DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and ACVR2A

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001265508.1	Gene:	ACVR2A / 92	HGNCID:	173	Length:	513	Species:	Homo sapiens

Alignment Length:	527	Identity:	251/527 - (47%)
Similarity:	334/527 - (63%)	Gaps:	43/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AQLTLVCCLIGIHGSILPGSHGIIECEHFD---EKMCNTTQQCETRIEHCKMEADKFPSCYVLWS 72
            |:|.....||......:.|.....||..|:   ||  :.|.|  |.:|.|..:.||...|:..|
Human     5 AKLAFAVFLISCSSGAILGRSETQECLFFNANWEK--DRTNQ--TGVEPCYGDKDKRRHCFATW- 64

  Fly    73 VNETTGILRIKMKGCFTDMHEC-NQTECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQ 136
             ...:|.:.|..:||:.|...| ::|:||...:..:  ::||||:|:.||....|...
Human    65 -KNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPE--VYFCCCEGNMCNEKFSYFPE------- 119

  Fly   137 VPKEKTQDGSNLIY---IYIGTSVFSV--LMVIVGM---GLLLYRRRKQAHFNE-IPTHEAEITN 192
              .|.||..||.:.   .|....::|:  ||:|.|:   ...:||..|.|:... :||.:.....
Human   120 --MEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPP 182

  Fly   193 SSPLLSNRPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNIL 257
            .||||..:|:||||.||.||||.||:|:|.|:.||||||.:|:|:||..|:::|.||.|:|.|||
Human   183 PSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENIL 247

  Fly   258 EFLGVEKH---MDKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASK 319
            :|:|.||.   :| .:.|||:.:...|||.|:||::.:||.|||.|||:||.|||:|||:||..|
Human   248 QFIGAEKRGTSVD-VDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK 311

  Fly   320 TDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAI 384
             ||.||:|:|||.||||||||::|||||||||||:.|:.||..||||||||||||||||||||||
Human   312 -DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAI 375

  Fly   385 NFNRDAFLRIDVYACGLVLWEMVSRCDFA-GPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPR 448
            ||.||||||||:||.||||||:.|||..| |||.|:.||||.|:|..|||:::||.||.||.||.
Human   376 NFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPV 440

  Fly   449 LLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYP---STQ---LLIKNHTNID 507
            |.:.|:.|.|:.:.|:|:|||||||||||||:.||.||..|:.:..   :|:   .::...||:|
Human   441 LRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVD 505

  Fly   508 -DAKEST 513
             ..|||:
Human   506 FPPKESS 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	28/91 (31%)
		STKc_ACVR2	206..493	CDD:270955	183/290 (63%)
		S_TKc	210..479	CDD:214567	173/272 (64%)
ACVR2A	NP_001265508.1	Activin_recp	38..114	CDD:395845	27/83 (33%)
ACVR2A	NP_001265508.1	STKc_ACVR2a	196..485	CDD:271043	183/290 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1722
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20391
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1685
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49534
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0001838
OrthoInspector	1	1.000	-	-		otm41177
orthoMCL	1	0.900	-	-		OOG6_104478
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.880