DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cad88C and cdh-3

DIOPT Version :9

Sequence 1:NP_731930.3 Gene:Cad88C / 41774 FlyBaseID:FBgn0038247 Length:1981 Species:Drosophila melanogaster
Sequence 2:NP_498687.2 Gene:cdh-3 / 176085 WormBaseID:WBGene00000395 Length:3361 Species:Caenorhabditis elegans


Alignment Length:2478 Identity:495/2478 - (19%)
Similarity:841/2478 - (33%) Gaps:928/2478 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 ISIQVIILTTLISLVASNRPPRFAIDGQSEIVLRLKESPETKVGTLIYTLK---GYDPDNDPLTF 100
            |...:.:|..||.....|...:|     ||..::...|.:.|:.|:|..|:   ||       |:
 Worm     5 IFFSIFLLNHLIFFHLFNFTHQF-----SEETIKFSVSEDAKLNTIIGHLEAEIGY-------TY 57

  Fly   101 GKRNSHDSEIIRIENTGGNEAKIFLAKELDRELQDEYAI-VLTLTDSHYSDHNYVTQSFLLLVED 164
              |.|..:..|:.:.   ...::.::..||||  .|.|| :|.:|......|      .|:.|.|
 Worm    58 --RLSRGNSKIKFDE---QTLELSVSSPLDRE--SENAIDMLIITSPPSIIH------ILIDVLD 109

  Fly   165 INDNVPTFLPYQNAIEIPEGSAPG-VVSTLEATDADEGAYGQVVYY-----LQELDGDNDVFSIA 223
            :|||.|.|......:||||.:..| .|....|||.|||..|.:..|     |..:| ....|.|.
 Worm   110 VNDNSPIFPIDVQRVEIPETAPIGWRVQISGATDPDEGKNGTIGKYELVDSLATVD-TMSPFGIV 173

  Fly   224 THQGKGILRLQKELDYERKSLYQLRVLAIDRANQG-PINTGTAAILVKVKDLEDQPPEFVEVQAV 287
            ...|...|.:..:||.|.:.||.:|:.|||   || |..:.:..:.:.:.|:.|.||.|      
 Worm   174 QSDGFLFLEVTGKLDRETRDLYSMRLTAID---QGVPELSSSCHLNILILDINDNPPNF------ 229

  Fly   288 ARIAEDAPVGTKVLRVRAIDGDRGINNPIAYSLEANDLFDINPHTGIVHTLTKLDREEQSDQVNG 352
                     |.:.|.:..    .|:.|...:||.|.|| |.|.::.:.:.:.......:...::.
 Worm   230 ---------GIRSLTLNW----NGLPNTKLFSLNATDL-DSNENSLLTYRILPSGPTSEMFSISD 280

  Fly   353 AHILRISATELSKSNTQMAPTTVRTEVTVIVSDVNDEIPTFGET---VYRCEVNENAQTNTPLNF 414
            .:||      ::::||:...   |.|..|...|  ..:|....|   |...|.....:.|..:.|
 Worm   281 ENIL------VTQNNTECLQ---RCEFVVEARD--SGVPPLSTTLNIVVNMEYGNEHEPNINIRF 334

  Fly   415 IDEEVQNVVFDHDEGNNGTFRLFLDPPND------------------LFEIVPELAVNEANFMLR 461
            ...:...::...::.|..|..:.....:|                  :|.::...::|    :|.
 Worm   335 YPSDYPFIIVQPEDVNGKTLAILSITDSDGPLGANSTIWIENGNEQSIFSLISRQSIN----ILT 395

  Fly   462 VKNSKSLDFEQFTEVNFTIFAREVDEPS-RWSSAHVQIFIRDQNDNFPEFSQTIYNASVLENSEQ 525
            ||:.::.:.||:. :.|.  |.:...|: |.:...::||.:    .:.:.:|...........|:
 Worm   396 VKHVENANQEQYI-LEFR--ANDGQSPADRITRKELKIFFK----KYVKSTQIHVERESHVTVEK 453

  Fly   526 DTI----ITHVQA-----------------VDVDSGDYGTMGIRYTNLRGGIA--HL---LNLNP 564
            ||:    :.||:.                 :|..:|...|..|    |..|:.  ||   ::|.|
 Worm   454 DTVPGSFVAHVETNCTDMCSFELANSDVFKIDPFNGIIVTSSI----LPEGVTSYHLPIRIHLPP 514

  Fly   565 IT--------------------------GVITIKQAG----------GTAFDREIISRHYLTVEA 593
            .:                          ..|.:|:|.          ||...|...::.|.|::.
 Worm   515 PSTQLVEADVFVKVIQESVPKNLIRSSESPIHLKRAYTFTTWQDVSLGTVIGRLPKAQIYSTIDT 579

