DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad88C and FAT1

DIOPT Version :9

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:XP_005262891.1 Gene:FAT1 / 2195 HGNCID:3595 Length:4600 Species:Homo sapiens


Alignment Length:2200 Identity:513/2200 - (23%)
Similarity:858/2200 - (39%) Gaps:589/2200 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 LTTLISLVASNRPPRFAIDGQSEIVLRLKESPETKVGTLIYTLKGYDPDNDPLTFGKRNSH---- 106
            |..::.:.|::.||.|.   |....:.:.|..|  |.:.|..::..|.|..|      |.|    
Human   807 LLHVVVVDANDNPPEFL---QESYFVEVSEDKE--VHSEIIQVEATDKDLGP------NGHVTYS 860

  Fly   107 ---DSEIIRIENTGGNEAKIFLAKELDRELQDEYAIVLTLTDSHYSDHN-YVTQSFLLLVEDIND 167
               |::...|::..|   .:.:|:.||||||.|:::.:...|....:.. :.|....:.:||:||
Human   861 IVTDTDTFSIDSVTG---VVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVND 922

  Fly   168 NVPTFLP--YQNAI--EIPEGSAPGVVSTLEATDADEGAYGQVVY-YLQELDGDNDVFSIATHQG 227
            |.|||:|  |:..:  ::|||:   |:..|||.|.|.|..|||.| .|...:|:.||..::    
Human   923 NPPTFIPPNYRVKVREDLPEGT---VIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLS---- 980

  Fly   228 KGILRLQKELDYERKSLYQLRVLAIDRANQGPIN-TGTAAILVKVKDLED--QPPEFVEVQAVAR 289
             |.:|:.::||:|:|.:|.|.|.|.|:..  |:: :.|..:.|:|.|:.:  .||.|........
Human   981 -GAVRIVQQLDFEKKQVYNLTVRAKDKGK--PVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGT 1042

  Fly   290 IAEDAPVGTKVLRVRAIDGDRGINNPIAYSLEAND---LFDINPHTGIVHTLTKLDREEQSDQVN 351
            :.||||||:.|:.|.|.|.|...:..|.||:....   :|.|...||::.|..:||||..|.   
Human  1043 VKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSH--- 1104

  Fly   352 GAHILRISATELSKSNTQMAPTTVRTEVTVIVSDVNDEIPTFGETVYRCEVNENAQTNTPLNFID 416
              :.|.:.||:..     :.|.:...|:.:.|.||||..|...|.||..|:.||:..:..:    
Human  1105 --YWLTVFATDQG-----VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---- 1158

  Fly   417 EEVQNVVFDHDEGNNG--TFRLFLDPPNDLFEIVPELAVNEANFMLRVKNSKSLDFEQFTEVNFT 479
              ||...||.|..:|.  .:::....|...|.|.|:..       |....|:.||.||..|....
Human  1159 --VQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTG-------LITTTSRKLDREQQDEHILE 1214

  Fly   480 IFAREVDEPSRWSSAHVQIFIRDQNDNFPEFSQTIYNASVLENSEQD-------TIITHVQAVDV 537
            :...:...|.:.:.|.|.:.|.|:|||.|:|.|..|...:.|..:.|       ..:.||.|.|.
Human  1215 VTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279

  Fly   538 D------------------------------------SGDYGTMGIR------------------ 548
            |                                    :|:|..:.|:                  
Human  1280 DEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIE 1344

  Fly   549 --------------------YTNLRGG-IAHLLNLNPITGVITIKQAG----------------- 575
                                :|.:... :||::      |||:::..|                 
Human  1345 WISKPKPSLEPISFEESFFTFTVMESDPVAHMI------GVISVEPPGIPLWFDITGGNYDSHFD 1403

