Protein Alignment put and Acvrl1

DIOPT Version :10

• Sequence 1: NP_001262575.1
• Gene: put / 41772
• FlyBaseID: FBgn0003169
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001264184.1
• Gene: Acvrl1 / 11482
• MGIID: 1338946
• Length: 517
• Species: Mus musculus
• Alignment Length: 503
• Identity: 163/503 - (32%)
• Similarity: 247/503 - (49%)
• Gaps: 74/503 - (14%)

  Fly    42 KMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNETTGILRIK------MKGCFTDMHECNQTECV 100
            |:.|.|  ||:  .|||.     |.|...|.   |..::|.:      .:||    ...||..|:
Mouse    44 KLVNCT--CES--PHCKR-----PFCQGSWC---TVVLVREQGRHPQVYRGC----GSLNQELCL 92

  Fly   101 TSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIYIGTSVFSVLMVIV 165
              ..|.:...|.||.: |.||.|   :....|| ||.|.|:.:..::|..|........||:.:.
Mouse    93 --GRPTEFLNHHCCYR-SFCNHN---VSLMLEA-TQTPSEEPEVDAHLPLILGPVLALPVLVALG 150

  Fly   166 GMGLLLYRRRKQAHFNEIPTH------------------------EAEITNSS----PLLSN--- 199
            .:||...|||::   .:...|                        :::.|..|    |.|..
Mouse   151 ALGLWRVRRRQE---KQRDLHSDLGESSLILKASEQADSMLGDFLDSDCTTGSGSGLPFLVQRTV 212

  Fly   200 -RPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLG-- 261
             |.:.|:|....||:|:||:...:.:.||||||..::::||..|.:||....:||.|||.|:.
Mouse   213 ARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASD 277

  Fly   262 VEKHMDKPEYWLISTYQHNGSLCDYLKSHTISWPELC-RIAESMANGLAHLHEEIPASKTDGLKP 325
            :.......:.|||:.|..:|||.|:|:..|:. |:|. |:|.|.|.||||||.||  ..|.| ||
Mouse   278 MTSRNSSTQLWLITHYHEHGSLYDFLQRQTLE-PQLALRLAVSAACGLAHLHVEI--FGTQG-KP 338

  Fly   326 SIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGD--THGQVGTRRYMAPEVLEGAINFN- 387
            :|||||.||:|||:||:|..||||.|||::........|  .:.:|||:||||||||:..|..:
Mouse   339 AIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDC 403

  Fly   388 RDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNS 452
            .:::...|::|.||||||:..|....|.|.:::.||...:...||.:::::.|.:.:..|.:.|.
Mouse   404 FESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNR 468

  Fly   453 WRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPSTQLLI 500
            ..|.|.|:.....|.|||..:..|||::..:.:...:|:..|....:|
Mouse   469 LAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHNPEKPKVI 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	TFP_LU_ECD_ACVR2	33..125	CDD:467135	26/88 (30%)
		STKc_ACVR2	206..493	CDD:270955	113/292 (39%)
Acvrl1	NP_001264184.1	TFP_LU_ECD_ALK1	45..112	CDD:467064	24/85 (28%)
		TGF_beta_GS	188..214	CDD:462503	4/25 (16%)
		STKc_ACVR1_ALK1	210..507	CDD:271044	114/300 (38%)