DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment put and tgfbr2

DIOPT Version :9

Sequence 1:	NP_001262575.1	Gene:	put / 41772	FlyBaseID:	FBgn0003169	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_031759578.1	Gene:	tgfbr2 / 100488582	XenbaseID:	XB-GENE-485606	Length:	810	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	165/510 - (32%)
Similarity:	256/510 - (50%)	Gaps:	81/510 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 CEH--FDEKMCNTTQQCETRIEHCKMEADKFPSCYVLW-----SVNETTGILRIKMKGCFTDMHE 93
            ||:  :...:||....||.:.|          .|..:|     ::.|.|.....|.:.....:.:
Frog   301 CENQGYCTSVCNIASVCEHQEE----------VCIAIWRNKDGNITEETMCHDPKKELYGYKLDD 355

  Fly    94 CNQTECV-TSAEPRQGNIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQ-DGS-----NLIYI 151
            .|:.||: ...:..:|.:..|.|:|..|          ||.....|..:|. |.|     .::.|
Frog   356 YNEKECIMKEKKTSEGIMSMCSCRGKLC----------TERFFFPPANETNIDPSKDILLKVLLI 410

  Fly   152 YIGTSVFSVLMVIVGMGLLLYRRRK--QAHFNEIP---------------------------THE 187
            .:...|:..:.||||......:|.|  :..:.:.|                           |..
Frog   411 TLLPLVWITIAVIVGFYFYRVQRTKKLKKKWEKNPKCMRHPDMDCSDACAIMIDDDRSDISSTCA 475

  Fly   188 AEITNSSPLLSNRPIQLLEQKASGRFGDVWQAKLNN------QDVAVKIFRMQEKESWTTEHDIY 246
            ..:.:::.||   ||:|......|||.:|::|||..      :.||||||..:|..||..|.||:
Frog   476 NNLNHNTELL---PIELDTLVGKGRFAEVYKAKLKQNTSEQYETVAVKIFHFEEYASWKMEKDIF 537

  Fly   247 KLPRMRHPNILEFLGVEKHMDK--PEYWLISTYQHNGSLCDYLKSHTISWPELCRIAESMANGLA 309
            ....::|.|:|:||..|:....  .:||||:.:...|:|.:||..|.|||.:|.::..|:|.|:|
Frog   538 SDMNLKHENVLQFLTAEERKTDTGKQYWLITAFHSKGNLQEYLSKHIISWEDLMKLGGSLARGVA 602

  Fly   310 HLH-EEIPASKTDGLKPSIAHRDFKSKNVLLKSDLTACIADFGLAMIFQPGKPCGD--THGQVGT 371
            ||| :..|..:.   |..|.|||.||.|:|:|:|||.|:.||||::..:|.....|  ..|||||
Frog   603 HLHSDHTPCGRP---KTPIVHRDIKSSNILVKNDLTCCLCDFGLSLWLEPSLSVDDLANSGQVGT 664

  Fly   372 RRYMAPEVLEGAINF-NRDAFLRIDVYACGLVLWEMVSRCDFAGPVGEFQLPFEAELGLRPSLDE 435
            .|||||||||..||. |.::|.:.|||:..|||||:.|||:..|.|.:::.||..::...|.::.
Frog   665 ARYMAPEVLESRINLENIESFKQTDVYSMALVLWEITSRCNAIGDVKDYEPPFGTKVREHPCVES 729

  Fly   436 VQESVVMKKLRPRLLNSWRAHPGLNVFCDTMEECWDHDAEARLSSSCVMERFAQL 490
            ::::|:..:.||.:.|||.:|.|:.:.|:|:.||||.|.||||::.||.|||:::
Frog   730 MKDNVLRDRGRPEISNSWLSHQGIQLVCETITECWDQDPEARLTAQCVEERFSEM 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
put	NP_001262575.1	Activin_recp	38..126	CDD:279413	18/95 (19%)
		STKc_ACVR2	206..493	CDD:270955	124/297 (42%)
		S_TKc	210..479	CDD:214567	118/280 (42%)
tgfbr2	XP_031759578.1	ecTbetaR2	43..143	CDD:401023
		ecTbetaR2	178..275	CDD:401023
		ecTbetaR2	290..391	CDD:401023	22/109 (20%)
		STKc_TGFbR2_like	491..785	CDD:270957	124/297 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010