DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stumps and PIK3AP1

DIOPT Version :9

Sequence 1:	NP_731923.2	Gene:	stumps / 41770	FlyBaseID:	FBgn0020299	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	NP_689522.2	Gene:	PIK3AP1 / 118788	HGNCID:	30034	Length:	805	Species:	Homo sapiens

Alignment Length:	916	Identity:	203/916 - (22%)
Similarity:	330/916 - (36%)	Gaps:	192/916 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 DILIITAKHSER--AYLRATFLKNHFDKITKQRGRKPFNFLHIKIDDGPFSEEIAHKYQNTALQI 312
            ||||:.:..:|.  .||:..||.:.     :.|.:|...  |....:..||.|....:.:|...:
Human    11 DILIVYSPDAEEWCQYLQTLFLSSR-----QVRSQKILT--HRLGPEASFSAEDLSLFLSTRCVV 68

  Fly   313 VILC---------PALLAL-------PHSFLMTQLSAIIRVEKVLAILLDVSEEKVKEMHKSALP 361
            |:|.         ||||.|       ||           ||.::|..:.| |||.:     ...|
Human    69 VLLSAELVQHFHKPALLPLLQRAFHPPH-----------RVVRLLCGVRD-SEEFL-----DFFP 116

  Fly   362 SYYKWRRCVVRDNDQVQISNI-LGIATD---------------ILGRALCQRPPCQDSSGGGGGG 410
            .:..|:.....|..:..::.: ..|:.|               ::..:..|..|...|.|
Human   117 DWAHWQELTCDDEPETYVAAVKKAISEDSGCDSVTDTEPEDEKVVSYSKQQNLPTVTSPG----- 176

  Fly   411 LSRSFSSCTEGFTVLPKKVKLGQNKVVALLAEPLEKNDTLKLQVEKSGE---LIELRNFKCRNPY 472
                     ....|.|.:::.|....|.::.. .:.:|.:..:.|.|.|   .:.: ..|..|.|
Human   177 ---------NLMVVQPDRIRCGAETTVYVIVR-CKLDDRVATEAEFSPEDSPSVRM-EAKVENEY 230

  Fly   473 TLQFNIPEACMEISTMIEIRIEKNNKSLGARPIKCESRLRELEQLLRIEDSPIEFMCHALGIGPV 537
            |:....|...   |..:.::|...:..:....|...:.:.|:..||....:|:||||.|..|.|.
Human   231 TISVKAPNLS---SGNVSLKIYSGDLVVCETVISYYTDMEEIGNLLSNAANPVEFMCQAFKIVPY 292

  Fly   538 ERDALDQHLLQCFQRNMPPN-FHLLSGPSERQPHFFTRLESSPEEYPTLLHFAARWGLNRLCIQL 601
            ..:.||:.|.:..:.|:|.: .||.......:....|  ....||.||||||||::||..|...|
Human   293 NTETLDKLLTESLKNNIPASGLHLFGINQLEEEDMMT--NQRDEELPTLLHFAAKYGLKNLTALL 355

  Fly   602 MECPGGDTACGVRNCAGRTPAELAEQEGHHKLAQNIVSFAEFHELTTMYHYFKGVTPPGESCPKP 666
            :.|||...|..|.|..|..|..:||:.|...|.|.|..:.|..::  :..:.|.....||
Human   356 LTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDM--LKSHIKEELMHGE----- 413

  Fly   667 SANVVIE--AHPVKAGKTNKPPKELPTAEYME--MSSGSERENTPEVRTKTETLAISNLNYISVE 727
            .|:.|.|  ||             |.|...|:  ::.|.:           |.|..|...::...
Human   414 EADAVYESMAH-------------LSTDLLMKCSLNPGCD-----------EDLYESMAAFVPAA 454

  Fly   728 TED---ENLQASVAE----------KKVESEKKLPEAGNQPGP---EKTTNELRINEPPYYQSKE 776
            |||   |.||||.:.          .|....:|..| ||..|.   |:....|...|..|:...:
Human   455 TEDLYVEMLQASTSNPIPGDGFSRATKDSMIRKFLE-GNSMGMTNLERDQCHLGQEEDVYHTVDD 518

  Fly   777 QNQQPKELKNQSKSLDEVDAAPLYQTDKFSQECSQLLENQLGNDYVLQPSNVPVAQDDGNYLFQP 841
            ......:|.::       ...|:.:.:..:....||.:|:   .|:.:.......:..||:....
Human   519 DEAFSVDLASR-------PPVPVPRPETTAPGAHQLPDNE---PYIFKVFAEKSQERPGNFYVSS 573

  Fly   842 SNRPVEEPLRLNRCTNRQPGYGTLKRSASDASAASHTRSNADDELAEIMHDFKNNVLSIRDVEVL 906
            .:.....|:|        |.....:.|..|..|...|....  :|..:....|..::::.:..:.
Human   574 ESIRKGPPVR--------PWRDRPQSSIYDPFAGMKTPGQR--QLITLQEQVKLGIVNVDEAVLH 628

  Fly   907 VERWK-HRNDVQQSFREKQDQIDQLRREYERIQEQVKSHLKRETPFERIKKFFLRSKTPGGNDSL 970
            .:.|: ::....:|||.:|:.:.:||....|.|.: |....::|..|...........|...:..
Human   629 FKEWQLNQKKRSESFRFQQENLKRLRDSITRRQRE-KQKSGKQTDLEITVPIRHSQHLPAKVEFG 692

  Fly   971 LDET---KSSIATSCSFKSAGGVSSSAGAGRPISSLSLQSVSSSSSSSGRLSTGSNCSGASLGDS 1032
            :.|:   ||.|......:.....:.|..             |::||:|.|.||.|..|.:    |
Human   693 VYESGPRKSVIPPRTELRRGDWKTDSTS-------------STASSTSNRSSTRSLLSVS----S 740

  Fly  1033 GTHSDHEDRRFPHCRMMDNYMVPPTPRPVFTPSSTPGDERHQIVFPSPMSSCQRLNT-------- 1089
            |...|:||...|.   :.....|..|:...||  |...||...|  .|.::.||..|
Human   741 GMEGDNEDNEVPE---VTRSRSPGPPQVDGTP--TMSLERPPRV--PPRAASQRPPTRETFHPPP 798

  Fly  1090 PTSPTG 1095
            |..|.|
Human   799 PVPPRG 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stumps	NP_731923.2	DBB	423..562	CDD:291229	34/142 (24%)
PIK3AP1	NP_689522.2	Necessary and sufficient to mediate inhibition of NF-kappa-B downstream of activated TLRs, may mediate interaction with MYD88 and TIRAP. /evidence=ECO:0000250	10..144		36/156 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..165		0/19 (0%)
		DBB	180..318	CDD:291229	34/142 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	527..547		1/26 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..590		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..679		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..805		34/132 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158197
Domainoid	1	1.000	40	1.000	Domainoid score	I12537
eggNOG	1	0.900	-	-		E1_28JV2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008315
OrthoInspector	1	1.000	-	-		otm41478
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16267
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5042
SonicParanoid	1	1.000	-	-		X6297
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.870