back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cad88C and fat4

DIOPT Version :10

Sequence 1:	NP_731930.3	Gene:	Cad88C / 41774	FlyBaseID:	FBgn0038247	Length:	1981	Species:	Drosophila melanogaster
Sequence 2:	XP_004911174.2	Gene:	fat4 / 100145590	XenbaseID:	XB-GENE-981052	Length:	4962	Species:	Xenopus tropicalis

Alignment Length:	2065	Identity:	548/2065 - (26%)
Similarity:	862/2065 - (41%)	Gaps:	422/2065 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 DNDP--------LTFGKRNSHDSEIIRIE-------NTG--------GNEAKIF----------L 125
            ||.|        .:..:..|:.::::|:.       |.|        |||.|.|          |
Frog  1192 DNHPKFSKDLYQASISELASNMTQVLRVSSSDVDEGNNGLISYSIMKGNEEKHFTMDSSTGQVAL 1256

  Fly   126 AKELDRELQDEYAIVLTLTDSHYSDHNYVTQSFLLLVEDINDNVPTFLPYQNAIEIPEGSAPG-V 189
            ...||.|....|::::...||.....: .|.:..:.|.|.|||.|:|......:::.|....| :
Frog  1257 VGRLDYEATASYSLIIQAVDSGAVPLS-ATSTLSIEVLDENDNSPSFPKAALFVDVVENMRVGEL 1320

  Fly   190 VSTLEATDADEGAYGQVVYYLQELDGDND--VFSIATHQGKGILRLQKELDYERKSLYQLRVLAI 252
            ||::.|||:|.|....:.|   .:.|.|:  .|||:.:.|.  :.|.|:||:|.::||:|.:.|.
Frog  1321 VSSVTATDSDSGDNADIHY---SITGTNNHGTFSISPNTGS--IFLAKKLDFETQALYKLNITAK 1380

  Fly   253 DRANQGPINTGTAAILVKVKDLEDQPPEFVEVQAVARIAEDAPVGTKVLRVRAIDGDRGINNPIA 317
            |:.|  |..:.|.::::||:|..|.||.|........:.|:..:||.:|.|.|.|.|..||..:.
Frog  1381 DKGN--PPRSSTMSVIIKVRDFNDNPPSFPAGDIFKSVVENVLIGTSILTVTATDPDADINGQLT 1443

  Fly   318 YSL----EANDLFDINPHTGIVHTLTKLDREEQSDQVNGAHI--LRISATELSKSNTQMAPTTVR 376
            |::    ...:.|.|:...|.::|..::|||       .|::  |.:.|::|:      .|...|
Frog  1444 YTIIQQKPRGNHFVIDEVRGTIYTNAEIDRE-------FANLFELTVRASDLA------VPLESR 1495

  Fly   377 ----TEVTVIVSDVNDEIPTFGETVYRCEVNENAQTNTPLNFIDEEVQNV-VFDHDEGNNGTFRL 436
                ..||:::||:||.:|||        |::||....|...|...:..: .||.|||:||...
Frog  1496 KYALKNVTILISDLNDNVPTF--------VSQNAFAADPSLAIGSVLSTITAFDPDEGSNGEIE- 1551

  Fly   437 FLDPPNDLFEIVPELAVNEANFMLRVKNSKSLDFEQFTEVNFT-------------------IFA 482
                    :||:                  |.|.|.|....::                   :.|
Frog  1552 --------YEII------------------SGDTETFIVDRYSGDLRVAAPMLPSHLIYSLIVAA 1590

  Fly   483 REVDEPSRWSSAHVQIFIRDQNDNFPEFSQTIYNASVLENSEQDTIITHVQAVDVDSGD----YG 543
            .::....:.::..:.|.:..|:.  |.|||..|...:.|.....|.:.:::|......|    |.
Frog  1591 TDLGAERKATTTELTIILEGQDG--PVFSQLKYITILKEGEPVGTNVINIEAASPRGTDSVVEYF 1653

  Fly   544 TMGIRYTNLRGGIAHLLNLNPITGVITIKQAGGTAFDREIISRHYLT-VEAID-NAGQGNRNTAQ 606
            .:.:|.....  :..|..:...||||..    ....|||..:|.||. |.||: .|.......||
Frog  1654 IVSVRCEGRT--VGRLFTIGRNTGVIQT----AAVLDRERGARLYLVDVYAIEKEASLPKTQRAQ 1712

  Fly   607 IIVDILDVNDNAPTFPQRQYETKLLENQAEFETPLQLEARDADLNGTENSQVTYEIVEGLYRSNF 671
            :.:.:.|:|||.|.||....:..:.||..:....:||.|.|||..  .|:.|||.|:.|. ..:|
Frog  1713 VEITLQDINDNPPVFPTDILDLTVEENVGDGSKIMQLTATDADEG--PNALVTYTIISGA-DDSF 1774

