DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and Bmpr1a

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_110476.1	Gene:	Bmpr1a / 81507	RGDID:	70989	Length:	532	Species:	Rattus norvegicus

Alignment Length:	552	Identity:	170/552 - (30%)
Similarity:	259/552 - (46%)	Gaps:	99/552 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYLTAQLTLVCCLIGIHGSILPGSHGIIECEHFDEKMCNTTQQCETRIEHCKME-------ADKF 64
            ||...:|...|..|..|          ::.::.|..:..|..:.:  ::..|.|       .|..
  Rat     4 LYTYIRLLGACLFIISH----------VQGQNLDSMLHGTGMKSD--VDQKKPENGVTLAPEDTL 56

  Fly    65 P--SCYVLW-----SVNETTGILRIKMKGCFTDMHECNQ--TECVTSAEPRQGNIHFC------- 113
            |  .||...     ::|.|.    |....||..:.|.:|  |...:.....:|:...|
  Rat    57 PFLKCYCSGHCPDDAINNTC----ITNGHCFAIIEEDDQGETTLTSGCMKYEGSDFQCKDSPKAQ 117

  Fly   114 ------CCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGS-NLIYIYIGTSVFSVLMVIVGMGLLL 171
                  ||:.:.||   :|::.|.......|   ..||| ..:.:.|..:|..|.|::.. ....
  Rat   118 LRRTIECCRTNLCN---QYLQPTLPPVVIGP---FFDGSVRWLAVLISMAVCIVAMIVFS-SCFC 175

  Fly   172 YRR-----RKQAHFNE--------IPTHEA-----EITNSS------PLLSNR----PIQLLEQK 208
            |:.     ..:..:|.        ||..|:     :.:.||      |||..|    .||::.|.
  Rat   176 YKHYCKSISSRGRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV 240

  Fly   209 ASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLG--VEKHMDKPEY 271
            ..||:|:||..|...:.||||:|...|:.||..|.:||:...|||.|||.|:.  ::......:.
  Rat   241 GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQL 305

  Fly   272 WLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKN 336
            :||:.|..||||.|:||..|:....|.::|.|.|.||.|||.||..  |.| ||:|||||.||||
  Rat   306 YLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYG--TQG-KPAIAHRDLKSKN 367

  Fly   337 VLLKSDLTACIADFGLAMIFQPGKPCGDT-------HGQVGTRRYMAPEVLEGAINFNR-DAFLR 393
            :|:|.:.:.||||.|||:.|.     .||       :.:||||||||||||:.:::.|. ..::.
  Rat   368 ILIKKNGSCCIADLGLAVKFN-----SDTNEVDIPLNTRVGTRRYMAPEVLDESLSKNHFQPYIM 427

  Fly   394 IDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPG 458
            .|:|:.||::|||..||...|.|.|:|||:...:...||.::::|.|.:|:|||.:.|.|.:...
  Rat   428 ADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDEC 492

  Fly   459 LNVFCDTMEECWDHDAEARLSSSCVMERFAQL 490
            |......|.|||.|:..:||::..:.:..|::
  Rat   493 LRAVLKLMSECWAHNPASRLTALRIKKTLAKM 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	22/116 (19%)
		STKc_ACVR2	206..493	CDD:270955	119/295 (40%)
		S_TKc	210..479	CDD:214567	116/278 (42%)
Bmpr1a	NP_110476.1	Activin_recp	59..138	CDD:279413	17/85 (20%)
		Mediates specificity for BMP ligand. /evidence=ECO:0000250	107..109		0/1 (0%)
		S_TKc	235..519	CDD:214567	119/291 (41%)
		STKc_BMPR1a	238..524	CDD:271122	119/293 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910