Protein Alignment put and Acvr1

DIOPT Version :10

• Sequence 1: NP_001262575.1
• Gene: put / 41772
• FlyBaseID: FBgn0003169
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_031420.2
• Gene: Acvr1 / 11477
• MGIID: 87911
• Length: 509
• Species: Mus musculus
• Alignment Length: 533
• Identity: 176/533 - (33%)
• Similarity: 256/533 - (48%)
• Gaps: 103/533 - (19%)

  Fly    40 DEK--------MCNTTQQCE----TRIEHCKMEADKFPSCYVLWSVNETTGILRIKMKGCFTDMH 92
            |||        ||    .||    ...:||:.:     .|:...|:|:.   ..:..|||| .::
Mouse    23 DEKPKVNQKLYMC----VCEGLSCGNEDHCEGQ-----QCFSSLSINDG---FHVYQKGCF-QVY 74

  Fly    93 ECNQTECVTSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVP-KEKTQDGSNLIYIYIGTS 156
            |..:..|.|...|.|.   ..||:|..||.|         .|.|:| |.|:..|:...::.:|..
Mouse    75 EQGKMTCKTPPSPGQA---VECCQGDWCNRN---------ITAQLPTKGKSFPGTQNFHLEVGLI 127

  Fly   157 VFSV------LMVIVGMGLLLYRRRKQAHFN----EIPTHEAEITNS------SPLLSN------ 199
            :.||      |..|:|:.|..::||.|...|    |..|.|..||.:      :.||.:
Mouse   128 ILSVVFAVCLLACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGS 192

  Fly   200 -------------RPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRM 251
                         |.|.|||....||:|:||:.....::||||||..::::||..|.::|....:
Mouse   193 GSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVML 257

  Fly   252 RHPNILEFLG---VEKHMDKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHE 313
            ||.|||.|:.   ..:| ...:.|||:.|...|||.|||:..|:......||..|:|:||||||.
Mouse   258 RHENILGFIASDMTSRH-SSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHI 321

  Fly   314 EIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGD--THGQVGTRRYMA 376
            ||  ..|.| |.:|||||.||||:|:|.:...||||.|||::........|  .:.:|||:||||
Mouse   322 EI--FGTQG-KSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMA 383

  Fly   377 PEVLEGAINFN-RDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDEVQESV 440
            ||||:..|..: .|::.|:|::|.||||||:..|....|.|.:::.||...:...||.:::::.|
Mouse   384 PEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVV 448

  Fly   441 VMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPSTQLLIKNH-T 504
            .:.:.||.:.|.|.:.|.|......|:|||..:..|||                 |.|.||.. |
Mouse   449 CVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARL-----------------TALRIKKTLT 496

  Fly   505 NIDDA--KESTNC 515
            .||::  |..|:|
Mouse   497 KIDNSLDKLKTDC 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	TFP_LU_ECD_ACVR2	33..125	CDD:467135	27/96 (28%)
		STKc_ACVR2	206..493	CDD:270955	111/292 (38%)
Acvr1	NP_031420.2	TFP_LU_ECD_ALK2	33..103	CDD:467065	24/94 (26%)
		TGF_beta_GS	179..206	CDD:462503	2/26 (8%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	120/317 (38%)