DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment put and acvr2b

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001006871.1	Gene:	acvr2b / 448641	XenbaseID:	XB-GENE-484248	Length:	510	Species:	Xenopus tropicalis

Alignment Length:	496	Identity:	240/496 - (48%)
Similarity:	317/496 - (63%)	Gaps:	32/496 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ECEHFDE--KMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMHEC-NQ 96
            ||.:::.  ::..|.|   :.:|.|:.|.||...||..|..|  :|.:.:..|||:.|...| ::
Frog    29 ECIYYNANWELEKTNQ---SGVESCEGEKDKRLHCYASWRNN--SGFIELVKKGCWLDDFNCYDR 88

  Fly    97 TECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIYIGTSVFSVL 161
            .||:...|..|  :.||||:|:.||   |......|..|..||.:.......|.||....:..:.
Frog    89 QECIAKEENPQ--VFFCCCEGNYCN---KKFTHLPEVETFDPKPQPPASVLNILIYSLLPIAGLS 148

  Fly   162 MVIVGMGLLLYRRRKQAH----FNEIPTHEAEITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLN 222
            |.|: :...:||.||..:    .||.|....    .||::..:|:||||.||.||||.||:|:|.
Frog   149 MAIL-LAFWMYRHRKPPYGHVDINEDPGPPP----PSPMVGLKPLQLLEIKARGRFGCVWKARLL 208

  Fly   223 NQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKHMD--KPEYWLISTYQHNGSLCD 285
            |:.||||||.:|:|:||..|.:|:....|:|.|:|||:..||...  :.|.|||:.:...|||.|
Frog   209 NEYVAVKIFPIQDKQSWQCEKEIFNTVGMKHENLLEFIAAEKRGSNLEMELWLITAFHDKGSLTD 273

  Fly   286 YLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADF 350
            |||.:.::|.|||.|.|:||.|||:|||::|..|.:|.||:|||||||||||||::||||.:|||
Frog   274 YLKGNLVTWNELCHITETMARGLAYLHEDVPRCKGEGHKPAIAHRDFKSKNVLLRNDLTAILADF 338

  Fly   351 GLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLRIDVYACGLVLWEMVSRCDFA-G 414
            |||:.|:||||.||||||||||||||||||||||||.||:|||||:||.||||||:||||..| |
Frog   339 GLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDSFLRIDMYAMGLVLWEIVSRCTAADG 403

  Fly   415 PVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLS 479
            ||.|:.||||.|:|..|||:::||.||.||:||...:.|..||||...|.|:|||||||||||||
Frog   404 PVDEYMLPFEEEIGQHPSLEDLQEVVVHKKMRPVFKDHWLKHPGLAQLCVTIEECWDHDAEARLS 468

  Fly   480 SSCVMERFAQLNKYPSTQL------LIKNHTNID-DAKEST 513
            :.||.||.:|:.|..:...      ::.:.||:| ..|||:
Frog   469 AGCVEERISQIRKSVNGTTSDCLVSIVTSVTNVDLPPKESS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	28/90 (31%)
		STKc_ACVR2	206..493	CDD:270955	180/289 (62%)
		S_TKc	210..479	CDD:214567	170/271 (63%)
acvr2b	NP_001006871.1	Activin_recp	42..114	CDD:366445	29/81 (36%)
acvr2b	NP_001006871.1	STKc_ACVR2b	192..482	CDD:271042	180/289 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I1690
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1649
OMA	1	1.010	-	-		QHG49534
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0001838
OrthoInspector	1	1.000	-	-		otm48388
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.080