DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad88C and FAT2

DIOPT Version :9

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:NP_001438.1 Gene:FAT2 / 2196 HGNCID:3596 Length:4349 Species:Homo sapiens


Alignment Length:2243 Identity:517/2243 - (23%)
Similarity:868/2243 - (38%) Gaps:612/2243 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 LKESPETKVGTLIYTLKGYDPDNDPLTFGKRNSHDSEIIRIENTGGNEAKIFLAKELDRELQDEY 137
            :||:.:.:...:|...:| :..||.|::...|..|. ...:::.|..:.:   ....|||.||.:
Human  1977 VKENLQDRKALVILGAQG-NHLNDTLSYFLLNGTDM-FHMVQSAGVLQTR---GVAFDREQQDTH 2036

  Fly   138 AIVLTLTDSHYSDHNYVTQSFL-LLVEDINDNVPTF--LPYQNAIEIPEGSAPG-VVSTLEATDA 198
            .:.:.:.|:.....  |.|..: :.:||:|||.|.|  |||...|:  :|:.|| |:..:.|||.
Human  2037 ELAVEVRDNRTPQR--VAQGLVRVSIEDVNDNPPKFKHLPYYTIIQ--DGTEPGDVLFQVSATDE 2097

  Fly   199 DEGAYGQVVYYLQELDGDNDVFSIATHQGKGILRLQKELDYERKSLYQLRVLAID---------- 253
            |.|..|.|.|...|   |...|.|..:.|.  :.|:|..||:..:.|.|:|:|.|          
Human  2098 DLGTNGAVTYEFAE---DYTYFRIDPYLGD--ISLKKPFDYQALNKYHLKVIARDGGTPSLQSEE 2157

  Fly   254 --------RAN------------------------------------------------------ 256
                    ::|                                                      
Human  2158 EVLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKT 2222

  Fly   257 -----QGPIN-------------TGT-------AAILVKVKDLEDQPPEFVEVQAVARIAEDAPV 296
                 .||::             |.|       |.:.|.|:|:.|.||.|.::.....|:|..|.
Human  2223 GVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA 2287

  Fly   297 GTKVLRVRAIDGDRGINNPIAYSL-----EANDLFDINPHTGIVHTLTKLDREEQSDQVNGAHIL 356
            .|.|:::.|.|.|.|.|..::|.:     :.:..|.||..||.:.|:.:||.|.|..       .
Human  2288 QTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQH-------F 2345

  Fly   357 RISATELSKSNTQMAPTTVRTEVTVIVSDVNDEIPTFGETVYRCEVNENAQTNTPLNFIDEEVQN 421
            .:....:.|.:   .|.|..|.|.|.|||:||..|.|.:..|...|:|.|    ....:..:||.
Human  2346 HVKVRAMDKGD---PPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELA----TCGHLVLKVQA 2403

  Fly   422 VVFDHDEGNNGTFR---LFLDPPNDLFEIVPELAVNEANFMLRVKN--SKSLDFEQFTEVNFTIF 481
            :    |..:..|.|   |.|....|     ....:|.::.::.:.|  .|.||    :..|..:.
Human  2404 I----DPDSRDTSRLEYLILSGNQD-----RHFFINSSSGIISMFNLCKKHLD----SSYNLRVG 2455

  Fly   482 AREVDEPSRWSSAHVQIFIRDQNDN--FPEFSQTIYNASVLENSEQDTIITHVQAVDVDSGDYGT 544
            |.  |...|   |.|.::|...|.|  .|||.|.:|.|.:.||:...|.:..:.|:|.|||.|||
Human  2456 AS--DGVFR---ATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGT 2515

  Fly   545 MGIRYTNLRGGIAHLLNLNPITGVITIKQAGGTAFDREIISRHYLTVEAIDNAGQGNRNTAQIIV 609
              |.||.:....:...::||...:.|:::     .|||..:...:.::.:...|.|......:.:
Human  2516 --IDYTIINKLASEKFSINPNGQIATLQK-----LDRENSTERVIAIKVMARDGGGRVAFCTVKI 2573

  Fly   610 DILDVNDNAPTFPQRQYETKLLENQAEFETPLQLEARDADLNGTENSQVTYEI-VEGLYRSNFTI 673
            .:.|.|||.|.|...:|...:..|.::....:|:.|.|||..  :|:.|||.: .|.|.:....|
Human  2574 ILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEG--QNADVTYSVNPEDLVKDVIEI 2636

