DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and bmpr2a

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_005165892.1	Gene:	bmpr2a / 562822	ZFINID:	ZDB-GENE-070618-1	Length:	1013	Species:	Danio rerio

Alignment Length:	483	Identity:	175/483 - (36%)
Similarity:	263/483 - (54%)	Gaps:	49/483 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 CYVLWSVNETTGILRIKMKGCFT---DMHECNQTECVTSAEP---RQGNIHFCCCKGSRCNSN-Q 124
            |:.||. .:..|::.:| :||:|   |..|| ...||.:..|   :.|...||||....||.| .
Zfish    70 CFGLWG-KKNNGVVLVK-QGCWTNVGDHQEC-YDRCVVTNPPSVAQNGTYRFCCCNKDMCNLNFT 131

  Fly   125 KYIKSTTEATTQVPKEKTQDGSNLIYIYIGT-SVFSVLMVIVGMGLLLYRRRKQAHFNEIPTHEA 188
            :.....:..|.|..:.:......:|.:.:.| |:.:||::::..|..:.|.|.:...:.:...|.
Zfish   132 EDFPPPSPTTAQPLQSRRLHREEVIVVALATVSMVAVLVILLFFGYRMLRGRGKHSLHTLNILET 196

  Fly   189 EITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRH 253
            .::..|..|.|..:|  |....||:|.|::|.|:::.||||:|....::.:|.|..||:| .:.|
Zfish   197 ALSPPSLDLDNLTLQ--ELIGRGRYGTVYRASLDDRSVAVKVFISANRQQFTNERMIYRL-LLDH 258

  Fly   254 PNILEFLGVEKHM---DKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEI 315
            .||..||..|:.:   .:.|:.|:..:..:||||.||...|:.|...||:|.|:..|||:||.||
Zfish   259 ENIARFLESEERVGTEGRTEFLLLLEFYPHGSLCTYLSGRTVDWLSCCRLALSVTRGLAYLHTEI 323

  Fly   316 PASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHG--------QVGTR 372
              .:.|..||:::|||..|:|||:|:|.:..|:||||:||....:|.|  ||        :|||.
Zfish   324 --QRGDVYKPAVSHRDLNSRNVLVKTDGSCVISDFGLSMILTGKRPPG--HGEEDNSAISEVGTV 384

  Fly   373 RYMAPEVLEGAINFNRD---AFLRIDVYACGLVLWEMVSRCD--FAG-PVGEFQLPFEAELGLRP 431
            |||||||||||:|. ||   |..::||||.|||.||...||.  |.| .|..|||.|:||:|..|
Zfish   385 RYMAPEVLEGAVNL-RDCESALKQVDVYALGLVYWETFMRCADLFPGETVPAFQLAFQAEVGNHP 448

  Fly   432 SLDEVQESVVMKKLRPRLLNSWRAHPGLNVFC--DTMEECWDHDAEARLSSSCVMERFAQL---- 490
            :::::|..|..:|.||:...:|:.: .|.|..  :|||:|||.||||||::.|..||.|:|
Zfish   449 TIEDMQALVSREKERPKFPEAWKEN-SLTVHSLKETMEDCWDQDAEARLTAQCAEERLAELLLIW 512

  Fly   491 --NKYPSTQL----LIKNHTNIDDAKES 512
              .|..|..|    .:.||.|....:::
Zfish   513 DREKSASPALNHSTALYNHRNFSAGRQT 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	22/65 (34%)
		STKc_ACVR2	206..493	CDD:270955	132/311 (42%)
		S_TKc	210..479	CDD:214567	125/287 (44%)
bmpr2a	XP_005165892.1	Activin_recp	64..134	CDD:279413	22/66 (33%)
		S_TKc	209..499	CDD:214567	128/298 (43%)
		STKc_BMPR2_AMHR2	212..508	CDD:270956	131/302 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820