DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and ACVR2B

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_005265640.1	Gene:	ACVR2B / 93	HGNCID:	174	Length:	533	Species:	Homo sapiens

Alignment Length:	517	Identity:	246/517 - (47%)
Similarity:	327/517 - (63%)	Gaps:	44/517 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GSILPGSHGIIECEHFDEKMCNTTQQC-------------ETRIEHCKMEADKFPSCYVLWSVNE 75
            |..||...|..|.|         |::|             ::.:|.|:.|.||...||..|  ..
Human    33 GQPLPKGSGRGEAE---------TRECIYYNANWELERTNQSGLERCEGEQDKRLHCYASW--RN 86

  Fly    76 TTGILRIKMKGCFTDMHEC-NQTECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPK 139
            ::|.:.:..|||:.|...| ::.|||.:.|..|  ::||||:|:.|  |:::.........:|..
Human    87 SSGTIELVKKGCWLDDFNCYDRQECVATEENPQ--VYFCCCEGNFC--NERFTHLPEAGGPEVTY 147

  Fly   140 EKTQDGSNLIYIYIGTSVFSV--LMVIVGMGLLLYRRRKQAHFNEIPTHE-AEITNSSPLLSNRP 201
            |.......|:.: :..|:..:  |.:||.:...:||.||.. :..:..|| ......|||:..:|
Human   148 EPPPTAPTLLTV-LAYSLLPIGGLSLIVLLAFWMYRHRKPP-YGHVDIHEDPGPPPPSPLVGLKP 210

  Fly   202 IQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKHM 266
            :||||.||.||||.||:|:|.|..||||||.:|:|:||.:|.:|:..|.|:|.|:|:|:..||..
Human   211 LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRG 275

  Fly   267 D--KPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAH 329
            .  :.|.|||:.:...|||.||||.:.|:|.|||.:||:|:.||::|||::|..:.:|.||||||
Human   276 SNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAH 340

  Fly   330 RDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRI 394
            ||||||||||||||||.:||||||:.|:||||.||||||||||||||||||||||||.|||||||
Human   341 RDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRI 405

  Fly   395 DVYACGLVLWEMVSRCDFA-GPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPG 458
            |:||.||||||:||||..| |||.|:.||||.|:|..|||:|:||.||.||:||.:.:.|..|||
Human   406 DMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPG 470

  Fly   459 LNVFCDTMEECWDHDAEARLSSSCVMERFA----QLNKYPSTQL--LIKNHTNID-DAKEST 513
            |...|.|:|||||||||||||:.||.||.:    .:|...|..|  |:.:.||:| ..|||:
Human   471 LAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLPPKESS 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	28/101 (28%)
		STKc_ACVR2	206..493	CDD:270955	183/293 (62%)
		S_TKc	210..479	CDD:214567	173/271 (64%)
ACVR2B	XP_005265640.1	Activin_recp	48..138	CDD:279413	27/95 (28%)
		STKc_ACVR2b	215..505	CDD:271042	182/289 (63%)
		S_TKc	219..492	CDD:214567	174/272 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1722
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1685
Isobase	1	0.950	-	0	Normalized mean entropy	S2166
OMA	1	1.010	-	-		QHG49534
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0001838
OrthoInspector	1	1.000	-	-		otm41177
orthoMCL	1	0.900	-	-		OOG6_104478
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5044
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.860