DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cad88C and cdh-8

DIOPT Version :9

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:NP_001294412.1 Gene:cdh-8 / 184652 WormBaseID:WBGene00017576 Length:1684 Species:Caenorhabditis elegans


Alignment Length:1930 Identity:458/1930 - (23%)
Similarity:780/1930 - (40%) Gaps:442/1930 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 PDNDPLTFGKRNSHDSEIIRIENTGGNEAKIFLAKELDRELQDEYAIVLTLTDSHYSDHNYVTQS 157
            |.|..:..|...|:.: :::|..| .:..::.||.:.|:|..|                ....||
 Worm    50 PKNVKILSGDPASYFT-VVKINET-CSTLQLNLALDADKENAD----------------GLRGQS 96

  Fly   158 FLLLVE--------------DINDNVPTFLPYQNAIEIPEGSAPGV----VSTLEATDADEGAYG 204
            |.|::.              |:|||.|.|....::.||.|.:..|.    |:||   |.|.|..|
 Worm    97 FSLVIAGPKKSRATLEVQIVDVNDNSPQFSNTPSSFEISENAEIGTDIFKVTTL---DPDTGISG 158

  Fly   205 QVVYYLQELDGDNDVFSIATHQ---GK--GILRLQKELDYERKSLYQLRVLAID---RANQGPIN 261
            ...:   .::||:. |::|..:   ||  ..|||.|:||:|.|.::...:.|.|   .:|:    
 Worm   159 ISRF---SVEGDSS-FTLAKRKCSSGKCSTQLRLAKKLDFEEKPIHTFNITAKDGDPHSNR---- 215

  Fly   262 TGTAA--ILVKVKDLEDQPPEFV-EVQAVARIAEDAPVGTKVLRVRAIDGDRGINNPIAYSLEAN 323
            |.|.|  :.:.||:..|:||:|: :...|..|.:....|..:.::.|||.:.|..  |.:.::.|
 Worm   216 THTVAHTVTIHVKNENDEPPKFLTDFSQVFPIFKSTKPGDIIAKLEAIDVENGAE--IQFGMKEN 278

  Fly   324 DLFDINPHTGIVHTLTKLDREEQSDQVNGAHILRISATELSKSNT-QMAPTTVRTEVTVIVSDVN 387
            :...|:..:|.| .|.||..::....|.    |..::::..||.| :|....:..|.|:.....|
 Worm   279 EHLKIDSKSGNV-LLKKLPTDDALITVE----LYATSSKNGKSKTVEMKLRLMNDEATLPKIAEN 338

  Fly   388 DEIPTFGE-TVYRCEVNENAQT-NTPLNF-----IDEEVQNVVFDHDEGNNGTFRLFLDPPNDLF 445
            .|.|...| .:|...:.:...| :|||..     :.||...::     |.:.:|.|.:       
 Worm   339 QEKPELCEFPIYEAHLIQGTGTFSTPLKIKTLKSMAEEKPRLI-----GGSESFDLNV------- 391

  Fly   446 EIVPELAVNEANFMLRVKNSKSLDFEQFTEVNFTIFAREVDEPSRWSSAHVQIFIRDQNDN---- 506
                   :::.:..|:|.|::.:..:........:         :..|...:|.:|.....    
 Worm   392 -------IDDFHVELKVLNAEKVASQVLDSAQLLV---------KSQSGQCRIVLRSAAQMTPKA 440

  Fly   507 ---------FPEFSQTIYNASVLENSEQDTIITHVQAVDVDSGDY---GTMGIRYTNLRGGIAHL 559
                     .|:|.::.|...|:||.| .|::..|:.:......|   |..|.::.....|  .:
 Worm   441 SPIAQKLKIIPKFEKSEYQFQVVENRE-PTVLGEVKVISDGPVTYEILGENGEKFQISNDG--EI 502

  Fly   560 LNLNPITGVITIKQAGGTAFDREIISRHYLTVEAIDNAGQGNRNTAQIIVDILDVNDNAPTFPQR 624
            .||.||              |||...:..|.|:|.|..|...:  :|:|:.:.|.|||:|.|.:.
 Worm   503 QNLEPI--------------DRETYEKFELIVKATDLNGSSGK--SQLIIHVKDENDNSPIFDKE 551

  Fly   625 QYETKLLENQAEFETPLQLEARDADLNGTENSQVTYEIVEGLYRSNFTIDPQSGLLRPVHSFDFE 689
            .|...:.|.::|   .|::.|.|||  ..:|.|:.|.|.:.:......|.|...|.  :.:.|.|
 Worm   552 HYFITVDEGKSE---KLKITATDAD--SGKNGQIVYSIDQKIDNLPIDISPDGMLF--IGAIDRE 609

  Fly   690 ELVDGSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFYAKT 754
            .:  |:|             .|::|.|.|.|||.|..|....|.|.|:|:|||:|:|..|.|:..
 Worm   610 NM--GNS-------------NEVNLTVTASDSGEPKRSASATVTIRVKDINDNSPVFSNSRYSIP 659

