DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cad88C and cdh-1

DIOPT Version :9

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:NP_497641.2 Gene:cdh-1 / 187783 WormBaseID:WBGene00019994 Length:2779 Species:Caenorhabditis elegans


Alignment Length:2591 Identity:538/2591 - (20%)
Similarity:883/2591 - (34%) Gaps:887/2591 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 IDSMDYKKVRLKGQRRRSF--------------SSYISSISIQVIILTTLISLVASNRP------ 58
            |::.|..|....||.|.|.              |.|.:|:|..:.|.:.||::.|::..      
 Worm   203 IEAQDGGKPAKIGQLRCSIEIIDANDNAPVFSRSRYTASVSANISIGSHLITVQATDADIGENSR 267

  Fly    59 -------------PRFAIDGQSEIVLRLKE-----------------SPETKVGTLI-YTLKGYD 92
                         ..||| .||.::.....                 ||......:: .|:.|..
 Worm   268 ISYDIKKTSAPSNSNFAI-SQSGVITTTASLLPASTHDVIVVASDHGSPSLSSSAVVTITVLGST 331

  Fly    93 PDNDPL-TFGKRNSHDSEIIRIENTGGNEAKIFLAKE---------------------------- 128
            ..:.|| ......|:.:.::.....|...|::.:|::                            
 Worm   332 LSSPPLDIIWLVESNSAHLMENSTLGSIVARVSIAQQYRDTKLRLIGSSALCPQQTDQAHVYLLL 396

  Fly   129 ----LDRELQDEYAIVLTLTDSHYSDHNYVTQ-SFLLLVEDINDNVPTFLPYQNAIEIPEGSAPG 188
                ||||...|:.:...|.    .|...:.: ..||.:.|||||.|.:  :.:.|.|......|
 Worm   397 LCGILDRETASEHHLKFLLE----KDGQIIIEHPQLLTIGDINDNAPQW--HSSQIHISLNRTQG 455

  Fly   189 VVSTLEATDADEGAYGQVVYYLQELDGDNDVFSIATHQGKGILRLQKELDYERKSLYQLRVLAID 253
            ...||.|.|.|.|..|.:.|.:.    |.::.||....|:  :.:...:|....|..:.||.|.|
 Worm   456 GSRTLTAKDPDLGQNGWIRYSVL----DTELVSIDKETGR--IFVPNTIDCNIGSEIKFRVRAED 514

  Fly   254 RANQGPINTGTAAILVKVKDLEDQPPEFVEVQAVARIAEDAPVGTKVLRVRAIDGDRGINNPIAY 318
            ..:  |..:....::..:.|.|.:||:|.:......|.||.|:||.:::|.|.:...|.:..|.|
 Worm   515 GGS--PALSTDLQVVADLLDTESKPPQFEKALWQVEIPEDTPIGTCLVKVVANNSQCGNSKRIRY 577

  Fly   319 SLEAND-LFDINPHTGIVHTLTKLDREEQSDQVNGAHILRISATEL-SKSNTQMAPTTVRTEVTV 381
            ||:..| ...::..:|.|......|.|:|.     ::...:.||.. |:::|.:        :::
 Worm   578 SLQNQDEHLTVDTMSGTVCIQKTFDFEKQK-----SYQTTVIATNANSETSTSL--------ISI 629

  Fly   382 IVSDVNDEIPTFGETVYRCEVNENAQTNTPLNFIDEEVQNVVFDHDEGNNGTFRLFLDPPNDLFE 446
            .:.||||..|.|....|...|.|..:...||..:...      |.|.|..|.....:...:..|.
 Worm   630 RLKDVNDNWPIFYPNEYHLTVREGPKPEEPLLVVSAS------DMDSGTFGEVSYHILSESSSFS 688

