DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cad88C and Cdhr1

DIOPT Version :9

Sequence 1:	NP_731930.3	Gene:	Cad88C / 41774	FlyBaseID:	FBgn0038247	Length:	1981	Species:	Drosophila melanogaster
Sequence 2:	NP_570948.1	Gene:	Cdhr1 / 170677	MGIID:	2157782	Length:	859	Species:	Mus musculus

Alignment Length:	909	Identity:	262/909 - (28%)
Similarity:	412/909 - (45%)	Gaps:	132/909 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ISLVASNRPPRFAID--GQSEIVLRLKESPE-TKVGTLIYTLKGYDPDNDPLTFGKRNSHDSEII 111
            |.|..:|..|.|..:  |.:...:.|...|| |.||:.:|||.|.||:.||:::  ..|.|....
Mouse    16 IYLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPEGDPISY--HISFDPSTR 78

  Fly   112 RIENTGGNEAKIFLAKELDRELQDEYAIVLTLTDSHYSDHNYVTQSFLLLVEDINDNVPTFLPYQ 176
            .:.:...|...|.|.:|||||.:||...:::::|.    .|.|.:..::||.|.||..|.|:...
Mouse    79 SVFSVDPNFGNITLVEELDREREDEIEAIISISDG----LNLVAEKVVILVTDANDEAPRFIQEP 139

  Fly   177 NAIEIPEGSAPG-VVSTLEATDADEGAYGQVVYYLQELDGDNDVFSIATHQGKGILRLQ--KELD 238
            ..|.:||....| .:..::|.|.|.|:.|.|.|.||.|....  ||:..|  .|:||||  ..||
Mouse   140 YIIRVPENIPAGSSIFKVQAEDKDTGSGGSVTYSLQNLHSSK--FSMDRH--SGVLRLQAGATLD 200

  Fly   239 YERKSLYQLRVLAIDRANQ----GPINTGTAAILVKVKDLEDQPPEFVEVQAVARIAEDAPVGTK 299
            ||:...:.:.|:|.|...:    ..:.:.|..:.:.|:|::|..|.||.......:.||...|::
Mouse   201 YEKSRAHYITVIAKDGGGRLRGADMVFSATTTVTINVEDVQDTAPIFVGTPYYGYVYEDTLPGSE 265

  Fly   300 VLRVRAIDGDRGINNPIAYSL--EANDLFDINPHTGIVHTLTK---LDREEQSDQVNGAHILRIS 359
            ||.|.|||||||..|.|.|.|  |::.:|:||..:|.:..|..   |.||        .:.|.:.
Mouse   266 VLTVVAIDGDRGKPNHILYRLLNESDGIFEINETSGAISVLQSPALLRRE--------VYELHVQ 322

  Fly   360 ATELSKSNTQMAPTTVRTEVTVIVSDVNDEIPTF-GETVYRCEVNENAQTNTPLNFIDEEVQNVV 423
            .||::...:..|..||  .||:.:.|:|:..||| ||:..:.:...:...:.|...|...::..|
Mouse   323 VTEVNSPGSPAAQATV--PVTIRIVDLNNHPPTFYGESGPQNKFELSMFEHPPQGEILRGLKITV 385

  Fly   424 FDHDEGNNGTFRLFLDPPNDLFEIVPELAVNEANFMLRVKNSKSLDFEQFTEVNFTIFAREVDEP 488
            .|.|:|.|..|.|.|..|..:|.:||:..:|||...:.|:||.::|||:...:.|.:.|.||:.|
Mouse   386 NDSDQGANAKFNLRLVGPGGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKLLTFKLLAIEVNTP 450

  Fly   489 SRWSS-AHVQIFIRDQNDNFPEFSQTIYNASVLENSEQDTIITHVQAVDVDSGDYGTMGIRYTNL 552
            .::|| |.:.|.:.|.|||.|:|:...|.|.:.||:...:.:..|.|||.|:|.:|.:   :.::
Mouse   451 EKFSSTADIVIQLLDTNDNVPKFTSHYYIARIPENAPGGSNVVAVTAVDPDTGPWGKV---HYSI 512

