Protein Alignment put and acvr1l

DIOPT Version :10

• Sequence 1: NP_001262575.1
• Gene: put / 41772
• FlyBaseID: FBgn0003169
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_571420.1
• Gene: acvr1l / 30615
• ZFINID: ZDB-GENE-990415-9
• Length: 506
• Species: Danio rerio
• Alignment Length: 527
• Identity: 170/527 - (32%)
• Similarity: 245/527 - (46%)
• Gaps: 110/527 - (20%)

  Fly    44 CNTTQQCETRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMHECNQTECVTSAEPRQG 108
            || .|||         ..|:   ||.  ||..:..:...| :||.........| |..:|...
Zfish    35 CN-EQQC---------TGDQ---CYT--SVIISNDVTTFK-RGCLIGPASKRMT-CSATASAS-- 80

  Fly   109 NIHFC-CCKGSRCNSNQKYIKST-TEATTQVPKEKTQDGSNLIYIYIGTSVFSVLMVIVGMGL-- 169
              |.. ||....||:|..  |.| .......|:||     ..::..:...|..||...|.:||
Zfish    81 --HVVECCSQHMCNANVS--KETLLRLLLTSPEEK-----KTVHYRVEMLVLFVLGPFVVLGLLS 136

  Fly   170 ---LLYRRR----KQAHFNEIPTHEAEI---------------------TNSS----PLLSN--- 199
               ||..||    :....:|..|.:..|                     |:.|    |.|..
Zfish   137 FLALLVCRRLHHGRLERLHEFDTEQGAIDGLIASNVGDSTLADLMDHSCTSGSGSGLPFLVQRTV 201

  Fly   200 -RPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLG-- 261
             |.|.|:|....||:|:||:.:...::||||||..::::||..|.:||....:||.|||.|:.
Zfish   202 ARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMASD 266

  Fly   262 VEKHMDKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPS 326
            :.......:.|||:.|..||||.|||:...:...:...:|.|:|:||.|||.||  ..|:| ||:
Zfish   267 MTSRNSSTQLWLITHYHENGSLYDYLQRVAVEMADGLHMAASIASGLVHLHTEI--FGTEG-KPA 328

  Fly   327 IAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQ------------VGTRRYMAPEV 379
            |||||.||||:|:|.||..||||.|||:          ||.|            |||:|||||||
Zfish   329 IAHRDLKSKNILVKKDLQCCIADLGLAV----------THTQSDNQLDVGNNPKVGTKRYMAPEV 383

  Fly   380 LEGAINFN-RDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEVQESVVMK 443
            |:..|..: .||:.|:|::|.||||||:..|....|.|.|::.||...:...||.|::::.|.::
Zfish   384 LDETIQTDCFDAYKRVDIWAFGLVLWEIARRTISNGIVEEYKPPFYDLVPNDPSFDDMRKVVCVE 448

  Fly   444 KLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPSTQLLIKNHTNIDD 508
            :.||.:.|.|.:.|.|:.....|:|||..:..|||::..:            .:.|.|.|::::.
Zfish   449 QQRPFIPNRWFSDPTLSALVKLMKECWYQNPSARLTALRI------------KKTLDKIHSSLEK 501

  Fly   509 AKESTNC 515
            .|  |:|
Zfish   502 GK--TDC 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	TFP_LU_ECD_ACVR2	33..125	CDD:467135	22/81 (27%)
		STKc_ACVR2	206..493	CDD:270955	117/301 (39%)
acvr1l	NP_571420.1	TFP_LU_ECD_ALK2	26..95	CDD:467065	21/80 (26%)
		TGF_beta_GS	176..203	CDD:462503	4/26 (15%)
		STKc_ACVR1_ALK1	199..496	CDD:271044	122/321 (38%)