  Fly   576 ---GTA-------FDREIISRHYLTVEAIDNAGQGNRNTAQIIVDILDVNDNAPTFPQRQYETKL 630
               ||.       .|.|..|.:.|||||.|..   .....|:.:.::|.||:.|.|...:||..:
Human  1404 VDKGTGTIIVAKPLDAEQKSNYNLTVEATDGT---TTILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465

  Fly   631 LENQAEFETPLQLEARDADLNGTENSQVTYEIV---EGLYRSNFTIDPQSGLLRPVHSFDFEELV 692
            .|:.|.....||:.|.|.|    |.:::.|.:.   :.|....|.:||.:|.|......|.|   
Human  1466 PEDTAPETEILQISAVDQD----EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHE--- 1523

  Fly   693 DGSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFYAKTVPE 757
                           ::.:..|.|..||..:|:......:::.|.|.||:||.|..|.|...|.|
Human  1524 ---------------AVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYE 1573

  Fly   758 DLPGGSSVLQVTAIDRDGSAPNNVVVYRIQTG-AGDKFIINSETGVISVAHGANLDPDLTESKRS 821
            ....||.||||||:|:| ...|..|:|.|::| .|:.|:|:...|.|..|      .:|..|.::
Human  1574 SAAVGSVVLQVTALDKD-KGKNAEVLYSIESGNIGNSFMIDPVLGSIKTA------KELDRSNQA 1631

  Fly   822 LYTLSVIALDGGLGNSQLMTTCTVNISIQDVNNKPPVLKEMPALQILENTPVGTLVYRIQATDLD 886
            .|.|.|.|.|.|......:|:..:.::|.| |..|....:..::::.|...:|:.|..:.|   .
Human  1632 EYDLMVKATDKGSPPMSEITSVRIFVTIAD-NASPKFTSKEYSVELSETVSIGSFVGMVTA---H 1692

  Fly   887 HKAILRYKLNPEHCEGRTEEGALVKSSEYDFLGAFEVDSIEGTLKVVKLLDRERVEHIKLAITVE 951
            .::.:.|::.    :|.|.:             ||:::...||:...|.||.|.:....|.|...
Human  1693 SQSSVVYEIK----DGNTGD-------------AFDINPHSGTIITQKALDFETLPIYTLIIQGT 1740

  Fly   952 DLAAAKGRQIAEGFLSIQVLDENDNNPKFRLPFYRQSITEN-SINGAMIVN------VLASDVDK 1009
            ::|...    ....:.:.:.|||||.|.|....|...|:|: |||..::.:      :.|:|.||
Human  1741 NMAGLS----TNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADK 1801

  Fly  1010 --NRTITYALEGNPTYRSLMHLDPQTGEIVVASKIDHEQHQWLNFSVRATDSGIPA--RSSLVDV 1070
              |..:.|.:. .|:..:...:|..||.|.....:|:|:....:|:|:..|.|.|.  .....:|
Human  1802 DSNALLVYHIV-EPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANV 1865

  Fly  1071 YITVLDENDNNPYFVGGSKNYTISENAAPGTRVATLQAGDADSGDFGKITFLMDRISSQGKFTID 1135
            .:.|:|.||..|.|.......::......|.:|.|:.|.||||..|.::.:.:...:...||::|
Human  1866 TVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMD 1930

  Fly  1136 ADTGVLTV--------------------------------------------------------- 1143
            ..||.|||                                                         
Human  1931 YKTGALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEA 1995

  Fly  1144 -----------------------ADR-----------------LDRESKDSYNLVIEAWDNYQFG 1168
                                   .||                 .|||.::::::|:|..:.::  
Human  1996 ETLAVITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHK-- 2058

  Fly  1169 FLAGESRNAFKQVFISIL--DENDNPPE-VDLPMSCVL--------------------------- 1203
                  .:|...|.:.::  |:|||.|. |:||...|:                           
Human  2059 ------PSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNGEVH 2117

  Fly  1204 --ITEYHELH----------------------ERVASIVGKDADDP------------------- 1225
              :.|:|| |                      |.:.::|.||..:|                   
Human  2118 YYLKEHHE-HFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVMNKAMPV 2181