  Fly   447 IVP---------------------------ELAVNEANFMLRV--KNSKSLDFEQ---------- 472
            |.|                           :.:.|.||..:.|  |::|:..|.:          
 Worm   689 INPVTGEVFAQKPLARGRFHLVVSAKDGGGQSSENSANIHITVIDKDTKTPQFSRSKYEIRTTED 753

  Fly   473 ------------FTEVNFTIFARE------VDE---------------------------PSRWS 492
                        .::|.::|::.:      :||                           ||..|
 Worm   754 ILPGIAIGSVGAMSKVKYSIYSGDQDHNFSIDEDTGKIYVTRYLDADVHDTVLLNIQATLPSGES 818

  Fly   493 S-AHVQIFIRDQNDNFPEFSQTIYNASVLENSEQDTIITHVQAVDVDSGDYGTMGIRYTNLRGGI 556
            : ..|.|||.|.|||.|:||.::...|:.|:.:.......|||.|.|....|.  :||:.:....
 Worm   819 NQTQVVIFIEDHNDNPPQFSSSLVEISIREDLKLHEPFYVVQASDKDKKKNGE--VRYSIISSHP 881

  Fly   557 AHLLNLNPITGVITIKQAGGTAFDREIISRHYLTVEAIDNAGQGNRNTAQIIVDILDVNDNAPTF 621
            ...:.::..||.::.    |:..|.|....:.|.|:|.|.......:...:.:.:||||||||.|
 Worm   882 GSSIEIDQFTGQLST----GSLLDYEATRNYKLRVKATDLGIPPRSSNMTLFIHVLDVNDNAPEF 942

  Fly   622 PQRQYETKLLENQAEFETPLQLEARDADLNGTENSQVTYEIVEGLYRSNFTIDPQSGLLRPVHSF 686
            .:..|..::|||........::.|||.|  ..||.|:.|.|..|  ...|.||.:.|.:....|.
 Worm   943 EKSWYTMEVLENSPPKTIVGKVVARDKD--SLENGQIVYRITNG--SEYFGIDEKLGNVYTKRSI 1003

  Fly   687 DFEELVDGSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFY 751
            |.|                  .|..:|:.:.|.|.|:|..|:.....|.|.|||||.|.. .|..
 Worm  1004 DRE------------------VISHVDISIVAEDKGVPPRSSTASARISVLDVNDNPPSC-LSIT 1049

  Fly   752 AKTVPEDLPGGSSVLQVTAIDRDGSAPNNVVVYRIQTGAGDKFIINSETGVISVAHGANLDPDLT 816
            ...||...|..:::..:.|:|.| ...|..|:||.|. ....|::.|...|.       |...|.
 Worm  1050 PIVVPAGSPLSTAIGTIVAMDPD-KGLNGSVLYRAQL-QSSLFVVKSNGDVY-------LRRQLN 1105

  Fly   817 ESKRSLYTLSVIALDGGL---------------GNSQLM----------------TTC---TVN- 846
            .|......||||..|.|:               |::.:.                |.|   |:| 
 Worm  1106 ASDERHQRLSVIVSDQGVPRKSVVCHVPVRISKGSADIQIQEPFQKYIEIPKSCPTGCRLTTLNA 1170

  Fly   847 -------ISIQDVNN-----------------KPP-----VLKEM-------------------- 862
                   |...:::|                 :||     ||.:.                    
 Worm  1171 TGVSSWLIQSSEISNHFAIREGVLFMISHPIHRPPYSLVIVLSDKNDRQKSIQLRVLASGEAANK 1235

  Fly   863 -PALQILENTPVGTLVYRIQATDLDHKAILRYKLNPEHCEGRTEE-GALV-------KSSEYDFL 918
             ..::|.::..:||.:.|:.....|.....|:. :.|.|....:: |.|:       :...::|.
 Worm  1236 EETIRISDSNSIGTKIGRLGEKSADGSFFYRFS-SEESCPLELDQTGGLLYLADGLRRGDTHNFS 1299

