DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad88C and Cdh23

DIOPT Version :9

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:XP_017169419.1 Gene:Cdh23 / 22295 MGIID:1890219 Length:3361 Species:Mus musculus


Alignment Length:1982 Identity:585/1982 - (29%)
Similarity:922/1982 - (46%) Gaps:286/1982 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 SSISIQVIILTTLISLVASNRPPRFAIDGQSEIVLRLKESPETKVGTLIYTLKGYDPD---NDPL 98
            |::.:.:.:|.      .::..|||  |..|:..:.:.|  :..||..:.|:|..|||   |..:
Mouse  1407 STVKVYITVLD------ENDNSPRF--DFTSDSAISVPE--DCPVGQRVATVKARDPDAGSNGQV 1461

  Fly    99 TFGKRNSHDSEIIRIENTGGNEAKIFLAKELDRELQDEYAIVLTLTD----SHYSDHNYVTQSFL 159
            .|...:.:.:....|..:..:..::|:||.||||..|.|.:.:..:|    ....||  :.|..:
Mouse  1462 VFSLASGNIAGAFEIITSNDSIGEVFVAKPLDREELDHYILKVVASDRGTPPRKKDH--ILQVTI 1524

  Fly   160 LLVEDINDNVPTF-LPYQNAIEIPEGSAPGV-VSTLEATDADEGAYGQVVYYLQELDGDNDV-FS 221
            |   |:|||.|.. .|:...:.:.|....|. |..:.|||.|.|....:.||:.|  |:.|: |.
Mouse  1525 L---DVNDNPPVIESPFGYNVSVNENVGGGTSVVQVRATDRDIGINSVLSYYITE--GNEDMTFR 1584

  Fly   222 IATHQGKGILRLQKELDYERKSLYQLRVLAIDRANQGPINTGTAAILVKVKDLEDQPPEF----V 282
            :....|: |.......|.||::.|.|.|...|...  |..:.|..:.|.:.|..|..|.|    .
Mouse  1585 MDRISGE-IATRPAPPDRERQNFYHLVVTVEDEGT--PTLSATTHVYVTIVDENDNAPVFQQPHY 1646

  Fly   283 EVQAVARIAEDAP--VGTKVLRVRAIDGDRGINNPIAYSLEANDL---FDINPHTGIVHTLTKLD 342
            ||     :.::.|  :.|.::.|:|:|.|.|.|..:.|::.|.::   |.||.|||::....:||
Mouse  1647 EV-----VLDEGPDTINTSLITVQALDLDEGPNGTVTYAIVAGNIINTFRINKHTGVITAAKELD 1706

  Fly   343 REEQSDQVNGAHILRISATELSKSNTQMAPTTVRTEVTVIVSDVNDEIPTFGETVYR--CEVNEN 405
            .|..    :|.:.|.::||:.....:....:|  |.|.|.|:|:||.:|||... |.  .:|.|.
Mouse  1707 YEIS----HGRYTLIVTATDQCPILSHRLTST--TTVLVNVNDINDNVPTFPRD-YEGPFDVTEG 1764

  Fly   406 AQTNTPLNFIDEEVQNVVFDHDEGNNGTFRLFL---DPPNDLFEIVPELAVNEANFMLRVKNSKS 467
            ........|:       ..|.|.|.||.....:   ||       :.|..::....:|||:....
Mouse  1765 QPGPRVWTFL-------AHDRDSGPNGQVEYSVVDGDP-------LGEFVISPVEGVLRVRKDVE 1815

  Fly   468 LDFEQFTEVNFTIFAREVDEPSRWSSAHVQIFIRDQNDNFPEFSQTIYNASVLENSEQDTIITHV 532
            ||.|.....|.||.||:...|...|:..|.|.:.|.|||.|.......|.::.|||...:.:.||
Mouse  1816 LDRETIAFYNLTICARDRGVPPLSSTMLVGIRVLDINDNDPVLLNLPMNVTISENSPVSSFVAHV 1880