  Fly  1226 -------------------------TTPNG-RLDFAITRGNKDGMFELRQIDAWNAQIFASKSLR 1264
                                     .:|.| ::.::||.|:....|.: ..:.....:.|.... 
Human  2182 FEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTI-NFNTGVINVIAPLDF- 2244

  Fly  1265 NRYGNYSLTITTRD--MGLPANIVHNTLDICVSDFNDHAPVFVRPLHNTTVRIPENATVGTLILQ 1327
            ..:..|.|:|...|  .|..|.:.   :||.|.|.||:.|||.:  .:..|.:.|.:.:||.::|
Human  2245 EAHPAYKLSIRATDSLTGAHAEVF---VDIIVDDINDNPPVFAQ--QSYAVTLSEASVIGTSVVQ 2304

  Fly  1328 AYASDGDMGQNALVRYRLKPDPLGSYKMFEVDGSTGELFLKEQLNREKQKIHEIRIEAYDQGLPT 1392
            ..|:|.|...|..:.|::..:...|:..|.||.|||.:.|...|:.|:.:.|.|.:.|.|.|:||
Human  2305 VRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPT 2369

  Fly  1393 SLSSDLDLTIYVRNVNDYEPQFMVNEISVNFTEHSDPGSERIKLPDTIDKDQLELDDPNDTPSQV 1457
             ||||:.:|:.|.::||..|.|.........:||: |....:......|.|..::|       ::
Human  2370 -LSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHA-PHGHFVTCVKAYDADSSDID-------KL 2425

  Fly  1458 CYFIVNGNEAGYFRLDPETHILTVDRELDREVIANFTLYVRATENCRNDSISGGEKRRRMGIEIN 1522
            .|.|::||:..:|.:|..|.|:|:. .|.|..:..|        ...|.|:|.|..|....:.: 
Human  2426 QYSILSGNDHKHFVIDSATGIITLS-NLHRHALKPF--------YSLNLSVSDGVFRSSTQVHV- 2480

  Fly  1523 NRLGGIVHNQQFGYDRFK---------HS--RQLRST--ESNEYGPEDAELLSYEAYDSSQEDPT 1574
            ..:||.:|:..|..:.::         |:  .::::|  :|..||.....:::..|.|....:..
Human  2481 TVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINER 2545

  Fly  1575 GGLATTHPELD-----STVIKVK----------------VRVLDINDNPPRFRSKIFTGGITTNA 1618
            |.:.|.. :||     ..||.|:                |.:.|.|||.|:||:..:...|.::|
Human  2546 GQIFTLE-KLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSA 2609

  Fly  1619 DFGLKFMRVEATDADEGDNGRIGYYQVGEIRQTLSEGLENVRKAPFLLDQETGEVQLNFDPQKGM 1683
            ..|...::|.|:|||||.|..| .|.:....:::.|.|| :.|...::..:...:.|..:     
Human  2610 AKGTSVVKVLASDADEGSNADI-TYAIEADSESVKENLE-INKLSGVITTKESLIGLENE----- 2667

  Fly  1684 KGYFDFVVLA--NDTSGMKDVAHVFIYLLREDQKVR------FVFRLQPD-ELRSRVDSFRDTLS 1739
              :|.|.|.|  |.:...:.|..|::.:|..:.::.      :.|.:..| .:.:.:|..|...|
Human  2668 --FFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHS 2730

  Fly  1740 ----------NITESIVNIDEIKVHENKDG------SVDKTKT---------------------- 1766
                      |..||  |.||..|.:.:.|      |:|...|                      
Human  2731 GTVLYSLVKGNTPES--NRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASV 2793

