DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad88C and Cdhr2

DIOPT Version :9

Sequence 1:	NP_731930.3	Gene:	Cad88C / 41774	FlyBaseID:	FBgn0038247	Length:	1981	Species:	Drosophila melanogaster
Sequence 2:	XP_214434.4	Gene:	Cdhr2 / 291002	RGDID:	1560576	Length:	1310	Species:	Rattus norvegicus

Alignment Length:	1538	Identity:	400/1538 - (26%)
Similarity:	632/1538 - (41%)	Gaps:	369/1538 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VIILTTLISLVASNRPPRFAIDGQSEIVLRLKESPETKVGTLIYTLKGYDPDNDPLTFGKRNSHD 107
            |::.|.::|:.|::.|   ..:....:||..::.|   ||.:::.|...|||.|.||:|....|.
  Rat     9 VLLPTFMVSVTANSLP---VFESNMTLVLLPEDLP---VGAVVFWLVATDPDGDQLTYGISGLHA 67

  Fly   108 SEIIRIENTGGNEAKIFLAKELDRELQDEYAIVLTLTDSHYSDHNYVTQSFLLLVEDINDNVPTF 172
            :......|||    ::.|...||.|....:.|.:::.|.|   :..||:...::|||.|||.|.|
  Rat    68 NYFSVTSNTG----EVKLVSSLDFETLPSFRITISVNDGH---NVQVTKEMQVIVEDRNDNAPVF 125

  Fly   173 L--PYQNAIE--IPEGSAPGVVSTLEATDADEGAYGQVVYYLQEL----DGDNDVFSIATHQGKG 229
            |  .:..:|:  :|.||   ||.::.|.|.|.|:.|.|.|:::::    |...|:|.|..:   |
  Rat   126 LNTEFSTSIKETLPVGS---VVFSVLAEDKDTGSSGLVEYFIEKVIPSTDNSKDLFRILVN---G 184

  Fly   230 ILRLQKELDYERKS-LYQLRVLAIDRANQGPINTGTAA-------ILVKVKDLEDQPPEFVEVQA 286
            .:.|...|.|..|| .|||.:.|.|  :.|.:|.....       :.:.|.|..|..|:||....
  Rat   185 SIVLNDTLSYNNKSAFYQLELKACD--SGGLLNNTLVTQCSQPVFVSISVIDEPDLDPQFVREFY 247

  Fly   287 VARIAEDAPVGTKVLRVRAIDGDRGINNPIAYSLEAN---DLFDINPHTGIVHTLTKLDREE--- 345
            .|.::|||.:||.||.|.|:|.|:|:|..:.|::..:   ..|.|. ..|::.....||||:
  Rat   248 SASVSEDATLGTSVLAVEAVDSDKGVNYNVTYNITNSTRPGWFCIE-KDGVITVCGPLDREQLLL 311

  Fly   346 QSDQVNGAHILRISATELSKSNTQMAPTTVRTEVTVIVSDVNDEIPTFGETVYRCEVN------E 404
            .:::|.    ::::||| .|.|.......|.|.||:.|:||||..|.|    |.|.:.      :
  Rat   312 DNEEVQ----IQVTATE-EKPNIYQQEAKVSTWVTIKVTDVNDHKPEF----YNCSLQNCTFSPQ 367

  Fly   405 NAQTNTPLNFIDEE---------VQNVVFDHDEGNNGTFRLFLDPPN-DLFEIVPELAVNEANFM 459
            .||.|. ..::||.         :..|.:|.|:|.||||.|.|:..: :.|.:.||.|....:..
  Rat   368 EAQDNF-TGYVDEHASARISIDGLTMVAYDPDQGANGTFLLSLNGTDAEAFNVSPERAAVSVSVQ 431

  Fly   460 LRVKNSKSLDFEQFTEVNFTIFAREVDEPSRWSSAHVQIFIRDQNDNFPEFSQTIYNASVLENSE 524
            :.||||:.:|:|:.||:...:.|.: .....:|.|.|.|.:|:.||:.|.||:::|..:|.|||.
  Rat   432 VVVKNSEMVDYEKKTEMQVQVVATD-SVSGNYSVATVTIHLRNINDHRPVFSKSLYELTVPENSP 495

