly   790 AGDK--FIINSETGVISVAHGANLDPDLTESKRSLYTLSVIALDGGLGNSQLMTTCTVNISIQDV 852
             .:|  |.|:..||.|::           |.|.:       ..|.||..      ..||||  |:
  Rat   721 -NNKGLFRIDPVTGNITL-----------EEKPA-------PTDVGLHR------LVVNIS--DL 758

  Fly   853 NNKPPVLKEMPALQILENTPVGT------LVYRIQATDLDHKAILRYKLNPEHCEGRTEEGALVK 911
             ..|..|..:..:.:..|...|.      |:.|...|.||...              .:.|...:
  Rat   759 -GYPKALHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLDRNI--------------GDSGQPYQ 808

  Fly   912 SSEYDFLGAFEVDSIEGTLKVVKLLDRERVEHIKLAITV--------EDLAAAKGRQIAEGFLSI 968
            :.:|   ....:..:.|.:.|:          :.:.:||        ...||.:.:|.||.....
  Rat   809 NEDY---LTIMIAIVAGAMVVI----------VVIFVTVLVRCRHASRFKAAQRSKQGAEWMSPN 860

  Fly   969 QVLDENDNNPKFRLPFYRQSITENSINGAMIVNVLASDVDKNRTITYALEGNPTYRSLMHLDPQT 1033
            |   ||..|.|.:.. .|:|...:.:|   .|.:..|..|                ..:| :|..
  Rat   861 Q---ENKQNKKKKRK-KRKSPKSSLLN---FVTIEESKPD----------------DAVH-EPIN 901

  Fly  1034 GEIVVASKIDHE---QHQW-----LNFSVRATD--------SGIPARSSLVDVYITVLDENDNNP 1082
            |.|.:.::::.:   :..|     ..|...:.|        |..||.....|..::|
  Rat   902 GTISLPAELEEQSIGRFDWGPAPPTTFKPNSPDLAKHYKSASPQPAFHLKPDTPVSV-------- 958

  Fly  1083 YFVGGSKNYTISENAAPGTRVA---TLQAGDADSGDFGKITFLMDRISSQGKF 1132
                 .|::.|.|.....|.|.   ||....:.|.|.    |.....||||.|
  Rat   959 -----KKHHVIQELPLDNTFVGGCDTLSKRSSTSSDH----FSASECSSQGGF 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad88C	NP_731930.3	Cadherin_repeat	76..168	CDD:206637	22/122 (18%)
		Cadherin_repeat	179..276	CDD:206637	34/109 (31%)
		Cadherin_repeat	287..388	CDD:206637	36/106 (34%)
		Cadherin_repeat	397..506	CDD:206637	31/109 (28%)
		Cadherin_repeat	514..617	CDD:206637	32/102 (31%)
		Cadherin_repeat	625..742	CDD:206637	35/116 (30%)
		Cadherin_repeat	751..853	CDD:206637	30/103 (29%)
		Cadherin_repeat	865..976	CDD:206637	21/124 (17%)
		Cadherin_repeat	985..1080	CDD:206637	18/110 (16%)
		Cadherin_repeat	1090..1191	CDD:206637	14/46 (30%)
		CA	1221..1302	CDD:214520
		Cadherin_repeat	1312..1409	CDD:206637
		Cadherin_repeat	1418..>1502	CDD:206637
		Cadherin_repeat	1617..1710	CDD:206637
Pcdh9	NP_001178617.1	Cadherin_repeat	29..138	CDD:206637	19/119 (16%)
		Cadherin_repeat	146..248	CDD:206637	35/114 (31%)
		Cadherin_repeat	258..354	CDD:206637	37/107 (35%)
		Cadherin_repeat	370..465	CDD:206637	32/110 (29%)
		Cadherin_repeat	473..568	CDD:206637	32/102 (31%)
		Cadherin_repeat	576..671	CDD:206637	35/116 (30%)
		Cadherin_repeat	687..776	CDD:206637	31/117 (26%)
		Protocadherin	777..1000	CDD:400603	52/290 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000