  Fly   919 GAFE-VDSIEGTLKVVKL--------LDRERVE--HIKLAI---------------TVEDLAAA- 956
            ..|| .::.:|:.:.:::        .|:.|.:  |:::.|               ||.|.:|: 
 Worm  1300 CFFEKFNTTDGSAEEMRVDLEISRTKSDKPRFDTGHLRVNIREDTPTGSIITTVNATVSDDSASP 1364

  Fly   957 ---------------------------------KGRQIAEGFLS---------IQVLDEND---- 975
                                             ....|.|.|.|         :.|.|.||    
 Worm  1365 ISYRFPLLIDNFSIDQFTGDITLIDTLHWHVTPTYNLIVEAFTSGPGTTLLVTVNVDDVNDHTPF 1429

  Fly   976 --NNPKFRLP-FYRQSITENSINGAMIVNVLASDVDKNRTITYALE--GNPTYRSLMHLDPQTGE 1035
              :.|...|| .||:        |.|:..|:|.|:||:..|.|:|:  |:...:....:|.::||
 Worm  1430 IVSQPTVLLPSSYRK--------GGMVHRVVAIDLDKDPEIRYSLKYAGSEVAKEFFKIDEKSGE 1486

  Fly  1036 IVVA-----------------------------SKIDHE----------QHQWLNFSVRATD--- 1058
            |.|.                             :|.|.:          :..|..|..:..|   
 Worm  1487 IFVVESSSALSTSFGGAGLPETLTIRATDLQDLTKFDEQKVLLKASNASRSTWHFFDEQHKDVTI 1551

  Fly  1059 -SGIPARSSL--------VDVYITVLDENDNNPYF-VGGSKNYTISENAAPGTRVATLQAGDADS 1113
             |..|..|.:        ||:.:.     .::|:| :..||....|.:.|.||:..|:.|...|.
 Worm  1552 LSTSPQGSQILQLKFQEGVDLQLI-----PSSPHFELKSSKIVQKSASVATGTQRFTIVAQKDDE 1611

  Fly  1114 GDFGKITFLMD-------RISS---------------------------------QG---KFTID 1135
            .|:..:...::       :|||                                 ||   ||:|:
 Worm  1612 LDYSTLKIHVEPVFTEPPKISSTSCGVVTIEENVGIEDFKRILATGMTEESRFRFQGNAPKFSIN 1676

  Fly  1136 ADTGVLTVADRLDRESKDSYNLVIEAWDNYQFGFLAGESRNAFKQVFISILDENDNPPEVDLPMS 1200
            :.||.::|.. ||||:...:.|:|...|        |.|||....|.:::.|:|||.|::|....
 Worm  1677 STTGSISVLP-LDREASQEHLLIIILTD--------GGSRNDSCTVRVTVADQNDNKPQLDASTP 1732

  Fly  1201 CVLITEYHELHE--RVASIVG--KDADDPTTPNGRLDFAI---TRGNKD-----GMFELRQ---I 1250
            ..|     |:.|  ||..::.  :.:|.....||:..|.:   :.|:.|     |...||:   :
 Worm  1733 SEL-----EIAESSRVGDVLHRFRASDMDIGQNGKFSFELLEDSSGSLDLVPETGDLVLRRLSSL 1792

  Fly  1251 DAWNAQ----------IFASKSLR--NRYGNYSLT----------ITTRDMGLP----------- 1282
            .:|..:          ::..|:|.  ||.......          ::|.|.|||           
 Worm  1793 QSWKIKLRVVDHGVPGLYVEKNLEISNRNPQTEAKAPLEFLKQTYLSTIDEGLPRGQFIAKLQPE 1857

  Fly  1283 ----------ANI--------------------------------------VHNTLDICVSDFND 1299
                      .||                                      :...:|:.|::.||
 Worm  1858 LAGLTYSIVEGNIDSAFSVDSEGVIRTNLELDREILERYSLKVIGTGSGQQIGTRVDVRVNNLND 1922