  Fly   674 DPQSGLLRPVHSFDFEELVDGSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYVQD 738
            :|.:|:::.                .|...|  ...:.:|..::|:|.|.|..:::|||.:.|..
Human  2637 NPVTGVVKV----------------KDSLVG--LENQTLDFFIKAQDGGPPHWNSLVPVRLQVVP 2683

  Fly   739 VNDNAPIFQQSFYAKTVPEDLPGGSSVLQVTAIDRDGSAPNNVVVYRIQTGAGDK------FIIN 797
            ...:.|.|.:..|..:.|||||.||.:..|.|:     |..:.|:|.:..|...:      |.::
Human  2684 KKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAV-----AAQDPVIYSLVRGTTPESNKDGVFSLD 2743

  Fly   798 SETGVISVAHGANLDPDLTESKRSLYTLSVIALDGGLGNSQLMTTCTVNISIQDVNNKPPVLKEM 862
            .:||||.|.  ..:|.:.|:    ||.:.|:|  ..|.|:.:::..:|||.:.|||:..||.:..
Human  2744 PDTGVIKVR--KPMDHESTK----LYQIDVMA--HCLQNTDVVSLVSVNIQVGDVNDNRPVFEAD 2800

  Fly   863 PALQIL-ENTPVGTLVYRIQATDLD--HKAILRYKLNPEHCEGRTEEGALVKSSEYDFLGAFEVD 924
            |...:| ||.||||.|.::.|.|.|  ....:.|:|:       .:.|:.|..       .|.:|
Human  2801 PYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS-------ADPGSNVHE-------LFAID 2851

  Fly   925 SIEGTLKVVKLLDRERVEHIKLAITVEDLAAAKGRQI---AEGFLSIQVLDENDNNPKFRLPFYR 986
            |..|.:..::.||.|..:.....:...|    .|:.|   ::..:.:.:.|||||.|:|....||
Human  2852 SESGWITTLQELDCETCQTYHFHVVAYD----HGQTIQLSSQALVQVSITDENDNAPRFASEEYR 2912

  Fly   987 QSITENSINGAMIVNVLASDVD---KNRTIT-YALEGNPTYRSLMHLDPQTG-EIVVASKIDHEQ 1046
            .|:.|||..|.::..:...|.|   :||.:| |..||:|..:..:   .|.| |..::|:...::
Human  2913 GSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGI---SQVGDEWRISSRKTLDR 2974

  Fly  1047 HQWLNFSVRATDSGIPARSSLVDVYITVLDENDNNP-----YFVGGSKNYTISENAAPGTRVATL 1106
            .....:.:|.|.|....::| |.|.|.|||.|||:|     .:.|     .:.|:..||..:..:
Human  2975 EHTAKYLLRVTASDGKFQAS-VTVEIFVLDVNDNSPQCSQLLYTG-----KVHEDVFPGHFILKV 3033

  Fly  1107 QAGDADSGDFGKITFLMDRISSQGKFTIDADTGVLTVADRLDRESKDSYNLVIEAWDNYQFGFLA 1171
            .|.|.|:....:||:.:....:. :|.:|..||.||....||||.||.:|||.:|.|        
Human  3034 SATDLDTDTNAQITYSLHGPGAH-EFKLDPHTGELTTLTALDRERKDVFNLVAKATD-------- 3089

  Fly  1172 GESRNAFKQVFISILDENDNPPEVDLPMSC-VLITEYHELHERVASIVGKDADDPTTPNGRLDFA 1235
            |..|:....:.:.:.|.|||.|.. .|..| |.:.:...:...||.:..:|.|...  |.::.::
Human  3090 GGGRSCQADITLHVEDVNDNAPRF-FPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151

  Fly  1236 ITRGNKDGMFELRQIDAWNAQIFASKSLRNR-YGNYSLTITTRDMGLPANI-VHNTLDICVSDFN 1298
            :. .:.:|.|   .|||....|...|.|:.| .....||:...|:|.|..: ...|:.:.|....
Human  3152 LP-DSAEGHF---SIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLE 3212

