DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment put and acvrl1

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_021325397.1	Gene:	acvrl1 / 266753	ZFINID:	ZDB-GENE-021003-1	Length:	507	Species:	Danio rerio

Alignment Length:	522	Identity:	159/522 - (30%)
Similarity:	247/522 - (47%)	Gaps:	114/522 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SILPGSHGIIECEHFDEKMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCF- 88
            |.|......::|.      |..|..||..            ||   |.        ||    ||
Zfish    33 STLKNDESSLQCS------CENTNLCENN------------SC---WG--------RI----CFY 64

  Fly    89 TDMHE-----CNQT--ECVTSAEPRQGNIHFCCCKGSRCNSN-------------QKYIKSTTEA 133
            |.:||     |.||  :|...|.|   .::..||....||:|             :|.|:
Zfish    65 TSVHERVVRGCFQTAEQCYVPAIP---GVYTKCCYTHHCNANLTMPEKPVCLFSVEKPIR----- 121

  Fly   134 TTQVPKEKTQDGSNLIYIYIGTSVFSVLMV-IVGMGLLLYRRRKQAHFNEI-------------- 183
                           :.:.:|..:..:|:: :...||:|:.|.::.:.:.:
Zfish   122 ---------------VILLVGVPLLVLLVIAMAACGLVLWLRTRRQYCHPVEHDTSMLKVPSGGD 171

  Fly   184 PTH----EAEITNSS----PLLSN----RPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEK 236
            ||:    :...|:.|    |.|..    |.|.|:|....||:|:||:.....:.||||||..:::
Zfish   172 PTYGDIFDEFCTSGSGTGLPYLVQRTMARQISLVECVGKGRYGEVWRGTWMGESVAVKIFSSRDE 236

  Fly   237 ESWTTEHDIYKLPRMRHPNILEFLG--VEKHMDKPEYWLISTYQHNGSLCDYLKSHTISWPELC- 298
            :||..|.:||...::||.|||.|:.  :.......:.||::.:...|||.|:|:..|:. ||.|
Zfish   237 QSWFRETEIYNTVQLRHENILGFIASDMTSKNSSTQLWLVTHFHELGSLYDFLQYSTLD-PEGCL 300

  Fly   299 RIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCG 363
            |:..|:|:||.|||.||  ..|.| ||:|||||.||:|:|:|.:...||||.|||:|........
Zfish   301 RMCLSIASGLVHLHTEI--LSTQG-KPAIAHRDLKSRNILVKRNGQCCIADLGLAVIHSQSTDYL 362

  Fly   364 D--THGQVGTRRYMAPEVLEGAINFN-RDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEA 425
            |  |:.:|||:||||||||:..|..: .:::.:.|::|.||||||:..|....|.|.|::.||..
Zfish   363 DVGTNPRVGTKRYMAPEVLDETIRVDVFESYKQTDIWALGLVLWEITRRTIVNGIVEEYRPPFFD 427

  Fly   426 ELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQL 490
            .:...||.:|:::.|.:.:.||.|.|...:||.|:.....|:|||.....|||::..|.:..::|
Zfish   428 MVPSDPSFEEMKKVVCVDQHRPSLHNRLHSHPILSAIAKIMKECWFQSPSARLTALRVRKSLSKL 492

  Fly   491 NK 492
            ::
Zfish   493 DQ 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	25/108 (23%)
		STKc_ACVR2	206..493	CDD:270955	114/293 (39%)
		S_TKc	210..479	CDD:214567	110/274 (40%)
acvrl1	XP_021325397.1	TGF_beta_GS	173..200	CDD:312125	5/26 (19%)
acvrl1	XP_021325397.1	PKc_like	196..493	CDD:328722	116/300 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910