Protein Alignment put and Tgfbr1

DIOPT Version :10

• Sequence 1: NP_001262575.1
• Gene: put / 41772
• FlyBaseID: FBgn0003169
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_036019848.1
• Gene: Tgfbr1 / 21812
• MGIID: 98728
• Length: 544
• Species: Mus musculus
• Alignment Length: 469
• Identity: 161/469 - (34%)
• Similarity: 237/469 - (50%)
• Gaps: 64/469 - (13%)

  Fly    67 CYVLWSVNETTG-ILRIKMKGCFTDMHECNQTE---CVTSAEPRQGNIHFCCCKGSRCNSNQKYI 127
            |:|  ||.|||. ::...|  |..::....:..   |..|::.......:||        ||.:.
Mouse    91 CFV--SVTETTDKVIHNSM--CIAEIDLIPRDRPFVCAPSSKTGAVTTTYCC--------NQDHC 143

  Fly   128 KSTTEATTQVPKEKTQDG---SNLIYIYIGTSVFSVLMVIVGMGLLLY--RRRKQAHFNEIPTHE 187
            ......||....||...|   ..|..:..|    .|..|.:.:.|::|  ..|...| :.:|..|
Mouse   144 NKIELPTTGPFSEKQSAGLGPVELAAVIAG----PVCFVCIALMLMVYICHNRTVIH-HRVPNEE 203

  Fly   188 -------------------AEITNSS-----PLLSNRPIQ----LLEQKASGRFGDVWQAKLNNQ 224
                               .::|.|.     |||..|.|.    |.|....||||:||:.|...:
Mouse   204 DPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGE 268

  Fly   225 DVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKHMDK---PEYWLISTYQHNGSLCDY 286
            :||||||..:|:.||..|.:||:...:||.|||.|:..: :.|.   .:.||:|.|..:|||.||
Mouse   269 EVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAAD-NKDNGTWTQLWLVSDYHEHGSLFDY 332

  Fly   287 LKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFG 351
            |..:|::...:.::|.|.|:||||||.||..  |.| ||:|||||.||||:|:|.:.|.||||.|
Mouse   333 LNRYTVTVEGMIKLALSTASGLAHLHMEIVG--TQG-KPAIAHRDLKSKNILVKKNGTCCIADLG 394

  Fly   352 LAMIFQPGKPCGD--THGQVGTRRYMAPEVLEGAINFNR-DAFLRIDVYACGLVLWEMVSRCDFA 413
            ||:.........|  .:.:|||:||||||||:.:||... ::|.|.|:||.|||.||:..||...
Mouse   395 LAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIG 459

  Fly   414 GPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARL 478
            |...::|||:...:...||::|:::.|..:||||.:.|.|::...|.|....|.|||..:..|||
Mouse   460 GIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARL 524

  Fly   479 SSSCVMERFAQLNK 492
            ::..:.:..:||::
Mouse   525 TALRIKKTLSQLSQ 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	TFP_LU_ECD_ACVR2	33..125	CDD:467135	14/61 (23%)
		STKc_ACVR2	206..493	CDD:270955	123/293 (42%)
Tgfbr1	XP_036019848.1	TFP_LU_ECD_ALK5	71..145	CDD:467067	15/65 (23%)
		TGF_beta_GS	217..244	CDD:462503	7/26 (27%)
		STKc_TGFbR1_ACVR1b_ACVR1c	250..537	CDD:271045	122/290 (42%)