Protein Alignment put and Acvr2b

DIOPT Version :9

• Sequence 1: NP_001262575.1
• Gene: put / 41772
• FlyBaseID: FBgn0003169
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: XP_036010460.1
• Gene: Acvr2b / 11481
• MGIID: 87912
• Length: 557
• Species: Mus musculus
• Alignment Length: 511
• Identity: 239/511 - (46%)
• Similarity: 322/511 - (63%)
• Gaps: 48/511 - (9%)

  Fly    35 ECEHFDE--KMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMHEC-NQ 96
            ||.:::.  ::..|.|   :.:|.|:.|.||...||..|  ..::|.:.:..|||:.|...| ::
Mouse    49 ECIYYNANWELERTNQ---SGLERCEGEQDKRLHCYASW--RNSSGTIELVKKGCWLDDFNCYDR 108

  Fly    97 TECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIYIGTSVFSV- 160
            .|||.:.|..|  ::||||:|:.|  |:::.........:|..|.......|:.: :..|:..:
Mouse   109 QECVATEENPQ--VYFCCCEGNFC--NERFTHLPEPGGPEVTYEPPPTAPTLLTV-LAYSLLPIG 168

  Fly   161 -LMVIVGMGLLLYRRRKQAH------------------------FNEIPTHEAEITNSSPLLSNR 200
             |.:||.:...:||.||..:                        |..:|..:......|||:..:
Mouse   169 GLSLIVLLAFWMYRHRKPPYGHVDIHEVRQCQRWAGRRDGCADSFKPLPFQDPGPPPPSPLVGLK 233

  Fly   201 PIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMRHPNILEFLGVEKH 265
            |:||||.||.||||.||:|:|.|..||||||.:|:|:||.:|.:|:..|.|:|.|:|:|:..||.
Mouse   234 PLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKR 298

  Fly   266 MD--KPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEEIPASKTDGLKPSIA 328
            ..  :.|.|||:.:...|||.||||.:.|:|.|||.:||:|:.||::|||::|..:.:|.|||||
Mouse   299 GSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIA 363

  Fly   329 HRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEVLEGAINFNRDAFLR 393
            |||||||||||||||||.:||||||:.|:||||.||||||||||||||||||||||||.||||||
Mouse   364 HRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLR 428

  Fly   394 IDVYACGLVLWEMVSRCDFA-GPVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNSWRAHP 457
            ||:||.||||||:||||..| |||.|:.||||.|:|..|||:|:||.||.||:||.:.:.|..||
Mouse   429 IDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHP 493

  Fly   458 GLNVFCDTMEECWDHDAEARLSSSCVMERFA----QLNKYPSTQL--LIKNHTNID 507
            ||...|.|:|||||||||||||:.||.||.:    .:|...|..|  |:.:.||:|
Mouse   494 GLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVD 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	28/90 (31%)
		STKc_ACVR2	206..493	CDD:270955	183/293 (62%)
		S_TKc	210..479	CDD:214567	173/271 (64%)
Acvr2b	XP_036010460.1	Activin_recp	62..131	CDD:395845	27/77 (35%)
		STKc_ACVR2b	239..529	CDD:271042	182/289 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1695
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1661
Isobase	1	0.950	-	0	Normalized mean entropy	S2166
OMA	1	1.010	-	-		QHG49534
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0001838
OrthoInspector	1	1.000	-	-		otm43245
orthoMCL	1	0.900	-	-		OOG6_104478
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5044
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.860