DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and Bmpr2

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_006245013.1	Gene:	Bmpr2 / 140590	RGDID:	71082	Length:	1052	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	182/521 - (34%)
Similarity:	273/521 - (52%)	Gaps:	58/521 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLYLTAQLTLVCCLIGIHGSILPGSHGIIECEHFDEKMC---NTTQQ----CETRIEH------C 57
            |:..||:|.          :||......|......|::|   :..||    .|:||.|      |
  Rat    20 LVSTTAELL----------NILSLQRAGITASQNQERLCAFKDPYQQDLGIGESRISHENGTILC 74

  Fly    58 KMEADKFPSCYVLWSVNETTGILRIKMKGCFT---DMHECNQTECVTSAEP---RQGNIHFCCCK 116
                .|..:||.||  .::.|.:.:..:||::   |..||:..|||.:..|   :.|...||||.
  Rat    75 ----SKGSTCYGLW--EKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCS 133

  Fly   117 GSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIYIGTSVFSVLMVIVGMGL-LLYRRRKQAHF 180
            ...||.|........:.|...|...:.....:|......||.:||:|.:..|. :|...|||. .
  Rat   134 TDLCNVNFTENFPPPDTTPLSPPHSSNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRKQG-L 197

  Fly   181 NEIPTHEAEITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDI 245
            :.:...||.....|..|.|  ::|||....||:|.|::..|:.:.||||:|....::::..|.:|
  Rat   198 HSVSMMEAAAAEPSLDLDN--LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNI 260

  Fly   246 YKLPRMRHPNILEFLGVEKHM---DKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANG 307
            |::|.|.|.||..|:..::.:   .:.||.|:..|..|||||.||..||..|...||:|.|:..|
  Rat   261 YRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRG 325

  Fly   308 LAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAM------IFQPGKPCGDTH 366
            ||:||.|:|  :.|..||:|:|||..|:|||:|:..|..|:||||:|      :.:||:......
  Rat   326 LAYLHTELP--RGDHYKPAISHRDLNSRNVLVKNGGTCVISDFGLSMRLTGNRLVRPGEEDNAAI 388

  Fly   367 GQVGTRRYMAPEVLEGAINFNRD---AFLRIDVYACGLVLWEMVSRCD--FAG-PVGEFQLPFEA 425
            .:|||.|||||||||||:|. ||   |..::|:||.||:.||:..||.  |.| .|.::|:.|:.
  Rat   389 SEVGTIRYMAPEVLEGAVNL-RDCESALKQVDMYALGLIYWEVFMRCTDLFPGESVPDYQMAFQT 452

  Fly   426 ELGLRPSLDEVQESVVMKKLRPRLLNSWRAHP-GLNVFCDTMEECWDHDAEARLSSSCVMERFAQ 489
            |:|..|:.:::|..|..:|.||:...:|:.:. .:....:|:|:|||.||||||::.|..||.|:
  Rat   453 EVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAE 517

  Fly   490 L 490
            |
  Rat   518 L 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	32/106 (30%)
		STKc_ACVR2	206..493	CDD:270955	123/301 (41%)
		S_TKc	210..479	CDD:214567	116/284 (41%)
Bmpr2	XP_006245013.1	Activin_recp	74..145	CDD:279413	24/76 (32%)
		S_TKc	218..509	CDD:214567	120/293 (41%)
		STKc_BMPR2_AMHR2	221..518	CDD:270956	122/299 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820