  Fly   755 VPEDLPGGSSVLQVTAIDRDGSAPNNVVVYRIQTGAGDKFIINSETGVISVAHGANLDPDLTESK 819
            :..::..|..:.::.|.|.|.::|||.|.|   |....||.::....::....|       |..|
 Worm   660 LDANISPGGIIGRLEATDADSTSPNNYVTY---TSGDPKFTVSDSGEILFTGPG-------TLEK 714

  Fly   820 RSLYTLSVIALDGGLGNSQLMTTCTVNISIQDVN--NKPPVLKEMPALQILENTPVGTLVYRIQA 882
            .:....:|.|.|||                ..:|  |...|:.|..:::.:||    .|..:|.:
 Worm   715 SASLEFNVTAQDGG----------------DPMNSANALVVINEHRSMKSIEN----ELTTQINS 759

  Fly   883 TDL-DHKAILRYKLNPEHCEGRTEEGALVKSSEYDFLGA-----FEVDSIEGTLKVVKLLDRERV 941
            .|. ..|:.::: || ....|.|.|  ::::|...|..:     ..:||..|.:..:|.:|..||
 Worm   760 NDTGGEKSEIKW-LN-AGMPGYTYE--IIRASADGFSDSEVATWISIDSKSGRIYTLKKVDPSRV 820

  Fly   942 EHIKLAITVEDLAAAKGRQIAEGFLSIQVLDENDNNPKFRLPFYRQSITENSINGAMIVNVLASD 1006
            :.|||.|::.     ||::.....|.|.|:|.:|..|.:..|..:.|:||::..|..:|::....
 Worm   821 KQIKLHISMR-----KGKREVPVELIINVMDTDDVTPIYSTPTRKLSVTESATLGTTVVDMPVEG 880

  Fly  1007 VDKNRTITYALEGNPTYRSLMHLDPQTGEIVVASKIDHEQHQWLNFSVR--ATDSGIPARSSLVD 1069
            :.:...|.|:|:.....|..:.:| :.|.|.:...:|.|..|.:...|.  ...:|..|:||.: 
 Worm   881 IKEQNEIKYSLKITSGPRGKLQID-RYGTIKIIKSLDFETEQIIKGIVEGMVVKNGKAAKSSFI- 943

  Fly  1070 VYITVLDENDNNPYFVGGSKNYTIS--ENAAPGTRVATLQ---AGDADSGDFGKITFLMDRISSQ 1129
              :|:||.|||.|.| ..|.|:.:|  |::..|| |..|.   |.|.||..|..:.:.|  ...:
 Worm   944 --LTILDANDNRPIF-KNSSNFAVSLLESSVLGT-VLDLPYPLATDRDSSKFSTLKYSM--TGDE 1002

  Fly  1130 GKFTIDADTGVLTVADRLDRESKDSYNLVIEAWDNYQFGFLAGESRNAFKQVF----ISILDEND 1190
            |.|.||.....:.:...||.|::..::|.|:..||        :.|....:||    ::::|.||
 Worm  1003 GYFKIDESNSTIRLVAPLDFETQRVHSLSIKCVDN--------QGREPHHEVFASVTVTVIDVND 1059

  Fly  1191 NPPEV-DLPMSCVLITEYHELHERVASIVGKDADDPTTPNGRLDFAITRGNKDGMFELRQIDAWN 1254
            |.|.: :..::.:.|.|..::.:.|..:|..|:|:.......:|...|....|.          :
 Worm  1060 NAPVIHNTDLTHLSIEEDAQVGQVVTVLVISDSDEGGVQKTEIDVNSTLFRADS----------D 1114

  Fly  1255 AQIFASKSLRNRYG-NYSLTITTRDM-GLPANIVHNTLDICVSDF----NDHAPVFVRPLHNTTV 1313
            .::....||:...| ....|:|..|: ||.|     |...||:.:    ..|.|:.:.|..|:..
 Worm  1115 KKLVVIASLKGHAGQRICSTVTATDVGGLRA-----TSPYCVTVYPAKNTHHNPLVITPKQNSIH 1174

  Fly  1314 RIPENATVGTLI-LQAYASDGDMGQNALVRYRLKPDPLGSYKMFEVDGSTGELFLKEQLNREKQK 1377
            ...||.....|: ::....|||:|.   |.:||.......::||.:....|.|..::..:.||:.
 Worm  1175 YFDENIVYDELLKVKVLEEDGDIGN---VTFRLDEMFKKDWQMFTIGEINGSLHARQAFDFEKKT 1236

  Fly  1378 IHEIRIEAYDQGLPTSLSSDLDLTIYVRNVNDYEPQFMVNEISVNFTEHSDPGSERI-KLPDTID 1441
            :|||:|.|......||    ..|.|.|.:.||..|.|...::.:...| ::.|..:: ::|..:|
 Worm  1237 VHEIKILACRINNCTS----THLFISVNDRNDNCPMFPKQDVRLTVLE-NEKGKRQVGRIPAALD 1296

