DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and Acvr2a

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_006497686.1	Gene:	Acvr2a / 11480	MGIID:	102806	Length:	521	Species:	Mus musculus

Alignment Length:	532	Identity:	246/532 - (46%)
Similarity:	329/532 - (61%)	Gaps:	45/532 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AQLTLVCCLIGIHGSILPGSHGIIECEHFDEKMCNTTQQCETRIEHCKMEADKFPSCYVLWSVNE 75
            |:|.....||......:.|.....||..|:... ...:..:|.:|.|..:.||...|:..|  ..
Mouse     5 AKLAFAVFLISCSSGAILGRSETQECLFFNANW-ERDRTNQTGVEPCYGDKDKRRHCFATW--KN 66

  Fly    76 TTGILRIKMKGCFTDMHEC-NQTECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPK 139
            .:|.:.|..:||:.|...| ::|:|:...:..:  ::||||:|:.||....|...         .
Mouse    67 ISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPE--VYFCCCEGNMCNEKFSYFPE---------M 120

  Fly   140 EKTQDGSNLIY---IYIGTSVFSV--LMVIVGM---GLLLYRRRKQA---------HFNEIPTHE 187
            |.||..||.:.   .|....::|:  ||:|.|:   ...:||..|.|         |...|...:
Mouse   121 EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQHAFHIMIED 185

  Fly   188 AEITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRMR 252
            ......||||..:|:||||.||.||||.||:|:|.|:.||||||.:|:|:||..|:::|.||.|:
Mouse   186 PGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMK 250

  Fly   253 HPNILEFLGVEKH---MDKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHEE 314
            |.|||:|:|.||.   :| .:.|||:.:...|||.|:||::.:||.|||.|||:||.|||:|||:
Mouse   251 HENILQFIGAEKRGTSVD-VDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHED 314

  Fly   315 IPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGDTHGQVGTRRYMAPEV 379
            ||..| ||.||:|:|||.||||||||::|||||||||||:.|:.||..|||||||||||||||||
Mouse   315 IPGLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEV 378

  Fly   380 LEGAINFNRDAFLRIDVYACGLVLWEMVSRCDFA-GPVGEFQLPFEAELGLRPSLDEVQESVVMK 443
            |||||||.||||||||:||.||||||:.|||..| |||.|:.||||.|:|..|||:::||.||.|
Mouse   379 LEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHK 443

  Fly   444 KLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYP---STQ---LLIKN 502
            |.||.|.:.|:.|.|:.:.|:|:|||||||||||||:.||.||..|:.:..   :|:   .::..
Mouse   444 KKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTM 508

  Fly   503 HTNID-DAKEST 513
            .||:| ..|||:
Mouse   509 VTNVDFPPKESS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	23/88 (26%)
		STKc_ACVR2	206..493	CDD:270955	183/290 (63%)
		S_TKc	210..479	CDD:214567	173/272 (64%)
Acvr2a	XP_006497686.1	Activin_recp	<59..114	CDD:395845	17/58 (29%)
Acvr2a	XP_006497686.1	STKc_ACVR2a	204..493	CDD:271043	183/290 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	278	1.000	Domainoid score	I1695
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20391
Inparanoid	1	1.050	438	1.000	Inparanoid score	I1661
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49534
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0001838
OrthoInspector	1	1.000	-	-		otm43245
orthoMCL	1	0.900	-	-		OOG6_104478
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5044
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910