Protein Alignment put and ACVRL1

DIOPT Version :10

• Sequence 1: NP_001262575.1
• Gene: put / 41772
• FlyBaseID: FBgn0003169
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_000011.2
• Gene: ACVRL1 / 94
• HGNCID: 175
• Length: 503
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 164/542 - (30%)
• Similarity: 253/542 - (46%)
• Gaps: 102/542 - (18%)

  Fly    13 LTLVCCLIGIHGSILPGSHGIIECEHFDEKMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNETT 77
            |.|:..|:.....:.|....::.|            .||:  .||     |.|:|...|..
Human    11 LMLLMALVTQGDPVKPSRGPLVTC------------TCES--PHC-----KGPTCRGAWCT---- 52

  Fly    78 GILRIKMKGCFTDMHECNQTECVTSAEPRQGNIH--FC-----------CCKGSRCNSNQKYIKS 129
             ::.::.:|    .|......|        ||:|  .|           ||....||.|   :..
Human    53 -VVLVREEG----RHPQEHRGC--------GNLHRELCRGRPTEFVNHYCCDSHLCNHN---VSL 101

  Fly   130 TTEATTQVPKEKTQDGSNLIYIYIGTSVFSVLMVIVG-MGLLLYRRRKQAHFNEIPTHEAEITNS 193
            ..|| ||.|.|:......|..| :|..:..:.:|.:| :||...|||::   .:...| :|:..|
Human   102 VLEA-TQPPSEQPGTDGQLALI-LGPVLALLALVALGVLGLWHVRRRQE---KQRGLH-SELGES 160

  Fly   194 SPLLS---------------------------------NRPIQLLEQKASGRFGDVWQAKLNNQD 225
            |.:|.                                 .|.:.|:|....||:|:||:...:.:.
Human   161 SLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGES 225

  Fly   226 VAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLG--VEKHMDKPEYWLISTYQHNGSLCDYLK 288
            ||||||..::::||..|.:||....:||.|||.|:.  :.......:.|||:.|..:|||.|:|:
Human   226 VAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQ 290

  Fly   289 SHTISWPELC-RIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGL 352
            ..|:. |.|. |:|.|.|.||||||.||  ..|.| ||:||||||||:|||:||:|..||||.||
Human   291 RQTLE-PHLALRLAVSAACGLAHLHVEI--FGTQG-KPAIAHRDFKSRNVLVKSNLQCCIADLGL 351

  Fly   353 AMIFQPGKPCGD--THGQVGTRRYMAPEVLEGAINFN-RDAFLRIDVYACGLVLWEMVSRCDFAG 414
            |::...|....|  .:.:|||:||||||||:..|..: .:::...|::|.||||||:..|....|
Human   352 AVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNG 416

  Fly   415 PVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLS 479
            .|.:::.||...:...||.:::::.|.:.:..|.:.|...|.|.|:.....|.|||..:..|||:
Human   417 IVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLT 481

  Fly   480 SSCVMERFAQLNKYPSTQLLIK 501
            :..:.:...:::..|....:|:
Human   482 ALRIKKTLQKISNSPEKPKVIQ 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	TFP_LU_ECD_ACVR2	33..125	CDD:467135	21/104 (20%)
		STKc_ACVR2	206..493	CDD:270955	114/292 (39%)
ACVRL1	NP_000011.2	TFP_LU_ECD_ALK1	29..98	CDD:467064	20/104 (19%)
		Mediates specificity for BMP ligand	73..76		1/2 (50%)
		TGF_beta_GS	174..200	CDD:462503	0/25 (0%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	116/300 (39%)