DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment put and bmpr2

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_002937761.3	Gene:	bmpr2 / 100494339	XenbaseID:	XB-GENE-479990	Length:	1053	Species:	Xenopus tropicalis

Alignment Length:	575	Identity:	182/575 - (31%)
Similarity:	286/575 - (49%)	Gaps:	83/575 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TLVCCLIGIHGSILPGSHGIIECEHFDEKMC------NTTQ---QCETRIEHCKMEADKFPSCYV 69
            ||:..::|:|.:.|..:....:.|   |::|      |..|   :.:..:|:..::..|...|:.
Frog    26 TLILLILGLHSTFLLATAPATQSE---ERLCAYKDPNNQDQALSESQISLENGTVKCTKGNICFG 87

  Fly    70 LWSVNETT--GILRIKMKGCF---TDMHECNQTECVTSAEP---RQGNIHFCCCKGSRCNSN--Q 124
            ||   |.|  |.:.:..:||:   :|..:|...||..:..|   :.|...||||....||.|  :
Frog    88 LW---EKTRDGEINLVRQGCWSHVSDSRDCYYEECAVTTPPPVIQNGTYRFCCCSKDMCNVNFTE 149

  Fly   125 KYIKS-TTEATTQVPKEKTQDGSNLIYIYIGTSVFSVLMVIVGMGLLLY--RRRKQAHFNEIPTH 186
            .:..| .|.|:...|.........:|......||.:||:|:...|..::  .|::..|...:
Frog   150 NFTPSDPTSASPYSPSGWLHREMTIIIALASISVLAVLIVVFFFGYRIFGGDRKQGLHSMNV--- 211

  Fly   187 EAEITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLNNQDVAVKIFRMQEKESWTTEHDIYKLPRM 251
             .|...|.|.|....::|||....||:|.|::..|:.:.||||:|....::::..|..||:.|.:
Frog   212 -LEAATSEPSLDLDNLKLLELIGRGRYGSVYKGSLDERPVAVKVFSFNNRQNFINERSIYRTPLL 275

  Fly   252 RHPNILEFLGVEKHM---DKPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLAHLHE 313
            .|.||..|:..::.:   .:.||.|:..|..||||..||..|:..|...||:|.|:..|||:||.
Frog   276 EHDNIAHFIAADERITSDGRLEYLLVMEYYANGSLSKYLSVHSNDWLNSCRLAHSVTKGLAYLHT 340

  Fly   314 EIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAM------IFQPGKPCGDTHGQVGTR 372
            |:  .:.|..|.:|:|||..|:|||:|||.|..|:||||:|      :.:||........:|||.
Frog   341 EL--LRGDNYKSAISHRDLNSRNVLVKSDGTCVISDFGLSMRLTGNRLVRPGDEDNAAISEVGTI 403

  Fly   373 RYMAPEVLEGAINFNRD---AFLRIDVYACGLVLWEMVSRCD--FAG-PVGEFQLPFEAELGLRP 431
            |||||||||||:|. ||   |..::|:||.||:.||:..||.  |.| .|.|:|:.|:.|.|..|
Frog   404 RYMAPEVLEGAVNL-RDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEAGNHP 467

  Fly   432 SLDEVQESVVMKKLRPRLLNSWRAHP-GLNVFCDTMEECWDHDAEARLSSSCVMERFAQL----- 490
            :.:::|..|..:|.||:...:|:.:. .:....:|:::|||.||||||::.|..||.|:|
Frog   468 TFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIDDCWDQDAEARLTAQCAEERMAELMMIWE 532

  Fly   491 -NKYPS-----TQLLIKNHTN---------------------IDDAKESTNCLXK 518
             ||..|     |...::|..|                     |:|:..:|:.: |
Frog   533 RNKSVSPTINPTSTAVQNERNLSQNRRVPKIGPYPDYSSSSYIEDSVHNTDSIVK 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	27/106 (25%)
		STKc_ACVR2	206..493	CDD:270955	121/308 (39%)
		S_TKc	210..479	CDD:214567	113/284 (40%)
bmpr2	XP_002937761.3	Activin_recp	66..147	CDD:395845	22/83 (27%)
bmpr2	XP_002937761.3	STKc_BMPR2_AMHR2	230..527	CDD:270956	119/299 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920