  Fly  1300 HAPVFVRPLHNTTVRIPENATVGTLILQAYASDGDMGQNALVRYRLKPDPLGSYKM-FEVDGSTG 1363
            :.|.|  |:.... |:|||..||:.:....|.|.|  ..|.:||.|..|..|.... |.:|..||
 Worm  1923 NVPSF--PMSKPR-RVPENLRVGSYVATVGAKDVD--NLAPLRYFLVSDSSGQTPTHFNIDQFTG 1982

  Fly  1364 ELFLKEQLNREKQKIHEIRIEAYDQGLPTSLSSDLDLTIYVRNVNDYEPQFMVNEISVNFTEHSD 1428
            .:.|...|:.|....|.:.|:|.|    .|..:..:|||:|.::||..|.|            |.
 Worm  1983 TIHLTAPLDFEVLPEHTLTIKATD----GSFDTFTNLTIFVSDINDNAPTF------------SK 2031

  Fly  1429 PGSERIKLPDTIDKDQ----LELDDPNDTPSQVCYFIVNGNEAGYFRLDPETHILTVDRELDREV 1489
            |..:....|.|....|    :|..| .|....:.|.:..|: :..||:.||:..|.:      :|
 Worm  2032 PLYQTTVSPATFSPGQPFAKIEAHD-LDARGALTYSLGQGS-SSIFRVAPESGALFM------KV 2088

  Fly  1490 I----ANFTLYVRATEN-----------------CRNDSISGGEKRR-RMGIEINNRLGGIVHNQ 1532
            :    ..:.:.|.||:|                 .......|.||.. |..:..|:::|..:.| 
 Worm  2089 LPPAGERYLVTVTATDNGVPSFSTSVPVSVIIGEAEPTDKPGFEKAEFRFEVMENSKIGLQIGN- 2152

  Fly  1533 QFGYDRFKHSRQLRSTESNEY-----GPEDAELLSYEAY---------DSSQEDPTGGLATTHP- 1582
                        |...||.|:     .||.:::.|.:.:         |..|.       .||. 
 Worm  2153 ------------LSGEESREFHYRIQDPEASKIFSIDKFGRLFVAGPIDREQR-------ATHEF 2198

  Fly  1583 --ELDSTVI-------KVKVRVLDINDNPPRFRSKIFTGGITTNADFGLKFMRVEATDADEGDNG 1638
              |:|:.::       |..|.|||.|||.|.|.|..:...:..:...|.|..::.|:|.|.|:||
 Worm  2199 QVEIDNEMMTSQKVQCKCHVIVLDENDNLPVFTSVAYYLSLKDSMAHGQKIGQIMASDQDSGENG 2263

  Fly  1639 RIGYYQVGEIRQTLSEGLENVRKAPFLLDQETGEVQLN--FDPQ--------------------- 1680
            |:.|       :.||....|:    ..|:.:||.:|||  .|.|                     
 Worm  2264 RVSY-------RILSGNDLNI----VTLNPDTGSIQLNEWNDAQLDEFPNATWQILVEARDHGHP 2317

  Fly  1681 --------------KGMKGYFDFVVL-------ANDTS--------------GMKDVAHVFIYLL 1710
                          ....|...|.||       ..|||              ||::..  .:|.|
 Worm  2318 ARAAVGKVQVSLKMSSWSGSAPFFVLPVYEVHVLEDTSVGTVLQKIRASNRLGMRNDG--LLYSL 2380

  Fly  1711 REDQ--------------KVRFVFRLQP----------DELRSR----------VDSFRD--TLS 1739
            :|.|              |....:..:|          ...||.          ||.|..  |.|
 Worm  2381 KEHQGKLGIDVKTGELTLKTHLDWESEPIISMYLSVSDGNGRSAVVPLKIVVEPVDEFAPVFTKS 2445

