DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment put and Tgfbr2

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_033397.3	Gene:	Tgfbr2 / 21813	MGIID:	98729	Length:	592	Species:	Mus musculus

Alignment Length:	513	Identity:	171/513 - (33%)
Similarity:	262/513 - (51%)	Gaps:	80/513 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CEHFDEKM--CNTTQQCETRIEHCKMEA---DKFPSCYVLWSVNETTGIL-------RIKMKGCF 88
            |:..|.::  |:..:.|   :.:|.:.|   .....|..:|..|:....|       ::...| |
Mouse    76 CKFCDVRLSTCDNQKSC---MSNCSITAICEKPHEVCVAVWRKNDKNITLETVCHDPKLTYHG-F 136

  Fly    89 TDMHECNQTECVTSAEPRQGNIHF-CCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIY 152
            | :.:....:||...:.|.|...| |.|....||.   ||..:.|.||..|        :|:.:.
Mouse   137 T-LEDAASPKCVMKEKKRAGETFFMCACNMEECND---YIIFSEEYTTSSP--------DLLLVI 189

  Fly   153 I---GTSVFSVLMVIVGMGLLLY-----------------RRRKQAHFNE-------------IP 184
            |   |.|:...|.:.:.:.::.|                 :.||...|::             ..
Mouse   190 IQVTGVSLLPPLGIAIAVIIIFYCYRVHRQQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDISS 254

  Fly   185 THEAEITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLNN------QDVAVKIFRMQEKESWTTEH 243
            |....|.:::.||   ||:|......|||.:|::|||..      :.||||||..:|..||.||.
Mouse   255 TCANNINHNTELL---PIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKTEK 316

  Fly   244 DIYKLPRMRHPNILEFLGVEKHMDK--PEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMAN 306
            ||:....::|.|||:||..|:...:  .:||||:.:...|:|.:||..|.|||.:|.::..|:|.
Mouse   317 DIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLAR 381

  Fly   307 GLAHLH-EEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGD--THGQ 368
            |:|||| :..|..:.   |..|.|||.||.|:|:|:|||.|:.||||::...|.....|  ..||
Mouse   382 GIAHLHSDHTPCGRP---KMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 443

  Fly   369 VGTRRYMAPEVLEGAINF-NRDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPS 432
            |||.|||||||||..:|. |.::|.:.|||:..||||||.|||:..|.|.:::.||.:::...|.
Mouse   444 VGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPC 508

  Fly   433 LDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQL 490
            ::.:::||:..:.||.:.:.|..|.|:.:.|:|:.||||||.||||::.||.|||::|
Mouse   509 VESMKDSVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFSEL 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	21/100 (21%)
		STKc_ACVR2	206..493	CDD:270955	127/297 (43%)
		S_TKc	210..479	CDD:214567	120/280 (43%)
Tgfbr2	NP_033397.3	ecTbetaR2	74..177	CDD:286061	24/108 (22%)
		STYKc	269..566	CDD:214568	128/299 (43%)
		STKc_TGFbR2_like	273..567	CDD:270957	127/297 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..592
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910