DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and wit

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001261395.1	Gene:	wit / 44096	FlyBaseID:	FBgn0024179	Length:	913	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	166/511 - (32%)
Similarity:	261/511 - (51%)	Gaps:	90/511 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMHE----CNQTECVTSA-EPRQGNIHFCCC 115
            |.:...|.:..|:.:|  |:|....|:..:||:.|..:    |:|:||.:|| ..:..::::|||
  Fly    65 HRRTCPDGYTFCFTIW--NQTANGARVVKQGCWKDNTDRTSICSQSECTSSAPTSKTSSLYYCCC 127

  Fly   116 KGSRCNSNQKYIK------STTEATTQVPKEKTQD------GSNLIYIYIGTSVFSVLMVIVGMG 168
            .|..||:....::      .:.|..|.:....|:.      .|.::.:..|.:..::       |
  Fly   128 SGGVCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTI-------G 185

  Fly   169 LLL---YRRRKQAHFNEIPTHEAEITNSSPLLSNRP-----------IQLLEQKASGRFGDVWQA 219
            :.|   |.|..:    |.|..|     .|||..:.|           :.|:....||::|.|.:.
  Fly   186 IFLAVQYCRTAK----EKPEPE-----ESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKG 241

  Fly   220 KLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKH--MD-KPEYWLISTYQHNG 281
            .|::|:|||||:..:..:.:..|.:||.||.|..|.:|.:.|.::.  || :.||.|:.:....|
  Fly   242 LLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLG 306

  Fly   282 SLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTAC 346
            .|.|:|.::|:::.|.|.:..|:..|::|||.|:...  |..||.:||||..::|||:::||:.|
  Fly   307 CLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLG--DQHKPCVAHRDINTRNVLVQADLSCC 369

  Fly   347 IADFGLAMIFQPGKPCGDTH--------------GQVGTRRYMAPEVLEGAINFNRD---AFLRI 394
            |||||.|:     |..|..:              .:|||.||||||:||||:|. ||   :..::
  Fly   370 IADFGFAL-----KVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNL-RDCETSLKQM 428

  Fly   395 DVYACGLVLWEMVSRC-DFAGPVGE----FQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWR 454
            ||||.||||||:.:|| ||..| |:    ::.|:|.|:|..||.|::|..||..|.||.....|.
  Fly   429 DVYALGLVLWEVATRCSDFYAP-GQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWG 492

  Fly   455 AHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLN-------KYPSTQLLIKNH 503
            ......|..||.|:||||||:|||:|.|..||..:::       ..||:.||..|:
  Fly   493 GGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNN 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	22/74 (30%)
		STKc_ACVR2	206..493	CDD:270955	122/318 (38%)
		S_TKc	210..479	CDD:214567	117/293 (40%)
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	20/69 (29%)
		STYKc	226..517	CDD:214568	118/299 (39%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	122/308 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445037
Domainoid	1	1.000	55	1.000	Domainoid score	I10939
eggNOG	1	0.900	-	-		E2759_KOG3653
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	199	1.000	Inparanoid score	I2480
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900