Protein Alignment put and TGFBR2

DIOPT Version :10

• Sequence 1: NP_001262575.1
• Gene: put / 41772
• FlyBaseID: FBgn0003169
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001394055.1
• Gene: TGFBR2 / 7048
• HGNCID: 11773
• Length: 628
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 172/555 - (30%)
• Similarity: 274/555 - (49%)
• Gaps: 104/555 - (18%)

  Fly    26 ILPGSHGIIE----CEHFDEKM--CNTTQQCETRIEHCKMEA--DKFPS--CYVLWSVNETTGIL 80
            |:..::|.::    |:..|.:.  |:..:.|   :.:|.:.:  :| |.  |..:|..|:.
Human    62 IVTDNNGAVKFPQLCKFCDVRFSTCDNQKSC---MSNCSITSICEK-PQEVCVAVWRKNDE---- 118

  Fly    81 RIKMKGCFTD---------MHECNQTECVTSAEPRQGNIHF-CCCKGSRCN-------------- 121
            .|.::....|         :.:....:|:...:.:.|...| |.|....||
Human   119 NITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEGRCKIRH 183

  Fly   122 --SNQKYIKSTTEAT-------TQVPKEKTQDGSN-----LIYIYIGTSVFSVLMVIVGMGLLLY 172
              ||.:..:||.:.|       .:.|..:..:.||     :|:...|.|:...|.|.:.:.::.|
Human   184 IGSNNRLQRSTCQNTGWESAHVMKTPGFREYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFY 248

  Fly   173 -----------------RRRKQAHFNE-------------IPTHEAEITNSSPLLSNRPIQLLEQ 207
                             :.||...|:|             ..|....|.:::.||   ||:|...
Human   249 CYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELL---PIELDTL 310

  Fly   208 KASGRFGDVWQAKLNN------QDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKHM 266
            ...|||.:|::|||..      :.||||||..:|..||.||.||:....::|.|||:||..|:..
Human   311 VGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERK 375

  Fly   267 DK--PEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLH-EEIPASKTDGLKPSIA 328
            .:  .:||||:.:...|:|.:||..|.|||.:|.::..|:|.|:|||| :..|..:.   |..|.
Human   376 TELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRP---KMPIV 437

  Fly   329 HRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGD--THGQVGTRRYMAPEVLEGAINF-NRDA 390
            |||.||.|:|:|:|||.|:.||||::...|.....|  ..|||||.|||||||||..:|. |.::
Human   438 HRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVES 502

  Fly   391 FLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRA 455
            |.:.|||:..||||||.|||:..|.|.:::.||.:::...|.::.::::|:..:.||.:.:.|..
Human   503 FKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLN 567

  Fly   456 HPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQL 490
            |.|:.:.|:|:.||||||.||||::.||.|||::|
Human   568 HQGIQMVCETLTECWDHDPEARLTAQCVAERFSEL 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	TFP_LU_ECD_ACVR2	33..125	CDD:467135	21/127 (17%)
		STKc_ACVR2	206..493	CDD:270955	126/297 (42%)
TGFBR2	NP_001394055.1	ecTbetaR2	74..177	CDD:462632	19/110 (17%)
		STKc_TGFbR2_like	309..603	CDD:270957	126/297 (42%)