DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and acvr1bb

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_687633.5	Gene:	acvr1bb / 559222	ZFINID:	ZDB-GENE-131120-9	Length:	498	Species:	Danio rerio

Alignment Length:	510	Identity:	173/510 - (33%)
Similarity:	258/510 - (50%)	Gaps:	74/510 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ILPGSHGIIECEHFDEKMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTD 90
            :|.|.:|:  |   |..:||.|      ..||  |.|.| .|....:...:|.::    :|....
Zfish    12 VLSGLNGV--C---DALLCNCT------APHC--ERDGF-KCETNGACVASTSVI----EGQEQH 58

  Fly    91 MHEC-NQTECVTSAEP-----RQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLI 149
            :..| ::.:.|...:|     .:|.::..||....|||    |.......|..|......|...:
Zfish    59 VRLCIHKEKLVPPGQPFYCLSAEGLMNTHCCYTDYCNS----IDLRLPIVTNGPGAGQDWGPVEL 119

  Fly   150 YIYIGTSVFSVLMVIVGMGLLLYRRRKQAHFN------EIPTHE--------------AEITNSS 194
            ...:...|| ||.|:|.:||.|::..::|:.:      |.|:.|              .:::.|.
Zfish   120 TAVVAGPVF-VLCVLVLLGLFLFQHHQRAYGHRQRLEVEDPSTEHMFLAKDKTLQDLIYDLSTSG 183

  Fly   195 -----PLLSN----RPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPR 250
                 ||...    |.|.|.|....||||:||:.|....|||||||..:|:.||..|.:||:...
Zfish   184 SGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTIM 248

  Fly   251 MRHPNILEFLGVEKHMDK---PEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLH 312
            :||.|||.|:..: :.|.   .:.||:|.|..||||.|||..::::...:.::|.|.|:||||||
Zfish   249 LRHENILGFIAAD-NKDNGTWTQLWLVSDYHENGSLFDYLNRYSVTIEGMIKLALSAASGLAHLH 312

  Fly   313 EEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDT-----HGQVGTR 372
            .||..  |.| ||.|||||.||||:|:|.:.|..|||.|||:..:   ...||     :.:|||:
Zfish   313 MEILG--TQG-KPGIAHRDLKSKNILVKKNCTCAIADLGLAVRHE---SITDTIDIAPNQRVGTK 371

  Fly   373 RYMAPEVLEGAINFNR-DAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEV 436
            |||||||||.:||... |:|...|:||.|||.||:..||:..|...|:|||:...:...||::|:
Zfish   372 RYMAPEVLEESINMRHFDSFKCADIYALGLVYWEIARRCNAGGIHEEYQLPYYDLVPSDPSIEEM 436

  Fly   437 QESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLN 491
            ::.|..::|||.:.|.|:::..|.|....|.|||..:..|||::..:.:..:||:
Zfish   437 RKVVCDQRLRPNIPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTLSQLS 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	21/93 (23%)
		STKc_ACVR2	206..493	CDD:270955	125/295 (42%)
		S_TKc	210..479	CDD:214567	121/277 (44%)
acvr1bb	XP_687633.5	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910