  Fly   553 RGGIAHLLNLNPITGVITIKQAGGTAFDREIISRHYLTVEAIDNAGQGNRNTAQIIVDILDVNDN 617
            .|..:.|..::|.||:|..:.  ..:.|.|..||:...|:|.|.  .|..:.|::.|.:|||||:
Mouse   513 YGTGSDLFLIHPSTGLIYTQP--WASLDAEGTSRYNFYVKAEDM--DGRYSLAEVFVTLLDVNDH 573

  Fly   618 APTFPQRQYETKLLENQAEFETPLQLEARDADLNGTENSQVTYEIVEGLYRSNFTIDPQSGLLRP 682
            .|.|.|...|..::     ..|||::||.|.|.. ..|:.|.|.|......:.|.||..:|.:|.
Mouse   574 YPQFVQSVQEKTMV-----LGTPLKIEATDQDAE-EPNNLVDYSITRAEPVNVFDIDAHTGEIRL 632

  Fly   683 VHSFDFEELVDGSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYVQDVNDNAPIFQ 747
            .:|....|.:...:...| |   |:|::     |:|:|.|.|..||...:.|   |:.|...:.:
Mouse   633 KNSIRSLEALHNITPSGD-Y---SWSLQ-----VQAKDRGSPSFSTTALLKI---DITDTERLSR 685

  Fly   748 QSFYA-----KTVPEDLPG--------------------------GSSVLQVTAI--DRDGSAPN 779
            .|..|     |..|....|                          .:.||.|..:  .|...||:
Mouse   686 GSMAAFLIQTKDNPMKAVGVLAGVMAIVVAITVLISTATFWRNKKSNKVLPVRRVLRRRPSPAPH 750

  Fly   780 NVVV----YRIQTGAGDKFII----------NSETGVISVAHGANLDPDLTESKRSLYTLSVIAL 830
            .|.:    :| :..|..|||:          ||..||:.......|.|....:...:...:|..:
Mouse   751 TVRIEWLKFR-RAKAATKFILKEDSPNENCNNSRVGVMVPPRAPALPPPPKMASSMVAQQTVPTV 814

  Fly   831 DGGL---GNSQLMTTCTVNISIQDVNNKPPVLKEMPALQILENTPVGTLVYRIQATDLDHKAIL 891
            .|.|   .:.||.|..|:...:|                   ::.|..|..:.:...||:||.:
Mouse   815 SGSLTPQPSPQLPTPKTLGGPVQ-------------------SSLVSELKQKFEKKSLDNKAYI 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cad88C	NP_731930.3	Cadherin_repeat	76..168	CDD:206637	32/92 (35%)
		Cadherin_repeat	179..276	CDD:206637	32/103 (31%)
		Cadherin_repeat	287..388	CDD:206637	35/105 (33%)
		Cadherin_repeat	397..506	CDD:206637	34/109 (31%)
		Cadherin_repeat	514..617	CDD:206637	31/102 (30%)
		Cadherin_repeat	625..742	CDD:206637	32/116 (28%)
		Cadherin_repeat	751..853	CDD:206637	30/151 (20%)
		Cadherin_repeat	865..976	CDD:206637	6/27 (22%)
		Cadherin_repeat	985..1080	CDD:206637
		Cadherin_repeat	1090..1191	CDD:206637
		CA	1221..1302	CDD:214520
		Cadherin_repeat	1312..1409	CDD:206637
		Cadherin_repeat	1418..>1502	CDD:206637
		Cadherin_repeat	1617..1710	CDD:206637
Cdhr1	NP_570948.1	Cadherin_repeat	42..130	CDD:206637	31/93 (33%)
		Cadherin_repeat	139..242	CDD:206637	32/106 (30%)
		Cadherin_repeat	251..350	CDD:206637	36/108 (33%)
		Cadherin_repeat	364..469	CDD:206637	34/104 (33%)
		Cadherin_repeat	478..573	CDD:206637	31/101 (31%)
		Cadherin_repeat	580..679	CDD:206637	32/116 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..838		10/63 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9126
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24028
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010