  Fly   672 TIDPQSGLLRPVHSFDFEELVDGSSRRSDPYTGGSFSIREIDLLVRARDSGIPMLSTVVPVLIYV 736
            .|||:||.|......|.|       |||           :..|||||.|.   :.|:.:.:.|.:
Frog  1775 RIDPESGDLIATKRLDRE-------RRS-----------KYSLLVRADDG---LQSSDMRINITI 1818

  Fly   737 QDVNDNAPIFQQSFYAKTVPEDLPGGSSVLQVTAIDRDGSAPNNVVVYRIQTGAGDK-FIINSET 800
            .||||:.|.|.::.|:..|.||...||.|..:.|.| |.|..|..:.|.:.....|. |.:|..|
Frog  1819 SDVNDHIPKFSRAVYSFDVAEDTIPGSIVAAILATD-DDSGVNGEITYAVSDDDDDGIFFLNPVT 1882

  Fly   801 GVISVAHGANLDPDLTESKRSLYTLSVIALDGGLGNSQLMTTCT-VNISIQDVNNKPPVL-KEMP 863
            ||.:|...  ||.:|    :..|.|:|.|.|||..:|     |. |..:|.|||:.|||. :...
Frog  1883 GVFNVTRA--LDYEL----QQYYVLTVCAQDGGGQDS-----CVRVYFNILDVNDNPPVFSRNSY 1936

  Fly   864 ALQILENTPVGTLVYRIQATDLD--HKAILRYKLNPEHCEGRTEEGALVKSSEYDFLGAFEVDSI 926
            :..::||.|.|:.:.....||.|  ..:.|.|.:                 |..|.:|.|:| |.
Frog  1937 SASVMENLPPGSTILTFNVTDADDGFNSKLSYTI-----------------SSGDSMGQFQV-SK 1983

  Fly   927 EGTLKVVKLLDRERVEHIKLAITVEDLAAAKG-RQIAEGFLSIQVLDENDNNPKFRLPFYRQSIT 990
            :|||.|::|||||......|.:.|.|:|.... |..:...:||.:||.|||.|.|..|.... :.
Frog  1984 DGTLSVLQLLDRETQSFYSLVVQVHDMAPPPAPRYTSSVEVSIILLDVNDNPPSFISPKLTY-VQ 2047

  Fly   991 ENSINGAMIVNVLASDVDK--NRTITYALEGNPTYR-SLMHLDPQTGEIVVASKIDHEQHQWLNF 1052
            ||:....::....|:|.|.  |..|.|:|.|:...: |:..:|   ||:.:..::|.|.......
Frog  2048 ENTPTDTVVFRAQATDPDSGPNSYIQYSLLGSLGNKFSIGIID---GEVRLTGELDREDISNYTL 2109

  Fly  1053 SVRATDSGIPARSSLVDVYITVLDENDNNPYFVGGSKNYTISENAAPGTRVATLQAGDADSGDFG 1117
            ::.|.|.|.|:.||.:|:.|.|||.|||:|:|........|||:...||.:..|.|.|||.|..|
Frog  2110 TIIAKDKGEPSLSSSMDMNIIVLDINDNSPHFSQRHFKVEISESTLTGTDLIQLIASDADEGING 2174

  Fly  1118 KITFLMDRISSQGKFTIDADTGVLTVADRLDRESKDSYNLVIEAWDNYQFGFLAGES-RNAFKQV 1181
            .:.:.:...:...:|.||:.||||::|..||||.|.||.|.|:|.|.       |.| |:....|
Frog  2175 MVRYAIIDGNPSNEFRIDSVTGVLSIARPLDRERKSSYTLKIQASDR-------GSSPRSDTATV 2232

  Fly  1182 FISILDENDNPPEVDLPMSCVLITEYHE-LHERVASIVGKDADDPTTPNGRLDFAITRGNKDGMF 1245
            .|.:.|.||..|:.:|....|.:.|..| |.:.:..:|.:|.|...  |.||.:::..||:||.|
Frog  2233 SILLSDINDVVPKFELSPYTVSVPENLETLPKIILQVVARDDDQGL--NSRLTYSLASGNEDGAF 2295

  Fly  1246 ELRQIDAWNAQIFASKSLRNRYGN-YSLTITTRDMGLPANIVHNTLDICVSDFNDHAPVFVRPLH 1309
            .|..    :.|:...|||...... |||.||..|.|.||.....|:.|.|.|.||:.|.|.  |:
Frog  2296 TLSS----SGQLSLIKSLDREVKEWYSLLITATDAGFPALTGTGTISIQVEDINDNKPTFA--LN 2354

  Fly  1310 NTTVRIPENATVGTLILQAYASDGDMGQNALVRYRLKPDPLGSYKMFEVDGSTGELFLKEQLNRE 1374
            :..:.|||:|..||.||....||.|.|||.::||.|.    |....|.::.|||::.....|:||
Frog  2355 HHFITIPEDAPTGTDILMVNCSDSDAGQNGVIRYSLN----GGNSQFTINPSTGQIISSSLLDRE 2415