  Fly   594 IDNAG---QG--------------------NRNTAQ---IIVDILDVNDNAPTFPQRQYETKLLE 632
            :...|   .|                    ||||.|   |.:.:..:|.::|..  :..|..:||
 Worm   580 VSELGVFPDGSVFVGKTITSDFVTLPVTLVNRNTTQTSIITLIVKPLNQHSPIC--QITEIHVLE 642

  Fly   633 NQAEFETPL-----QLEARDAD--LNGTENSQVTYEIV--EGLYRSNFTIDPQSGLLRPVHSFDF 688
            |     .|:     :::|||.|  |:|.    |:|:|:  ...|...|.:|..||.||.:.:||.
 Worm   643 N-----APIGTIFGRIQARDEDSGLSGV----VSYKILTKSDDYDGIFHLDSTSGSLRSLKAFDA 698

  Fly   689 EELVDGSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYVQDVNDNAPIFQQSFYAK 753
            |:      :||  ||          ....|:|.|.|..:|..|..|:::|||||.|.|...:|..
 Worm   699 EK------KRS--YT----------FEYEAKDLGTPSKTTNCPATIFIEDVNDNVPKFGSRYYTA 745

  Fly   754 TVPEDLPGGSS---VLQVTAIDRDGSAPNNVVVYRIQTGAGDKFIINSETGVISVAHGANLDPDL 815
            |:     .|.|   |..|.|.|.|....|..:.|.: ....|.|.::.|||.::...    |..:
 Worm   746 TI-----SGKSNETVAIVQANDNDVDVKNQKLQYHL-LNYHDFFQLDKETGKVTTIQ----DVPM 800

  Fly   816 TESKRSLYTLSVIALDGG---LGNSQLMTTCTVN--ISIQDVNNKPPVLKEMPALQILENTPVGT 875
            |..:.:: ::|.:.:|..   ...:.|:.|.|.:  :::|        |.....::|.:|..:|.
 Worm   801 TWQRLNI-SISAVNMDSERFLQSKTFLLVTVTSSSKLAVQ--------LNSGNLIRIFKNDKIGE 856

  Fly   876 LVYRIQATDLDHKAILRYKLNPE-HCEGR-----TEEGALVKSSEYDFLGAFEVDSIEGTLKV-- 932
            .|..:...  ..:.:....|:|. |.:..     ....|...|:.:|.:  ...::.|.|.||  
 Worm   857 KVGHLDIA--SSETVYWSTLDPRLHVDSSGNIILIRRNAKQASTGFDII--LTSENGEKTEKVNF 917

  Fly   933 -VKLLDRERVEHIKLAITVEDLAAAKGRQIAEGFLS-------IQVLDENDNNP---KFRLPFYR 986
             |:.:|.||.|.::   .|.|:...:........::       .:|:.||.||.   .|.|...:
 Worm   918 EVEFVDSERSEDVE---KVMDIVLNENTTEVSNLMNDWKNWKISRVILENANNSGNNTFFLEHKK 979

  Fly   987 QSITEN-SINGAMIVNVLASDVDKNRTITYALEGNPTYRSLMHL--------------------D 1030
            ...|:| :::.|.|  :|.|: |:        ||:|....|:|:                    .
 Worm   980 LWRTKNATVSNAYI--ILESE-DQ--------EGSPKSFKLLHVTTSPSPSSESSCISPAHLISP 1033

  Fly  1031 PQTGEIVVASKIDHEQHQWLNFSVRATDSG--IPARSSLVD-VYITVLDENDNNPYFVGGSKNYT 1092
            |.|  :.:.|...:.:.|.|..|::..::.  ||.:|.|:: |.:.....:|..|:.:...|:| 
 Worm  1034 PST--VPLPSNCSNVKLQNLKTSLQIHENNLLIPTQSELINHVDLVSTQNSDMKPFMMTLIKDY- 1095

  Fly  1093 ISEN--------------------------AAPGTRVATLQAG------DADSGDF--------- 1116
            :||:                          |..|.|:.....|      |||:|:.         
 Worm  1096 LSEDVRFSTNNVLMLLSSIHPIGTSFGRVTAESGYRIRYYIVGTDKISIDADTGELILKERFYRN 1160

  Fly  1117 ----------------GKITF--LMDRI------------------SSQGKFTIDADTGVLTVAD 1145
                            .|||.  :.||:                  |..||..||.|...:.|.|
 Worm  1161 LNDILIVAVIPKGIAKAKITIEVIEDRLILPQSNFFIPSPPSFNSKSKIGKIPIDRDDVTIDVID 1225

