DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad88C and Pcdh20

DIOPT Version :9

Sequence 1:	NP_731930.3	Gene:	Cad88C / 41774	FlyBaseID:	FBgn0038247	Length:	1981	Species:	Drosophila melanogaster
Sequence 2:	NP_001100750.1	Gene:	Pcdh20 / 306081	RGDID:	1306297	Length:	952	Species:	Rattus norvegicus

Alignment Length:	871	Identity:	215/871 - (24%)
Similarity:	342/871 - (39%)	Gaps:	250/871 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   606 QIIVDILDVNDNAPTFPQRQYETKLLENQAEFETPLQLE--ARDAD--LNGTENSQVTYEIVEGL 666
            ::.:.|.|:|||||.||..:....:.|| :...|.|.:|  |.|.|  :||.:    ||.:::
  Rat   195 KVKIAIRDINDNAPQFPISEISVWVPEN-SPVNTRLAIEHPAVDPDVGINGVQ----TYRLLD-- 252

  Fly   667 YRSNFTID---PQSGLLRPVHSFDFEELVDGSSRR--SDPYTGGSFSIREIDLLVRARDSGIPML 726
            |...||:|   .::|...|.      .:|.|:..|  .|.|..          ::.|.|.|.|.|
  Rat   253 YHGMFTLDVEENENGERTPY------LIVMGALDRETQDQYVS----------IIIAEDGGSPPL 301

  Fly   727 STVVPVLIYVQDVNDNAPIFQQSFYAKTVPEDLPGGSSVLQVTAIDRDGSAPNNVVVY----RIQ 787
            .....:.|.:.|:|||.|:|..|....||..:...|:.|..|.|:||| ...|..:.|    ::.
  Rat   302 LGSATLTIGISDINDNCPLFIDSQINVTVYGNATVGTPVTTVQAVDRD-LGTNAQITYSYSQKVP 365

  Fly   788 TGAGDKFIINSETGVISVAH--GANLDPDLTESKRSLYTLSVIALDGGLGNSQLMTTCTVNISIQ 850
            ..:.:.|.::..|||:.::.  |.|:          |.|..:..|..|.|  .:....|..:||.
  Rat   366 QESKELFHLDEVTGVVKLSSKIGGNV----------LQTHKLTILANGPG--CIPAVITALVSII 418

  Fly   851 DVNNKPP------VLKEMPALQILE-----NTPVGTLVYRIQATDLDHKAILRYKLNPEHCEGRT 904
            .|..:||      :..||..:..|:     |||:.....|    |.:.|    ||:|. :.||
  Rat   419 KVVFRPPEIVPRYIANEMDGVVYLKELEPVNTPIAFFTIR----DPEGK----YKINC-YLEG-- 472

  Fly   905 EEGALVKSSEYDFLGAFEVDSIEGTLKVVKLLDRERVEHIKLAITVEDLAAAKGRQIAEGF---- 965
             ||..       .|..::..:.|..|:..|.:|.|.....::|:...:         :|||
  Rat   473 -EGPF-------RLAPYKPYNNEYLLETTKPMDYELQPFYEIAVVAWN---------SEGFHDKR 520

  Fly   966 -LSIQVLDENDNNPKFRLPFYRQSITENSINGAMIVNVLASDVDKNR--TITYALEGNPTYRSLM 1027
             :.:|:||:|||.|.|..|....:|.||:...|.:..:.|:|.|...  .::|.|  .|...|..
  Rat   521 IIKVQLLDDNDNAPVFLQPLIELTIEENNAPNAFLTKLYATDADSGEMGRVSYFL--GPDAPSYF 583

  Fly  1028 HLDPQTGEIVVASKIDHEQHQWLNFSVRATDSGIPARSSLVDVYITVLDENDNNPYFVGGSKNYT 1092
            .||..||.:.|::::|.|:.:...::|||.|.|.|.|.|:..|.:||||:|||:|.|:....::.
  Rat   584 SLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFF 648

  Fly  1093 ISENAAPGTRVATLQAGDADSGDFGKITFLMDRISSQGKFTIDADTGVLTVADRLDRESKDSYNL 1157
            :.||......:..:...|||:|..|.:.  :..::....|.||...|:|.....||||.:.||.|
  Rat   649 VPENFPGYGEIGVISVTDADAGRNGWVA--LSVMNQSDIFVIDTGKGMLRAKVSLDREQQSSYTL 711

  Fly  1158 VIEAWDNYQFGFLAGE-SRNAFKQVFISILDENDNPPEVDLP---MSCVLITEYHELHERVASIV 1218
            .:||.|       .|| :.::..::.|.:||.|||||.|..|   ||.:|:.
  Rat   712 WVEAVD-------GGEPALSSTTKITILLLDINDNPPLVLFPQSNMSYLLVL------------- 756

  Fly  1219 GKDADDPTTPNGRLDFAITRGNKDGMFELRQIDAWNAQIFASKSLRNRYGNYSLTITTRDMGLPA 1283
                  |:|                                                     ||
  Rat   757 ------PST-----------------------------------------------------LP- 761

  Fly  1284 NIVHNTLDICVSDFNDHAPVFVRPLHNTTVRIPENATVGTLILQAYASDGDMGQNALVRY----R 1344
                                                  |:.:.:.||.|.|.|.||::.|    |
  Rat   762 --------------------------------------GSPVTEVYAVDKDTGMNAVIAYSIIGR 788

  Fly  1345 LKPDPLGSYKMFEVDGSTGELFLKEQLNREKQKIHEIRIEAYDQGLPTSLSSDLDLTIYVR---- 1405
            ..|.|    :.|.:|..||.:.|:|.|.:....:|.:.::..|.|.|..|.|.:.:.::|.
  Rat   789 RGPRP----ESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVS 849

  Fly  1406 ---------------NVNDYEPQFMV 1416
                           |:.:.|||..:
  Rat   850 NESYIESLLRKEPEINIEEKEPQISI 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad88C	NP_731930.3	Cadherin_repeat	76..168	CDD:206637
		Cadherin_repeat	179..276	CDD:206637
		Cadherin_repeat	287..388	CDD:206637
		Cadherin_repeat	397..506	CDD:206637
		Cadherin_repeat	514..617	CDD:206637	3/10 (30%)
		Cadherin_repeat	625..742	CDD:206637	31/125 (25%)
		Cadherin_repeat	751..853	CDD:206637	25/107 (23%)
		Cadherin_repeat	865..976	CDD:206637	28/120 (23%)
		Cadherin_repeat	985..1080	CDD:206637	32/96 (33%)
		Cadherin_repeat	1090..1191	CDD:206637	28/101 (28%)
		CA	1221..1302	CDD:214520	4/80 (5%)
		Cadherin_repeat	1312..1409	CDD:206637	27/119 (23%)
		Cadherin_repeat	1418..>1502	CDD:206637
		Cadherin_repeat	1617..1710	CDD:206637
Pcdh20	NP_001100750.1	E_set	70..>153	CDD:298831
		Cadherin_repeat	214..317	CDD:206637	31/125 (25%)
		Cadherin_repeat	325..417	CDD:206637	23/104 (22%)
		E_set	439..>510	CDD:298831	21/89 (24%)
		E_set	<490..534	CDD:298831	14/52 (27%)
		Cadherin_repeat	541..636	CDD:206637	32/96 (33%)
		Cadherin_repeat	645..739	CDD:206637	28/102 (27%)
		Cadherin_repeat	755..846	CDD:206637	30/205 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000