DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and tkv

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	165/528 - (31%)
Similarity:	240/528 - (45%)	Gaps:	73/528 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PGSHGIIECEHFDEK--------MCNTTQQCETRIEHCKMEADKFPSCY--VLWSVNETTGIL-R 81
            |||.|..:.::...|        .|.....|...:.:...|.....||:  |....:||||:. .
  Fly    59 PGSEGYEDADNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEE 123

  Fly    82 IKMKGCFTDMHECNQTECVTSAEPR-QGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDG 145
            .:..||...........|..:|.|. .|....||.|...|| ...|...|.:.||..|.......
  Fly   124 ERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCN-RDLYPTYTPKLTTPAPDLPVSSE 187

  Fly   146 SNLIYIYIGTSV--FSVLMVIVGMGLLLYRRRKQ----------------AHFNEIPTHEAEITN 192
            |.......|:.:  .||.|:||......|:||::                :..:::....:...:
  Fly   188 SLHTLAVFGSIIISLSVFMLIVASLCFTYKRREKLRKQPRLINSMCNSQLSPLSQLVEQSSGSGS 252

  Fly   193 SSPLLSNR----PIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRH 253
            ..|||..|    .||::.....||:|:||.||..::.||||.|...|:.||..|.:||:...|||
  Fly   253 GLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRH 317

  Fly   254 PNILEFLG--VEKHMDKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIP 316
            .|||.|:.  ::.:....:..||:.|...|||.|||....|:..:|..:|.|:|:||||||:||
  Fly   318 DNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEI- 381

  Fly   317 ASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAM----------IFQPGKPCGDTHGQVGT 371
             ..|.| ||:|||||.||||:|:|.:....|||||||:          |.|        :.:|||
  Fly   382 -FGTPG-KPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQ--------NPRVGT 436

  Fly   372 RRYMAPEVLEGAINFNR-DAFLRIDVYACGLVLWEMVSRCDFAGPVG--------EFQLPFEAEL 427
            |||||||||...::..: :.|.|.|:|:.|||||||..||  ..||.        ::.||:...:
  Fly   437 RRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRC--YTPVSGTKTTTCEDYALPYHDVV 499

  Fly   428 GLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNK 492
            ...|:.:::...|.:|..||.:.:.|:....|......|:|||..:...||::..|.:...:|
  Fly   500 PSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL-- 562

  Fly   493 YPSTQLLI 500
              .|..||
  Fly   563 --ETDCLI 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	22/99 (22%)
		STKc_ACVR2	206..493	CDD:270955	115/307 (37%)
		S_TKc	210..479	CDD:214567	112/289 (39%)
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	22/90 (24%)
		GS	238..266	CDD:197743	4/27 (15%)
		S_TKc	267..557	CDD:214567	115/302 (38%)
		STKc_BMPR1	270..562	CDD:271046	114/304 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445035
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940