Protein Alignment stumps and Pik3ap1

DIOPT Version :10

• Sequence 1: NP_731923.2
• Gene: stumps / 41770
• FlyBaseID: FBgn0020299
• Length: 1220
• Species: Drosophila melanogaster
• Sequence 2: NP_113553.1
• Gene: Pik3ap1 / 83490
• MGIID: 1933177
• Length: 811
• Species: Mus musculus
• Alignment Length: 973
• Identity: 198/973 - (20%)
• Similarity: 335/973 - (34%)
• Gaps: 295/973 - (30%)

  Fly   250 DILIITAKHSERAYLRATFLKNHFDKITKQRGRKPFNFLHIKIDDGPFSEEIAHKYQNTALQIVI 314
            ||||..:..:|.   ...:|::.|....:.|.:|...:.  .:.|..||.:....:::....:|:
Mouse    11 DILIFYSPDAEE---WCQYLQDLFVSCRQVRSQKTQTYR--LVPDASFSAQDLWVFRDARCVLVL 70

  Fly   315 LCPALLAL---PHSFLMTQLSAIIRVEKVLAILLDVSEEKVKEMHKSALPSYYKWRRCVVRDNDQ 376
            |...|:..   |....|.| .|....::|:.:|..|  :...|..::..|.:..|:.....|..:
Mouse    71 LSAGLVGCFGQPGLLPMLQ-RACHPPQRVVRLLCGV--QPGDEDFQAFFPDWAHWQEMTCDDEPE 132

  Fly   377 VQISNILGIATDILGRALCQRPPC--------QDSSGGGGGGLSRSFSSCTE-------G--FTV 424
            ..::.:        .:|:.:...|        :|..       ...||..|.       |  ..|
Mouse   133 TYLAAV--------RKAISEDSGCDSVTDTEPEDER-------ELPFSKQTNLPPEISPGNLMVV 182

  Fly   425 LPKKVKLGQNKVVALLAE-----------PLEKNDTLKLQVEKSGELIELRNFKCRNPYTLQFNI 478
            .|.:::.|....|.::..           .....|:..::||.:.|          |.||:....
Mouse   183 QPDRIRCGAETTVYIIVRCKLDEKVSTEAEFSPEDSPSIRVEGTLE----------NEYTVSVKA 237

  Fly   479 PEACMEISTMIEIRIEKNNKSLGARPIKCESRLRELEQLLRIEDSPIEFMCHALGIGPVERDALD 543
            |:..   |..:.:::...:..:....:...:.:.|:..||....:|:||||.|..|.|...:.||
Mouse   238 PDLS---SGNVSLKVYSGDLVVCETTVSYYTDMEEIGNLLSSAANPVEFMCQAFKIVPYNTETLD 299

  Fly   544 QHLLQCFQRNMPPN-FHLLSGPSERQPHFFTRLESSPEEYPTLLHFAARWGLNRLCIQLMECPGG 607
            :.|.:..:.|:|.: .||.......:....|  ....||.||||||||::||..|...|:.|||.
Mouse   300 KLLTESLKNNIPASGLHLFGINQLEEDDMMT--NQRDEELPTLLHFAAKYGLKNLTALLLTCPGA 362

  Fly   608 DTACGVRNCAGRTPAELAEQEGHHKLAQNIVSFAEFHEL-------------------TTMYH-- 651
            ..|..|.|..|..|..:||:.|...|.|.|..:.|..::                   .:|.|
Mouse   363 LQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDMLKTHIKEELMQGEEADDVYESMAHLS 427

  Fly   652 ---YFKGVTPPG------ES----CPKPSANVVIE------AHPVKAGKTNKPPKELPTAEYMEM 697
               ..|....||      ||    .|..:.::.:|      .:||.....::|.|:....:::|.
Mouse   428 TDLLMKCSLNPGCDDELYESMAAFAPAATEDLYVEMLQASAGNPVSGESFSRPTKDSMIRKFLEG 492

  Fly   698 SS----GSERENTPEVRTKTETLAISNLNYISVETEDENLQASVAEKKVESEKKLPEAGNQPGPE 758
            :|    ..|||   :.....|.|      |..|: |||.....:|.:......: ||| :.|||.
Mouse   493 NSVKPASWERE---QHHPYGEEL------YHIVD-EDETFSVDLANRPPVPVPR-PEA-SAPGPP 545

  Fly   759 KTTNELRINEPPYYQSK---EQNQQPKELKNQSKSLDEVDAAPLYQTDKFSQECSQLLENQLGND 820
            ...:    |||  |.||   |::|:                                   :|||.
Mouse   546 PPPD----NEP--YISKVFAEKSQE-----------------------------------RLGNF 569

  Fly   821 YVLQPSNVPVAQDDGNYLFQPSNRPVEEPLRLNRCTNRQPGYGTLKRSASDASAASHTRSNADDE 885
            ||   |:..:.::           |:..|.|     :|.|.      |..|..|...|....  :
Mouse   570 YV---SSESIRKE-----------PLVRPWR-----DRPPS------SIYDPFAGMKTPGQR--Q 607

  Fly   886 LAEIMHDFKNNVLSIRDVEVLVERWK-HRNDVQQSFREKQDQIDQLRREY-ERIQEQVKS----- 943
            |..:....|..::::.:..:..:.|: ::....:|||.:|:.:.:||... .|.:|:.||
Mouse   608 LITLQEQVKLGIVNVDEAVLHFKEWQLNQKKRSESFRFQQENLKRLRESITRRRKEKPKSGKHTD 672

  Fly   944 -----------HLKRETPF----ERIKKFFLRSKTPGGNDSLLDETKSSIATSCSFKSAGGVSSS 993
                       ||..:..|    ...:|..|.::|.........::.||.|:|.|.:|
Mouse   673 LEITVPIRHSQHLPEKVEFGVYESGPRKSVLPARTELRRGDWKTDSMSSTASSTSNRS------- 730

  Fly   994 AGAGRPISSLSLQSVSSSSSSSGRLSTGSNCSGASLGDSGTHSDHEDRRFPHCRMMDNYMVPPTP 1058
                   |:.||.|||                      ||...|:||...|.
Mouse   731 -------STRSLLSVS----------------------SGMEGDNEDNEIPE------------- 753

  Fly  1059 RPVFTPSSTPGD---ERHQIVFPSPMSSCQRLNTPTSPTGSEHYQMFPSNIPVYGSQPLVGSQ 1118
               .|.|..||.   :...:|..:|:.:.:|                |..:|     |...||
Mouse   754 ---ITRSRGPGPTQVDGAPVVTGTPVGTLER----------------PPRVP-----PRAASQ 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stumps	NP_731923.2	DBB	423..562	CDD:464205	31/150 (21%)
Pik3ap1	NP_113553.1	Necessary and sufficient to mediate inhibition of NF-kappa-B downstream of activated TLRs, may mediate interaction with MYD88 and TIRAP. /evidence=ECO:0000269|PubMed:22187460	10..145		27/149 (18%)
		TIR_3	11..142	CDD:436583	26/146 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..169		4/29 (14%)
		DBB	181..319	CDD:464205	31/150 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..551		7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	702..811		32/164 (20%)