  Fly  1375 KQKIHEIRIEAYDQGLPTSLSSDLDLTIYVRNVNDYEPQFMVNEISVNFTEHSDPGSERIKLPDT 1439
            .:..:.:.:.|.|.|.| .|:|..::|:.:|:|||..|:|:.:....:....:..||....:..|
Frog  2416 AKDHYTLLVIATDGGSP-PLTSTTNVTVNIRDVNDNPPRFLHHPYVTHIPSPTTAGSFVFAVTVT 2479

  Fly  1440 IDKD---QLELDDPNDTPSQVCYFIVNGNEAGYFRLDPETHILTVDRELDREVIANFTLYVR-AT 1500
             |:|   ..||           :|.:.|..:..|.:||....:.....::......|:::|| ..
Frog  2480 -DEDIGSNAEL-----------HFSLKGRNSEKFHIDPLRGAIRTAGAIEGASEITFSVHVRDGG 2532

  Fly  1501 ENCRND----SISGGEK---------RRRMGIEINNRLGGIVHNQQFGYD-------------RF 1539
            .|.:.|    ::....|         |:......|..:|.:| :..||..             .|
Frog  2533 LNSKTDLTTVTVRFANKADFPLIRADRKTFTFPENQEVGTLV-STIFGSSSRGGSLSFYIASGNF 2596

  Fly  1540 KHSRQLRSTESNEY--GPEDAELL-SYEAYDSSQEDPTGGLATTHPELDSTVIKVKVRVLDINDN 1601
            .::..:.......|  .|.|.|.: .||.:..:::       ...|.. |:..|:::.|||:|||
Frog  2597 GNTFHIDELNGQLYIKNPLDFETMPKYELWVEARD-------MGFPPF-SSYEKLEITVLDVNDN 2653

  Fly  1602 PPRFRSKIFTGGITTNADFGLKFMRVEATDADEGDNGRIGYYQVGEIRQTLSEGLENVRKAPFLL 1666
            .|:|:...|...|..|.. ..|.:.:.|.|.|.|.||::.|        |:.:|   .::|.|.:
Frog  2654 QPQFKQDPFIAEIIENLS-PRKILTISAEDKDSGSNGQVEY--------TIFDG---NKEAFFSI 2706

  Fly  1667 DQETGEVQLNFDPQKGMKGYFDFVVLAND--TSGMKDVAHVFIYLLRE-DQKVRF--VFRLQPDE 1726
            ::..||::......:.....:...|.|:|  :.....:..|.||:|.: |...||  :|.....|
Frog  2707 NRVNGEIRNTRQLDREKASQYTLSVKASDKGSPARSSIVKVIIYVLDDNDNAPRFSQIFSAFVAE 2771

  Fly  1727 -----------LRSRVDSFRDTLS-------------NITESIVNIDEIKVHENKDGSVDK---- 1763
                       ..|..|:..:.:|             |:...::.:......|:.|..:.:
Frog  2772 NAVLGCFVTQVTTSDEDAGANAISRYTIADTSLPFHINLNTGVITVSRPLNREDNDRYIVRVSAH 2836

  Fly  1764 -----TKTDLYMHLVEREDN-------SIY-----------EVSEVLKLIDSHIESLNGLFKELN 1805
                 ..||:.:.:.:..||       |.|           :|::|. ..||. |.|||     :
Frog  2837 DSGWTVSTDVTIFVTDVNDNAPRFSKPSYYLDYPETLDIGSKVTQVF-ATDSD-EGLNG-----H 2894

  Fly  1806 VLDTQAAEAQLLTAGPSRGPLFVWLIFTNLFLATLLVVTIALCASQRNGYRRQLRAAKVNIFRGH 1870
            |.....::::|.....:.|.:|                     ..|...|:....:..:||.|..
Frog  2895 VYYFIKSQSELFRINSTTGEIF---------------------NKQHLKYQNPSVSGNININRHS 2938

  Fly  1871 SSMSLQDAQEPATRVPNTNKHSVQGSNPIWLKGYDNEWFKSEESGSIGGHDSLDDN--------- 1926
            ..:|..|                :||.||          .||.:.||...|| :||
Frog  2939 FIVSASD----------------RGSPPI----------MSETTVSINIVDS-NDNAPKFSSTKY 2976

  Fly  1927 FLAVATQDMHET--LKGTA---KLFNNSNDLNRHFNLYN-----QIDKMT 1966
            |..|:......|  :|.||   |.|..::::....:..|     ||||.|
Frog  2977 FTPVSKNAKIGTKLIKVTAVDDKDFGLNSEVGYSLSTENIHGKFQIDKET 3026

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.