  Fly  1740 NIT----------ESIVNIDEIKVHENKDGSV---------DKTKT----------DLYMHLVER 1775
            :.|          ||:..:..|    ::||.|         |:..|          .|...||.|
 Worm  2446 SYTLQIPISTPAGESVGQMQAI----DEDGGVHGVVKYSISDRQSTVKIEEHTGIIRLQKPLVSR 2506

  Fly  1776 EDNSIYEVSEVLKLIDSHIESLNGLFKELNVLDTQAAEAQLLTAGPSRGPLFVWLIFTNLFLATL 1840
            .:.:|.::: |:.......:|...::.|:...|.|.:..:||....   |:.: .:.:.:.|..|
 Worm  2507 RNLTIEQIT-VVAYSSPTKQSKTTVYLEIGPFDVQPSLPKLLLHSK---PVQI-AVASLILLLFL 2566

  Fly  1841 LVVTIALCASQRNGYRRQLRAAKVNIFRGHSSMSLQDAQEPATRVPNTNK--HSVQ 1894
            |:|.|.:|..:.   ||:.:..|.   :.|..:.:...:.|:::.|...|  :||:
 Worm  2567 LIVVICICMCKS---RRKTQNEKE---KKHPDVIVTAERRPSSQKPTLQKQVYSVK 2616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637 22/126 (17%)
Cadherin_repeat 179..276 CDD:206637 23/96 (24%)
Cadherin_repeat 287..388 CDD:206637 25/102 (25%)
Cadherin_repeat 397..506 CDD:206637 32/193 (17%)
Cadherin_repeat 514..617 CDD:206637 23/102 (23%)
Cadherin_repeat 625..742 CDD:206637 33/116 (28%)
Cadherin_repeat 751..853 CDD:206637 29/143 (20%)
Cadherin_repeat 865..976 CDD:206637 30/193 (16%)
Cadherin_repeat 985..1080 CDD:206637 28/147 (19%)
Cadherin_repeat 1090..1191 CDD:206637 33/143 (23%)
CA 1221..1302 CDD:214520 25/172 (15%)
Cadherin_repeat 1312..1409 CDD:206637 31/97 (32%)
Cadherin_repeat 1418..>1502 CDD:206637 19/91 (21%)
Cadherin_repeat 1617..1710 CDD:206637 31/150 (21%)
cdh-1NP_497641.2 Cadherin_repeat 29..118 CDD:206637
Cadherin_repeat 129..229 CDD:206637 7/25 (28%)
Cadherin_repeat 238..328 CDD:206637 15/90 (17%)
Cadherin_repeat 459..532 CDD:206637 19/80 (24%)
Cadherin_repeat 546..637 CDD:206637 26/103 (25%)
Cadherin_repeat 645..733 CDD:206637 16/93 (17%)
Cadherin_repeat 746..833 CDD:206637 13/86 (15%)
Cadherin_repeat 843..938 CDD:206637 23/100 (23%)
Cadherin_repeat 947..1041 CDD:206637 33/115 (29%)
Cadherin_repeat 1051..1136 CDD:206637 23/93 (25%)
Cadherin_repeat 1337..1426 CDD:206637 12/88 (14%)
Cadherin_repeat 1445..>1515 CDD:206637 16/69 (23%)
Cadherin_repeat 1638..1723 CDD:206637 22/93 (24%)
Cadherin_repeat 1734..1817 CDD:206637 17/87 (20%)
Cadherin_repeat 1836..1923 CDD:206637 10/86 (12%)
Cadherin_repeat 1934..2025 CDD:206637 32/96 (33%)
Cadherin_repeat 2034..2120 CDD:206637 18/93 (19%)
Cadherin_repeat 2135..2226 CDD:206637 23/110 (21%)
Cadherin_repeat 2235..2330 CDD:206637 21/105 (20%)
Cadherin_repeat 2345..2437 CDD:206637 14/93 (15%)
Cadherin_repeat 2446..2534 CDD:206637 16/92 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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