  Fly   525 QDTIIT-HVQAVDVDSGDYGTMGIRYTNLRGGIAHLLNLNPITGVITIKQAGGTAFDREIISRHY 588
            ...::| .::|.|:|..::|.  |.|:.|.|....|..:.|.:|.:|:|  .||..|||..:.:|
  Rat   496 TGFLVTDSIEATDLDGDEWGP--ITYSLLPGAGEDLFEVEPKSGNVTVK--NGTLLDREKQAMYY 556

  Fly   589 LTVEAIDNAGQGNRNTAQII-VDILDVNDNAPTFPQRQYETKLLENQAEFETPLQLEARDADLNG 652
            ||::|.|.   ||::|..:: :.:||||||.|.. :..|...:.|...:....:|  |.|.|..|
  Rat   557 LTMQATDG---GNQSTTTMLQITLLDVNDNPPVV-RGSYNIFVPEEDGDVSVTIQ--AYDDDQPG 615

  Fly   653 TENSQVTYEIVEGLYRSNFTIDPQSGLLRPVHSFDFEELVDGSSRRSDPYTGGSFSIREIDLLVR 717
            |.||::.:.::.|.|..||:|||.:||||.:...|.|.:        ||...|     .|.|.|.
  Rat   616 TNNSRLLFSLLPGSYSQNFSIDPDTGLLRNLEPLDREAI--------DPALEG-----RIVLTVH 667

  Fly   718 ARDSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFYAKTVPEDLPGGSSVLQVTAIDRDGSAPNNVV 782
            ..|.|.|.|||.|.|.|.|:|:|||.|||.||.|...|.|.:| |:.|..|.|.|.|.:|.||.:
  Rat   668 VADCGEPSLSTDVNVTITVEDINDNLPIFNQSSYEFFVMERVP-GALVGTVKAWDADQTAANNRI 731

  Fly   783 VYRIQTGAGDKFIINSETGVISVAHGANL----DPDLTESKRSLYTLSVIALDGGLGNSQLMTTC 843
            .:.:.....:.||:.|....:..|.| :|    |..|....:.|:.|:|.|.:.  |...|.:|.
  Rat   732 SFSLSGTGANNFILQSIVLALGWAEG-HLWLLPDVSLDYETQKLFNLTVSAENP--GPQGLESTA 793

  Fly   844 TVNISIQDVNNKPPVLK--EMPALQILENTPVGTLVYRIQATDLDHKAILRYKLNPEHCEGRTEE 906
            .:.:.:.|||::||.|.  .:.::.:.||......|.::.|.|:|..|:||.:|....|   |:.
  Rat   794 NITVVVVDVNDEPPTLDAVSLQSISVAENGSEHGQVAQVIAQDVDTNALLRIELVDVLC---TKA 855

  Fly   907 GALVKSSEYDFLGAFEVDSIEGTLKVVKLLDRERVEHIKLAITVEDLAAAKGRQIAEGFLSIQVL 971
            |..|.|                                                :..|:.|:..
  Rat   856 GVDVGS------------------------------------------------VCHGWFSVDT- 871

  Fly   972 DENDNNPKFRLPFYRQSITENSINGAMIVNVLASDVDKNRTITYALEGNPTYRSLMHLDPQTGEI 1036
                                   ||::.:|
  Rat   872 -----------------------NGSVYIN----------------------------------- 878

  Fly  1037 VVASKIDHEQHQWLNFSVR----ATDSGIPARSSLVDVYITVLDENDNNPYFVGGSKNYT-ISEN 1096
             .:..||:|....:...||    |||.|..|.||...:.|.:.|:|||.|||:..::.:. |.|.
  Rat   879 -QSEAIDYEVCHLVTLVVRAQDLATDLGFDAYSSNGSLLINIKDKNDNTPYFLPNNQTFVIIPEL 942

  Fly  1097 AAPGTRVATLQAGDADSGDFGKITFLM---DRISSQGK------FTIDAD------TGVLTVADR 1146
            ..|..:||::||.|.||.|.|.|.|.:   |.:...|.      |.|...      ||.:.:...
  Rat   943 VLPNQQVASVQARDEDSEDNGIIKFSILKADFVPKDGATNPVQVFRISQSVEAGLYTGSIELVTN 1007