  Fly  1146 R-----------------------------------------------LDRESKDSYNLVIEAWD 1163
            .                                               ..||.::: .|:.|..:
 Worm  1226 EHFYVRNFEIFVKRHFIPNSNFYDLKGTVKKGKLSAPISVTLFFGEKMKSREIREN-ELMFEIEE 1289

  Fly  1164 NYQFGFLAG-----------------------------------------------ESRNAFKQV 1181
            |...|.:.|                                               .|.|....:
 Worm  1290 NSPIGTVVGVVPNSDTTKYRLVDPTCGLLIDQEGIIRTTTVFDRENTSLLKTKMIEPSENRIWNL 1354

  Fly  1182 FISILDENDNPPEV-DLPMSCVLITEYHELHERVA-------------SIVGKDA---------- 1222
            .|.|.|.|||.|:: :.|...::   |.:|:.::.             |||..|.          
 Worm  1355 LIFIADVNDNKPKILNAPGRIIV---YDDLNYKLEWEDLDAIASDVSFSIVDGDVFGNLEIEDSG 1416

  Fly  1223 -----------------------------DDPTTPNGRLDFAITR----------------GNKD 1242
                                         ||.|     ::|.:|:                ||:|
 Worm  1417 VISLNSIPNESFNATIRIYDNRPPFKVHFDDVT-----IEFQVTQKLRAVTCEDAEFWMFFGNED 1476

  Fly  1243 -GMFELRQIDAW--------------------------------------------------NAQ 1256
             ||....:|..|                                                  :.:
 Worm  1477 VGMLIASEIVTWRIVPQIGSDSFKIDPITGIIQSTPNTKPTSDIAKLKIQAISYDGERVGFCDVK 1541

  Fly  1257 IFASKS-----------------------------------------LRNRYGNYSLTITTRDMG 1280
            |...|:                                         .|.:..:|:.||:..|..
 Worm  1542 IHIDKAAFVENVVLSNGTFEFNISETADRFTEVGKIVILGAGLEGSVFRIQDNDYNFTISPFDGT 1606

  Fly  1281 LPAN------------------------IVHNTLDICVSDFNDHAPVFVR-PLHNTTVRIPENAT 1320
            :..|                        |:|      |:|.||.||.|:. .:.|..| :.|..|
 Worm  1607 IFTNSPLDFENIKTYRFNITAGKSTSQVIIH------VTDENDEAPRFITGDVVNLKV-LEELDT 1664

  Fly  1321 VG--TLILQAYASDGDMGQNALVRYRLKPDPLGSYKMFEVDGSTGELFLKEQLNREKQKIHEIRI 1383
            |.  .:|..:.|.|.|.|||.||.|.:..   |:..:|.|:.:||::.....|:||:..:||:.|
 Worm  1665 VSYPLIIGSSIAEDLDEGQNGLVTYSILS---GNTSLFAVNSTTGDILSLIPLDREESSLHELLI 1726

  Fly  1384 EAYDQGLPTSLSSDLDLTIYVRNVNDYEPQFMVNEISVNFTEHSDPGSERIKLPDTIDKDQ---- 1444
            ||.|.|:| |||:...:.|:|.::||..|:|.::...:..:|:|..||:.|::..| |||:    
 Worm  1727 EAKDAGIP-SLSATSKILIHVGDINDNTPEFELSSYFIKISENSKIGSKIIRILAT-DKDKDAEL 1789

  Fly  1445 ---LELDDPNDTPSQVCYFIVNGNEAGYFRLDPETHILTVDRELDREVIANFTLYVRATENCRND 1506
               ||.:|....|               ||::..|..:||..:::||....|..:|:.|:     
 Worm  1790 QYSLESNDEITIP---------------FRINVATGWITVAGKVNREENEEFRFFVKVTD----- 1834

  Fly  1507 SISGGEKRRRMGIE------------INNRLGGI----------------VHNQQFGYDRFKHSR 1543
                |||..::.:|            ||:|...|                ||:    .|:..|.:
 Worm  1835 ----GEKSSKVIVEIHVEDFNDNHPMINDRNSDIFVPDPTRSVEIIHVINVHD----LDKSDHLK 1891

  Fly  1544 --------------------------QLRSTESNEYG---------------------------- 1554
                                      .:|.|.|::.|                            
 Worm  1892 FSLNNSNLNLSENGEITLKSPLQTAVPVRVTVSDDAGHVAFMEYLFHPHSRKHFPVFVEKLDTVS 1956