  Fly  1442 KDQLELDDPNDTPSQVCYFIVNGNEAGYFRLDPETHILTVDRELDREVIANFTLYVRATENCRND 1506
            .| ...|:     ::|||   ..:...:|..||...||..:...|||                  
 Worm  1297 SD-FHSDN-----TKVCY---TTDTPLFFFSDPTLPILFTNSSFDRE------------------ 1334

  Fly  1507 SISGGEKRRRMGIEINNRLGGIVHNQQFGYDRFKHSRQLRSTESNEYGPEDAELLSYEAYDS--S 1569
                                              |.:|              ..:|..|||.  |
 Worm  1335 ----------------------------------HKKQ--------------HQISITAYDCHLS 1351

  Fly  1570 QEDPTGGLATTHPELDSTVIKVKVRVLDINDNPPRFRSKIFT-----GGITTNADFGLKFMRVEA 1629
            ..||       |..::.|::.: :.|||||||.|:|..||:|     |.:||    |...:.|:|
 Worm  1352 CRDP-------HKPINGTIVAL-IDVLDINDNFPKFSEKIYTSTVVQGHVTT----GSHILTVQA 1404

  Fly  1630 TDADEGDNGRIGYYQVGEIRQTLSEGLENVRKAPFLLDQETGEVQLNFDPQKGMK-GYFDFVVLA 1693
            ||.||...| :.|...|.:|......:  ..::|..:|:.|||:...    :.:| ..:.|.|:.
 Worm  1405 TDLDEEPEG-LKYSIRGFVRSPSHSFV--AAESPISIDKSTGELSAT----EILKDSSYSFTVVV 1462

  Fly  1694 NDTSGMKDVAHVFIYLLREDQKVRFVFRL------QPDELRSRVDSFRDTLSNITESIVNIDEIK 1752
            .|.:|.:|.|.|.:..|..:......|::      |..||          :.:....::..:|.|
 Worm  1463 TDGAGHEDTASVVVIDLSYELSTNASFQISVVTYAQQTEL----------VFDAPFELIMKNEKK 1517

  Fly  1753 VHENKDGS------VDKTKTDLYMHLVEREDNSIYEVSEVLKLIDSHIESLNGLF----KELNVL 1807
            :.||...:      |||.:.:               .:..|.|:  |...:||.|    :.:|:|
 Worm  1518 IAENLSNATGLQTIVDKCRQN---------------ANFTLMLV--HFMDINGQFVNVDRAVNLL 1565

  Fly  1808 DTQAAEAQLLTAG-------------PSRGPLFVWLIFTNLFLATLLVVTIALCASQRNGYRRQL 1859
            .:.:||::.....             ||:.|.:: ||...||. .:.::::.:...|||.|.|:|
 Worm  1566 MSSSAESRRELRSVYGLREAFPPVPIPSKVPQYI-LIAVLLFF-VISILSMCIWCRQRNNYERKL 1628

  Fly  1860 RAAKVNIFRGHSSMSLQDAQEPATRVPNTNKHSVQGSNPIWLKGY 1904
            |         |.|     ||..........:...|..||    ||
 Worm  1629 R---------HIS-----AQASTVHTVTLGRGGKQTCNP----GY 1655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637 17/88 (19%)
Cadherin_repeat 179..276 CDD:206637 33/110 (30%)
Cadherin_repeat 287..388 CDD:206637 23/101 (23%)
Cadherin_repeat 397..506 CDD:206637 16/114 (14%)
Cadherin_repeat 514..617 CDD:206637 27/105 (26%)
Cadherin_repeat 625..742 CDD:206637 33/116 (28%)
Cadherin_repeat 751..853 CDD:206637 21/101 (21%)
Cadherin_repeat 865..976 CDD:206637 30/116 (26%)
Cadherin_repeat 985..1080 CDD:206637 24/96 (25%)
Cadherin_repeat 1090..1191 CDD:206637 29/109 (27%)
CA 1221..1302 CDD:214520 18/86 (21%)
Cadherin_repeat 1312..1409 CDD:206637 26/97 (27%)
Cadherin_repeat 1418..>1502 CDD:206637 17/84 (20%)
Cadherin_repeat 1617..1710 CDD:206637 24/93 (26%)
cdh-8NP_001294412.1 Cadherin_repeat <55..121 CDD:206637 15/83 (18%)
Cadherin_repeat 131..232 CDD:206637 33/111 (30%)
Cadherin_repeat 457..544 CDD:206637 27/105 (26%)
Cadherin_repeat 552..647 CDD:206637 33/116 (28%)
Cadherin_repeat 656..741 CDD:206637 24/110 (22%)
Cadherin_repeat 861..952 CDD:206637 24/94 (26%)
Cadherin_repeat 964..1060 CDD:206637 28/106 (26%)
Cadherin_repeat 1184..1265 CDD:206637 25/87 (29%)
Cadherin_repeat 1275..1375 CDD:206637 33/183 (18%)
Cadherin_repeat 1396..1476 CDD:206637 24/86 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H71045
Inparanoid 1 1.050 319 1.000 Inparanoid score I1505
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46529
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007436
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_112779
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X13589
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.870

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