Protein Alignment put and TGFBR1

DIOPT Version :10

• Sequence 1: NP_001262575.1
• Gene: put / 41772
• FlyBaseID: FBgn0003169
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001293139.1
• Gene: TGFBR1 / 7046
• HGNCID: 11772
• Length: 507
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 169/517 - (32%)
• Similarity: 250/517 - (48%)
• Gaps: 90/517 - (17%)

  Fly    25 SILPGSHGIIECEHFDEKMCNTTQQCETRIEHCKM-EADKFPS-----CYVLWSVNETTG-ILRI 82
            ::|||:               |..||     .|.: ..|.|..     |:|  ||.|||. ::..
Human    26 ALLPGA---------------TALQC-----FCHLCTKDNFTCVTDGLCFV--SVTETTDKVIHN 68

  Fly    83 KMKGCFTDMHECNQTE---CVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQD 144
            .|  |..::....:..   |..|::.......:||        ||.:.......||.....|:..
Human    69 SM--CIAEIDLIPRDRPFVCAPSSKTGSVTTTYCC--------NQDHCNKIELPTTGPFSVKSSP 123

  Fly   145 G---SNLIYIYIGTSVFSVLMVIVGMGLLLY--RRRKQAHFNEIPTHE----------------- 187
            |   ..|..:..|    .|..|.:.:.|::|  ..|...| :.:|..|
Human   124 GLGPVELAAVIAG----PVCFVCISLMLMVYICHNRTVIH-HRVPNEEDPSLDRPFISEGTTLKD 183

  Fly   188 --AEITNSS-----PLLSNRPIQ----LLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTT 241
              .::|.|.     |||..|.|.    |.|....||||:||:.|...::||||||..:|:.||..
Human   184 LIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFR 248

  Fly   242 EHDIYKLPRMRHPNILEFLGVEKHMDK---PEYWLISTYQHNGSLCDYLKSHTISWPELCRIAES 303
            |.:||:...:||.|||.|:..: :.|.   .:.||:|.|..:|||.|||..:|::...:.::|.|
Human   249 EAEIYQTVMLRHENILGFIAAD-NKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALS 312

  Fly   304 MANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGD--TH 366
            .|:||||||.||..  |.| ||:|||||.||||:|:|.:.|.||||.|||:.........|  .:
Human   313 TASGLAHLHMEIVG--TQG-KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPN 374

  Fly   367 GQVGTRRYMAPEVLEGAINFNR-DAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLR 430
            .:|||:||||||||:.:||... ::|.|.|:||.|||.||:..||...|...::|||:...:...
Human   375 HRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSD 439

  Fly   431 PSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNK 492
            ||::|:::.|..:||||.:.|.|::...|.|....|.|||..:..|||::..:.:..:||::
Human   440 PSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQ 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	TFP_LU_ECD_ACVR2	33..125	CDD:467135	20/101 (20%)
		STKc_ACVR2	206..493	CDD:270955	123/293 (42%)
TGFBR1	NP_001293139.1	TFP_LU_ECD_ALK5	35..108	CDD:467067	20/89 (22%)
		TGF_beta_GS	180..207	CDD:462503	7/26 (27%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	122/290 (42%)