DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and Acvr1

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_017447543.1	Gene:	Acvr1 / 79558	RGDID:	620200	Length:	528	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	170/506 - (33%)
Similarity:	250/506 - (49%)	Gaps:	87/506 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 EHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMHECNQTECVTSAEPRQGNIHFCCCKGSR 119
            :||:.:     .|:...|||:.   .|:..|||| .::|..:..|.|...|.|.   ..||:|..
  Rat    65 DHCEGQ-----QCFSSLSVNDG---FRVYQKGCF-QVYEQGKMTCKTPPSPGQA---VECCQGDW 117

  Fly   120 CNSNQKYIKSTTEATTQVP-KEKTQDGSNLIYIYIGTSVFSVLMV------IVGMGLLLYRRRKQ 177
            ||.|         .|.::| |.|:..||...::.:|..:.||:..      |:|:.|..::||.|
  Rat   118 CNRN---------VTARLPTKGKSFPGSQNFHLEVGLIILSVVFAVCLFACILGVALRKFKRRNQ 173

  Fly   178 AHFN----EIPTHEAEITNS------SPLLSN-------------------RPIQLLEQKASGRF 213
            ...|    |..|.|..||.:      :.||.:                   |.|.|||....||:
  Rat   174 ERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRY 238

  Fly   214 GDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLG---VEKHMDKPEYWLIS 275
            |:||:.....::||||||..::::||..|.::|....:||.|||.|:.   ..:| ...:.|||:
  Rat   239 GEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRH-SSTQLWLIT 302

  Fly   276 TYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLK 340
            .|...|||.|||:..|:......||..|:|:||||||.||  ..|.| |.:|||||.||||:|:|
  Rat   303 HYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEI--FGTQG-KSAIAHRDLKSKNILVK 364

  Fly   341 SDLTACIADFGLAMIFQPGKPCGD--THGQVGTRRYMAPEVLEGAINFN-RDAFLRIDVYACGLV 402
            .:...||||.|||::........|  .:.:|||:||||||||:..|..: .|::.|:|::|.|||
  Rat   365 KNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLV 429

  Fly   403 LWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTME 467
            |||:..|....|.|.:::.||...:...||.:::::.|.:.:.||.:.|.|.:.|.|......|:
  Rat   430 LWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMK 494

  Fly   468 ECWDHDAEARLSSSCVMERFAQLNKYPSTQLLIKNH-TNIDDA--KESTNC 515
            |||..:..|||                 |.|.||.. |.||::  |..|:|
  Rat   495 ECWYQNPSARL-----------------TALRIKKTLTKIDNSLDKLKTDC 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	22/70 (31%)
		STKc_ACVR2	206..493	CDD:270955	111/292 (38%)
		S_TKc	210..479	CDD:214567	109/274 (40%)
Acvr1	XP_017447543.1	Activin_recp	56..121	CDD:395845	21/67 (31%)
		TGF_beta_GS	198..225	CDD:400699	2/26 (8%)
		STKc_ACVR1_ALK1	221..518	CDD:271044	120/317 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840