  Fly   533 QAVDVDSGDYGTMGIRYTNLRGGIAHLLNLNPITGVITIKQAGGTAFDREIISRHYLTVEAIDNA 597
            .|.|.|||....:....|  .|.......:|..||::|:.:    ..|||.|..:.|||...||.
Mouse  1881 LASDADSGCNALLTFNIT--AGNRERAFFINATTGIVTVNR----PLDRERIPEYRLTVSVKDNP 1939

  Fly   598 GQ---GNRNTAQIIVDILDVNDNAPTFPQRQYETKLLENQAEFETPL-----QLEARDADLNGTE 654
            ..   ..::...::|.:.|.|||.|.|.:..|:.:::|| :...|||     .:.|.|||    |
Mouse  1940 ENPRIARKDFDLLLVSLADENDNHPLFTEGTYQAEVMEN-SPAGTPLTVLNGPILALDAD----E 1999

  Fly   655 N--SQVTYEIVEGLYRSNFTIDPQSGLLRPVHS---FDFEELVDGSSRRSDPYTGGSFSIREIDL 714
            :  :.|||::: |.:...|.||..:|:: .|.|   .|.|                :||...::|
Mouse  2000 DVYAVVTYQLL-GTHSDLFVIDNSTGVV-TVRSGIIIDRE----------------AFSPPFLEL 2046

  Fly   715 LVRARDSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFYAKTVPEDLPGGSSVLQVTAIDRDGSAPN 779
            |:.|.|.|  .|:....:.|.:.|.|||.|.|....|...:.|:.|.|.|||||||.|.| |..|
Mouse  2047 LLLAEDIG--QLNGTAHLFITILDDNDNWPTFSPPTYTVHLLENCPPGFSVLQVTATDED-SGLN 2108

  Fly   780 NVVVYRIQTGAGDKFIINSETGVISVAHGANLDPDLTESKRSLYTLSVIALDGGLGNSQLMTTCT 844
            ..:||||:.||.|:|:|:..||||.|.: |.:|.:..||    |.|:|:|.|  .|...|..|..
Mouse  2109 GELVYRIEAGAQDRFLIHPVTGVIRVGN-ATIDREEQES----YRLTVVATD--RGTVPLSGTAI 2166

  Fly   845 VNISIQDVN-NKPPVLKEMPALQILENTPVGTLVYRIQATDLDHKAILRYKLNPEHCEGRTEEGA 908
            |.|.|.|:| ::|..|..:..:.:||:...||::..:.|.|||....|.|.:.....:..|:.  
Mouse  2167 VTILIDDINDSRPEFLNPIQTVSVLESAEPGTIIANVTAIDLDLNPKLEYHIISIVAKDDTDR-- 2229

  Fly   909 LVKSSEYDFLGAFEVDSIEGTLKVVKLLDRERVEHIKLAITVEDLAA---AKGRQIAEGFLSIQV 970
            ||...|    .||.|:...|::.|...|:||.|...::.::|.|.|:   .....:....|::.:
Mouse  2230 LVPDQE----DAFAVNINTGSVMVKSPLNRELVATYEVTLSVIDNASDLPEHSVSVPNAKLTVNI 2290

  Fly   971 LDENDNNPKFR---LPFYRQSITENSINGAMIVNVLASDVDK--NRTITYALEG--NPTYRSLMH 1028
            ||.|||.|:|:   :.:|.:.:.|.:..|..::.|.|.|.||  |..|||.|..  .|.|..|. 
Mouse  2291 LDVNDNTPQFKPFGITYYTERVLEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLTPPGYVQLE- 2354

  Fly  1029 LDPQTGEIVVASKIDHEQHQWLNFSVRATDSGIPARSSLVDVYITVLDENDNNPYFVGGSKNYTI 1093
             |...|:::....:|:|:..||||:|||:|:|.|.|::.:.||:.::|.|||||.|...|....:
Mouse  2355 -DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAV 2418

  Fly  1094 SENAAPGTRVATLQAGDADSGDFGKITFLMDRISSQGKFTIDADTGVLTVADRLDRESKDSYNLV 1158
            .|:.|.||.:..:.|.|||||:|..|.:.:  :..:|||.|:.:||.::|...||||.||.|.|.
Mouse  2419 FEDIAVGTVILRVTATDADSGNFALIEYSL--VDGEGKFAINPNTGDISVLSSLDREKKDHYILT 2481