  Fly  1555 ---PEDAELLSYEA-------------YDSSQEDPTGGLATTHPELD------------------ 1585
               .::.||..::|             .|..:.:.:.|:..|...||                  
 Worm  1957 VREHDEQELAVFKANGDSIRYSIVSRCSDHLEMEKSTGILKTKSSLDAEEYSECLVFIIATTYFD 2021

  Fly  1586 ----STVIKVKVRVLDINDNPPRFRSKIFTGGITTNADFGLKFM-RVEATDADEGDNGRIGYYQV 1645
                ||:.|..::::|||||.|||..:::...:|.|:  |.|.: .|.|.|.|.  :.|:.|..|
 Worm  2022 NKPLSTITKATIKIVDINDNSPRFDQQLYRFNVTENS--GPKLIGHVIARDIDR--SSRVFYEIV 2082

  Fly  1646 G-----EIRQTLSEGLENVRKAPFLLDQETGEVQLNFDPQKGMKGYFDFVVLANDTSGMKDVAH- 1704
            |     |...|.|..:|:||.    ||:||             |..:..:|.|.|....:...: 
 Worm  2083 GGDANHEFMVTESGQIESVRD----LDRET-------------KSEYHLIVEAIDDGKPRRRGNT 2130

  Fly  1705 -VFIYLLREDQKV-RF--VFRLQ-PDELRSRVDSFRDTLSNITESIVNIDEIKVHENKDGSVDKT 1764
             |.:.:|.||... ||  :|.:: |:::|            |.|.::.:......|:        
 Worm  2131 TVIVTVLDEDDNAPRFSRIFHVEVPEDVR------------IGEPVIQLSASDADEH-------- 2175

  Fly  1765 KTDLYMHLVEREDNSIYEVSEVLKLIDSHIESLNGLFKELNVLDTQAAEAQLLTAGPSRGPLFVW 1829
                        .|..:|:....:.|...::...|:....:.||.:..::..:....:.|   .|
 Worm  2176 ------------SNHRFELDGGGEGIPFRVDENTGMVFVNDSLDFEKKQSYRIKVKLTDG---AW 2225

  Fly  1830 LIFTNLFL 1837
            ||.|:||:
 Worm  2226 LIETSLFV 2233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cad88CNP_731930.3 Cadherin_repeat 76..168 CDD:206637 25/95 (26%)
Cadherin_repeat 179..276 CDD:206637 33/103 (32%)
Cadherin_repeat 287..388 CDD:206637 19/100 (19%)
Cadherin_repeat 397..506 CDD:206637 20/127 (16%)
Cadherin_repeat 514..617 CDD:206637 32/190 (17%)
Cadherin_repeat 625..742 CDD:206637 38/125 (30%)
Cadherin_repeat 751..853 CDD:206637 24/109 (22%)
Cadherin_repeat 865..976 CDD:206637 24/126 (19%)
Cadherin_repeat 985..1080 CDD:206637 23/118 (19%)
Cadherin_repeat 1090..1191 CDD:206637 37/271 (14%)
CA 1221..1302 CDD:214520 27/251 (11%)
Cadherin_repeat 1312..1409 CDD:206637 35/98 (36%)
Cadherin_repeat 1418..>1502 CDD:206637 23/90 (26%)
Cadherin_repeat 1617..1710 CDD:206637 26/100 (26%)
cdh-3NP_498687.2 Cadherin_repeat 31..113 CDD:206637 25/101 (25%)
Cadherin_repeat 121..225 CDD:206637 33/107 (31%)
Cadherin_repeat 242..326 CDD:206637 20/95 (21%)
Cadherin_repeat 448..529 CDD:206637 15/84 (18%)
Cadherin_repeat 637..734 CDD:206637 38/123 (31%)
Cadherin_repeat 743..831 CDD:206637 22/98 (22%)
Cadherin_repeat 1116..1184 CDD:206637 11/67 (16%)
Cadherin_repeat 1285..1364 CDD:206637 10/78 (13%)
Cadherin_repeat 1559..1643 CDD:206637 10/89 (11%)
Cadherin_repeat 1671..1752 CDD:206637 32/84 (38%)
Cadherin_repeat 1760..1853 CDD:206637 27/117 (23%)
CA 1975..2043 CDD:214520 13/67 (19%)
Cadherin_repeat 2050..2142 CDD:206637 30/112 (27%)
Cadherin_repeat 2149..2241 CDD:206637 19/120 (16%)
Cadherin_repeat 2250..2329 CDD:206637
LamG 3082..3201 CDD:214598
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I7543
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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