  Fly  1147 LDRESKDSYNLVIEAWDNYQFG-----------FLAGESRNAFKQVFISILDENDNPPEVDLPMS 1200
            ||...:.:|.:.::|.|.....           |...:|.....|...|..|...|..|:...:.
  Rat  1008 LDSTLQGTYQVTVQAQDQPAMDPALETQTTLNLFTVDQSYRVRLQFSTSREDVGANMEEIKAALI 1072

  Fly  1201 CVLITEYHELHERVASIVGKDADDPTTPNGRLD--FAITRG--------------NKDGMFELRQ 1249
            ....|..:     |.:|...|:......|..:|  |..:.|              ::|.:.:|.|
  Rat  1073 QATRTSVY-----VVTIQNIDSMARARVNSYMDAYFVFSNGSALTLTELNVMIRKDQDALRQLLQ 1132

  Fly  1250 IDAWNAQIFASKSLRNRYGNYSLTITTRDMGLPANIVHNTLDICVSDFNDHAPVFVRPLHNTTVR 1314
            :.     :....|...:..|.:..:|...:||..::| ..|.|.::     |.|..|..::..:|
  Rat  1133 LG-----LVVVSSQETQEFNQTQLLTNVIIGLVVSLV-LVLVIMIT-----ALVCFRKSYHRKLR 1186

  Fly  1315 ----------------IPENATVGTLILQAYASDGDMGQNALVRYRLKPDPLGSYKMFEVDGSTG 1363
                            .|..|..||   ..|.:|             :.:|:
  Rat  1187 AMKAGKEARKTPIETMTPAAAIPGT---NVYNTD-------------RANPM------------- 1222

  Fly  1364 ELFLKEQLNREKQKIHEIRIEAYDQGLPTSLSSDLDLTIYVRNVNDYEPQFMVNEISVNFTEHSD 1428
                             :.:...|.||....||||          ||.....::|.||:.
  Rat  1223 -----------------LDLPTKDLGLECHSSSDL----------DYHSLNSLDENSVDL----- 1255

  Fly  1429 PGSERIKLPDTIDKDQLELDDPNDTP---SQVCYFIVNGNEAG 1468
                     ||..|:....|.|::.|   |:.....::|..||
  Rat  1256 ---------DTDSKEFKRKDLPHNPPESDSEPLTAALSGRSAG 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad88C	NP_731930.3	Cadherin_repeat	76..168	CDD:206637	28/91 (31%)
		Cadherin_repeat	179..276	CDD:206637	32/110 (29%)
		Cadherin_repeat	287..388	CDD:206637	35/106 (33%)
		Cadherin_repeat	397..506	CDD:206637	36/124 (29%)
		Cadherin_repeat	514..617	CDD:206637	36/104 (35%)
		Cadherin_repeat	625..742	CDD:206637	41/116 (35%)
		Cadherin_repeat	751..853	CDD:206637	29/105 (28%)
		Cadherin_repeat	865..976	CDD:206637	17/110 (15%)
		Cadherin_repeat	985..1080	CDD:206637	18/98 (18%)
		Cadherin_repeat	1090..1191	CDD:206637	30/127 (24%)
		CA	1221..1302	CDD:214520	16/96 (17%)
		Cadherin_repeat	1312..1409	CDD:206637	15/112 (13%)
		Cadherin_repeat	1418..>1502	CDD:206637	13/54 (24%)
		Cadherin_repeat	1617..1710	CDD:206637
Cdhr2	XP_214434.4	Cadherin_repeat	33..121	CDD:206637	30/97 (31%)
		Cadherin_repeat	129..237	CDD:206637	32/115 (28%)
		Cadherin_repeat	247..350	CDD:206637	36/108 (33%)
		Cadherin_repeat	373..477	CDD:206637	31/105 (30%)
		Cadherin_repeat	486..583	CDD:206637	36/103 (35%)
		Cadherin_repeat	590..692	CDD:206637	41/116 (35%)
		Cadherin_repeat	700..804	CDD:206637	30/107 (28%)
		Cadherin_repeat	816..925	CDD:206637	35/219 (16%)
		Cadherin_repeat	936..1044	CDD:206637	26/107 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10886
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2641
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24028
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.060