  Fly  1159 IEAWDNYQFGFLAGESRNAFKQVFISILDENDNPPEVDLPMSCVLITEYHELHERVASIVGKDAD 1223
            ..|.||.  |.:|...|....||.|.:||.||..|:...|.....:.|.......|.:::..|.|
Mouse  2482 ALAKDNP--GDVASNRRENSVQVVIRVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMLATDQD 2544

  Fly  1224 DPTTPNGRLDFAITRGNKDGMFELRQIDAWNAQIFASKSLRNRYGNYSLTITTRDMGLPANIVHN 1288
            :.:  |.:|.:::   ...|| |...:|..:..:...:.|:: |..::||:...|.|.|......
Mouse  2545 EGS--NSQLTYSL---EGPGM-EAFSVDMDSGLVTTQRPLQS-YERFNLTVVATDGGEPPLWGTT 2602

  Fly  1289 TLDICVSDFNDHAPVFVRPLHNTTVRIPENATVGTLILQAYASDGDMGQNALVRYR-LKPDPLGS 1352
            .|.:.|.|.||:.||||||.:.|.:.|.|...:.:.:.:.||:|.|.|.|..|||. ||......
Mouse  2603 MLLVEVIDVNDNRPVFVRPPNGTILHIKEEIPLRSNVYEVYATDNDEGLNGAVRYSFLKTTGNRD 2667

  Fly  1353 YKMFEVDGSTGELFLKEQLNREKQKIHEIRIEAYDQGLPTSLSSDLDLTIYVRNVNDYEPQFM-- 1415
            ::.|.:|..:|.:...::|:||||.::.:.:.|.|.|.|....:...|.:.:.:::|.||.|:  
Mouse  2668 WEYFTIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2732

  Fly  1416 ------VNEISVNFTEHSDPGSERIKLPDTIDKDQLELDDPNDTPSQVCYFIVNGNEAGYFRLDP 1474
                  ...::|  .|||..|:....:...:|.|    :.||   :.|.|||..|:|...|.|.|
Mouse  2733 PKGSPQYQLLTV--PEHSPRGTLVGNVTGAVDAD----EGPN---AIVYYFIAAGDEDKNFHLQP 2788

  Fly  1475 ETHILTVDRELDREVIANFTLYVRATENCRNDSISGGEKRRRMGIEINNRLGGIVHNQQFGYDRF 1539
            :..:|.: |:||||..|.|:..|:|:.|                                     
Mouse  2789 DGRLLVL-RDLDRETEATFSFIVKASSN------------------------------------- 2815

  Fly  1540 KHSRQLRSTESNEYGPEDA-ELLSYEAYDSSQEDPTGGLATTHPELDSTVIKVKVRVLDINDNPP 1603
                  ||. :...||..| :||:                      |.|:.:|:|.:.||||.||
Mouse  2816 ------RSW-TPPRGPSPALDLLT----------------------DLTLQEVRVVLEDINDQPP 2851

  Fly  1604 RFRSKIFTGGITTNADFGLKFMRVEATDADEGDNGRIGYYQVGEIR--QTLSEGLENVRKAPFLL 1666
            ||....:|.|:.|:|..|.:.::|.|.|||.|:|..: :|.:..|.  :.|:...|:|.:. |.:
Mouse  2852 RFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLV-FYGILAIHYFRALANDSEDVGQV-FTM 2914

  Fly  1667 DQETG-----EVQLNFDPQKGMKGYFDFVVLANDTSGMKDVAHVFIYLLREDQKVRFVFRLQPDE 1726
            ....|     ::.:.:.|     |||...::|.|.:|..|.|.:.||:||:||:|:.|....||.
Mouse  2915 GSVDGILRTFDLFMAYSP-----GYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIVINEIPDR 2974

  Fly  1727 LRSRVDSFRDTLSNITESIVNIDEIKVHENKDGSVDKTKTDLYMHLVEREDNSIYEVSEVLKLID 1791
            :|...:.|...|||||.:|||.|:::.|.:..|.|:..:|:|.:|:|.|:.|.|.:|..|:::||
Mouse  2975 VRGFEEEFIRLLSNITGAIVNTDDVQFHVDMKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMID 3039