  Fly  1767 DLYMHLVEREDNS-IYEVSEVLKLIDSHIESLNGLFKELNVLDTQAAEAQLLTAG 1820
            |:.:.:.:..||| ::|.|.....|   :|:|.|   ...|:..:|::|...|.|
Human  2794 DVSIQVKDANDNSPVFESSPYEAFI---VENLPG---GSRVIQIRASDADSGTNG 2842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637 24/99 (24%)
Cadherin_repeat 179..276 CDD:206637 34/100 (34%)
Cadherin_repeat 287..388 CDD:206637 32/103 (31%)
Cadherin_repeat 397..506 CDD:206637 28/110 (25%)
Cadherin_repeat 514..617 CDD:206637 32/211 (15%)
Cadherin_repeat 625..742 CDD:206637 27/119 (23%)
Cadherin_repeat 751..853 CDD:206637 35/102 (34%)
Cadherin_repeat 865..976 CDD:206637 21/110 (19%)
Cadherin_repeat 985..1080 CDD:206637 28/105 (27%)
Cadherin_repeat 1090..1191 CDD:206637 28/199 (14%)
CA 1221..1302 CDD:214520 21/127 (17%)
Cadherin_repeat 1312..1409 CDD:206637 33/96 (34%)
Cadherin_repeat 1418..>1502 CDD:206637 18/83 (22%)
Cadherin_repeat 1617..1710 CDD:206637 24/94 (26%)
FAT1XP_005262891.1 Cadherin_repeat 38..144 CDD:206637
Cadherin_repeat 153..252 CDD:206637
E_set 277..356 CDD:298831
Cadherin_repeat 371..459 CDD:206637
Cadherin_repeat 468..565 CDD:206637
Cadherin_repeat 575..663 CDD:206637
Cadherin_repeat 724..818 CDD:206637 2/10 (20%)
Cadherin_repeat 826..923 CDD:206637 25/107 (23%)
Cadherin_repeat 932..1016 CDD:206637 31/93 (33%)
Cadherin_repeat 1042..1135 CDD:206637 33/102 (32%)
Cadherin_repeat 1143..1241 CDD:206637 28/110 (25%)
Cadherin_repeat 1250..1344 CDD:206637 11/93 (12%)
Cadherin_repeat 1363..1452 CDD:206637 21/97 (22%)
Cadherin_repeat 1461..1558 CDD:206637 27/118 (23%)
Cadherin_repeat 1566..1658 CDD:206637 33/98 (34%)
Cadherin_repeat 1671..1761 CDD:206637 21/113 (19%)
Cadherin_repeat 1769..1874 CDD:206637 27/105 (26%)
Cadherin_repeat 1895..1970 CDD:206637 17/74 (23%)
Cadherin_repeat 1983..2077 CDD:206637 11/101 (11%)
Cadherin_repeat 2085..2174 CDD:206637 11/89 (12%)
Cadherin_repeat 2187..2279 CDD:206637 18/96 (19%)
Cadherin_repeat 2287..2386 CDD:206637 34/99 (34%)
Cadherin_repeat 2394..2488 CDD:206637 25/111 (23%)
Cadherin_repeat 2496..2592 CDD:206637 17/96 (18%)
Cadherin_repeat 2601..2694 CDD:206637 25/101 (25%)
Cadherin_repeat 2708..2805 CDD:206637 17/98 (17%)
Cadherin_repeat 2813..2913 CDD:206637 8/35 (23%)
Cadherin_repeat 2922..3019 CDD:206637
Cadherin_repeat 3028..3121 CDD:206637
Cadherin_repeat 3129..3226 CDD:206637
Cadherin_repeat 3234..3331 CDD:206637
Cadherin_repeat 3339..3436 CDD:206637
Cadherin_repeat 3445..3536 CDD:206637
Cadherin_repeat 3561..3634 CDD:206637
LamG 3854..3985 CDD:214598
EGF_CA 4016..4050 CDD:238011
EGF_CA 4053..4088 CDD:238011
EGF 4093..4123 CDD:278437
EGF_CA 4127..4163 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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