  Fly  1299 DHAPVFVRPLHNTTVRIPENATVGTLILQ--------------AYASDGDMGQNALVRYRLKPDP 1349
            |:.|||:...|  :|::||:|..||.:||              ...|..:.|:            
Human  3213 DYLPVFLNTEH--SVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGR------------ 3263

  Fly  1350 LGSYKMFEVDGSTGELFLKEQLNREKQKIHEIRIEAYDQGLPTSLSSDLDLTIYVRNVNDYEPQF 1414
                  |.:|..||.|::...|:.|....:.:.||. .:...:|||....:.:.:.:||::.|||
Human  3264 ------FRLDARTGILYVNASLDFETSPKYFLSIEC-SRKSSSSLSDVTTVMVNITDVNEHRPQF 3321

  Fly  1415 MVNEISVNFTEHSDPGSERIKLPDTIDKDQLELDDPNDTPSQVCYFIVNGNEAGYFRLDPETHIL 1479
            ..:..|....|::..|...:.:..|        |:.....|.:.|.::.||:.|:|.:.|:...|
Human  3322 PQDPYSTRVLENALVGDVILTVSAT--------DEDGPLNSDITYSLIGGNQLGHFTIHPKKGEL 3378

  Fly  1480 TVDRELDREVIANFTLYVRATENCRNDSISGGEKRRRMGIEINNRLGGIVHNQQFGYDRFKHSRQ 1544
            .|.:.||||..::::|.:|||::                                          
Human  3379 QVAKALDREQASSYSLKLRATDS------------------------------------------ 3401

  Fly  1545 LRSTESNEYGPEDAELLSYEAYDSSQEDPTGGLATTHPELDSTVIKVKVRVLDINDNPPRFRSKI 1609
                                           |....|.:.|     :.::|.|:|||||||....
Human  3402 -------------------------------GQPPLHEDTD-----IAIQVADVNDNPPRFFQLN 3430

  Fly  1610 FTGGITTNADFGLKFMRVEATDADEGDNGRIGYYQV------GEIRQT------LSEGL------ 1656
            ::..:..|:..|.|.:::..:|.|..:||....:::      ...|.|      .:|||      
Human  3431 YSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAEGLSRRAQE 3495

  Fly  1657 ---------------------------ENVRKAPFLLDQE----TGEVQL-----------NFDP 1679
                                       |....||..|..|    .||.:.           :.||
Human  3496 WYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDP 3560

  Fly  1680 Q-----------------------------KGM-KGYFDFVVLAND-----TSGMKDVAHVFIYL 1709
            |                             :|: :|::.|.|..:|     |:|:    ||:::.
Human  3561 QDTLTYSLAEEETLGRHFSVGAPDGKIIAAQGLPRGHYSFNVTVSDGTFTTTAGV----HVYVWH 3621

  Fly  1710 LRED--QKVRFV--FRLQPDELRSRVDSFRD-----------TLSNI-------TESIVNIDEIK 1752
            :.::  |:..::  ::|.|:||.|  |.:|:           ..:||       .|::..:|.:.
Human  3622 VGQEALQQAMWMGFYQLTPEELVS--DHWRNLQRFLSHKLDIKRANIHLASLQPAEAVAGVDVLL 3684

  Fly  1753 VHENKDGSVDKTKTDLYMHLVEREDNSIYEVSEVLKLIDSHIESLNGLFKELNVLDTQAAEAQLL 1817
            |.|...|                   :.||..|:..:|....:.:.      :.:..|...|..:
Human  3685 VFEGHSG-------------------TFYEFQELASIITHSAKEME------HSVGVQMRSAMPM 3724

  Fly  1818 TAGPSRGPLFVWLIFTNLF-----------LATLLVVT-------IALC---ASQRNG------- 1854
            .  |.:||.....|..|..           .|.|.::|       ...|   |::.:|       
Human  3725 V--PCQGPTCQGQICHNTVHLDPKVGPTYSTARLSILTPRHHLQRSCSCNGTATRFSGQSYVRYR 3787

  Fly  1855 -----------YRRQLRAAKVNIFRGH-SSMSLQDAQEPATRVPNTNKHSVQG-----SNPIWLK 1902
                       |.:.|:...:.:|... :|:||    :.|:.||....|.:.|     |:...:.
Human  3788 APAARNWHIHFYLKTLQPQAILLFTNETASVSL----KLASGVPQLEYHCLGGFYGNLSSQRHVN 3848