  Fly  1792 SHIESLNGLFKELNVLDTQAAEAQLLTAGPSRGPLFVWLIFTNLFLATLLVVTIALCASQRNGY- 1855
            .:.|.|..||:..||||.|.|.:..|....|...:.:.::...||||.:|.|.:       |.| 
Mouse  3040 ENKEQLRNLFRNYNVLDVQPAISVQLPDDMSALQMAIIVLAILLFLAAMLFVLM-------NWYY 3097

  Fly  1856 ----RRQLRAAKVNIFRGHSSMSLQDAQEPATRVPNTNKHSVQGSNPIWLKGYDNEWFKSEESGS 1916
                :|:|:|...........:.:.|       :|||||:|..|:||:||    :.:.::.|..:
Mouse  3098 RTIHKRKLKAIVAGSAGNRGFIDIMD-------MPNTNKYSFDGANPVWL----DPFCRNLELAA 3151

  Fly  1917 IGGHDSLDDNFLAVATQDMHETLKGTAKLFNN 1948
            ...|:           .|:.|.|...|.|:|:
Mouse  3152 QAEHE-----------DDLPENLSEIADLWNS 3172

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637 26/98 (27%)
Cadherin_repeat 179..276 CDD:206637 27/98 (28%)
Cadherin_repeat 287..388 CDD:206637 29/105 (28%)
Cadherin_repeat 397..506 CDD:206637 29/113 (26%)
Cadherin_repeat 514..617 CDD:206637 29/105 (28%)
Cadherin_repeat 625..742 CDD:206637 34/126 (27%)
Cadherin_repeat 751..853 CDD:206637 45/101 (45%)
Cadherin_repeat 865..976 CDD:206637 30/113 (27%)
Cadherin_repeat 985..1080 CDD:206637 35/98 (36%)
Cadherin_repeat 1090..1191 CDD:206637 39/100 (39%)
CA 1221..1302 CDD:214520 20/80 (25%)
Cadherin_repeat 1312..1409 CDD:206637 26/97 (27%)
Cadherin_repeat 1418..>1502 CDD:206637 28/83 (34%)
Cadherin_repeat 1617..1710 CDD:206637 27/99 (27%)
Cdh23XP_017169419.1 Cadherin_repeat 51..137 CDD:206637
Cadherin_repeat 145..240 CDD:206637
Cadherin_repeat 249..353 CDD:206637
Cadherin_repeat 361..463 CDD:206637
Cadherin_repeat 472..564 CDD:206637
Cadherin_repeat 573..674 CDD:206637
Cadherin_repeat 683..781 CDD:206637
Cadherin_repeat 789..893 CDD:206637
Cadherin_repeat 901..997 CDD:206637
Cadherin_repeat 1006..1105 CDD:206637
Cadherin_repeat 1113..1210 CDD:206637
Cadherin_repeat 1225..1315 CDD:206637
Cadherin_repeat 1324..1421 CDD:206637 2/19 (11%)
Cadherin_repeat 1433..1530 CDD:206637 27/103 (26%)
Cadherin_repeat 1540..1637 CDD:206637 27/101 (27%)
Cadherin_repeat 1645..1747 CDD:206637 32/112 (29%)
Cadherin_repeat 1759..1854 CDD:206637 28/108 (26%)
Cadherin_repeat 1862..1962 CDD:206637 29/105 (28%)
Cadherin_repeat 1970..2072 CDD:206637 34/126 (27%)
Cadherin_repeat 2080..2176 CDD:206637 45/103 (44%)
Cadherin_repeat 2187..2296 CDD:206637 30/114 (26%)
Cadherin_repeat 2308..2405 CDD:206637 35/98 (36%)
Cadherin_repeat 2413..2511 CDD:206637 39/101 (39%)
Cadherin_repeat 2520..2614 CDD:206637 21/100 (21%)
Cadherin_repeat 2627..2725 CDD:206637 26/97 (27%)
Cadherin_repeat 2742..2848 CDD:206637 42/181 (23%)
Cadherin_repeat 2857..2958 CDD:206637 30/107 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 168 1.000 Domainoid score I3825
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007436
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

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