  Fly  1903 GYDNEWFK---SEESGSIG-GHDSLDDNFLAVATQ------DMHETLKGTAKLFNNSNDLNRHFN 1957
              |:||..   .|...||. ..||:.:..|.|...      :.|..|.|...|.::|| :::.|.
Human  3849 --DHEWHSILVEEMDASIRLMVDSMGNTSLVVPENCRGLRPERHLLLGGLILLHSSSN-VSQGFE 3910

  Fly  1958 LYNQIDKMTNNAQIL---------ARKLETTEL 1981
              ..:|.:..|.:.|         |..|||..|
Human  3911 --GCLDAVVVNEEALDLLAPGKTVAGLLETQAL 3941

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637 19/92 (21%)
Cadherin_repeat 179..276 CDD:206637 36/194 (19%)
Cadherin_repeat 287..388 CDD:206637 30/105 (29%)
Cadherin_repeat 397..506 CDD:206637 25/113 (22%)
Cadherin_repeat 514..617 CDD:206637 26/102 (25%)
Cadherin_repeat 625..742 CDD:206637 27/117 (23%)
Cadherin_repeat 751..853 CDD:206637 32/107 (30%)
Cadherin_repeat 865..976 CDD:206637 28/116 (24%)
Cadherin_repeat 985..1080 CDD:206637 31/99 (31%)
Cadherin_repeat 1090..1191 CDD:206637 29/100 (29%)
CA 1221..1302 CDD:214520 20/82 (24%)
Cadherin_repeat 1312..1409 CDD:206637 23/110 (21%)
Cadherin_repeat 1418..>1502 CDD:206637 22/83 (27%)
Cadherin_repeat 1617..1710 CDD:206637 31/187 (17%)
FAT2NP_001438.1 Cadherin_repeat 462..560 CDD:206637
Cadherin_repeat 570..659 CDD:206637
Cadherin_repeat 719..816 CDD:206637
Cadherin_repeat 825..921 CDD:206637
Cadherin_repeat 931..1026 CDD:206637
Cadherin_repeat 1038..1133 CDD:206637
Cadherin_repeat 1141..1238 CDD:206637
Cadherin_repeat 1247..1335 CDD:206637
Cadherin_repeat 1354..1444 CDD:206637
Cadherin_repeat 1453..1551 CDD:206637
Cadherin_repeat 1559..1650 CDD:206637
Cadherin_repeat 1664..1754 CDD:206637
Cadherin_repeat 1762..1867 CDD:206637
Cadherin_repeat 1887..1963 CDD:206637
Cadherin_repeat <1998..2066 CDD:206637 17/73 (23%)
Cadherin_repeat 2074..2163 CDD:206637 29/95 (31%)
Cadherin_repeat 2176..2268 CDD:206637 8/91 (9%)
Cadherin_repeat 2276..2375 CDD:206637 31/108 (29%)
Cadherin_repeat 2383..2475 CDD:206637 25/113 (22%)
Cadherin_repeat 2486..2581 CDD:206637 26/101 (26%)
Cadherin_repeat 2589..2682 CDD:206637 26/112 (23%)
Cadherin_repeat 2696..2793 CDD:206637 34/109 (31%)
Cadherin_repeat 2801..2902 CDD:206637 29/118 (25%)
Cadherin_repeat 2910..3007 CDD:206637 31/100 (31%)
Cadherin_repeat 3016..3109 CDD:206637 30/106 (28%)
Cadherin_repeat 3120..3209 CDD:206637 21/94 (22%)
Cadherin_repeat 3224..3317 CDD:206637 24/111 (22%)
Cadherin_repeat 3325..3422 CDD:206637 28/182 (15%)
Cadherin_repeat 3431..3522 CDD:206637 12/90 (13%)
Cadherin_repeat 3535..3619 CDD:206637 15/87 (17%)
Laminin_G_2 3800..3921 CDD:280389 30/129 (23%)
EGF_CA 3949..3984 CDD:238011
Cadherin_repeat 37..143 CDD:206637
Cadherin_repeat 152..247 CDD:206637
Cadherin_repeat 366..454 CDD:206637
EGF 3990..4020 CDD:278437
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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