DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stumps and pik3ap1

DIOPT Version :9

Sequence 1:	NP_731923.2	Gene:	stumps / 41770	FlyBaseID:	FBgn0020299	Length:	1220	Species:	Drosophila melanogaster
Sequence 2:	XP_009305657.1	Gene:	pik3ap1 / 100002256	ZFINID:	ZDB-GENE-090313-250	Length:	837	Species:	Danio rerio

Alignment Length:	903	Identity:	192/903 - (21%)
Similarity:	320/903 - (35%)	Gaps:	269/903 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 LLALPHSFLMTQLSAIIRVEKVLAILLDVSEEKVKEMHKSALPSYY-KWRRCVVRDNDQVQISNI 382
            ||..||              ||:|.|..||||.:     |....|: :||:....|..||.:|.|
Zfish    81 LLHPPH--------------KVVAFLCGVSEELM-----SGYFEYWEQWRKIFSEDEPQVYVSTI 126

  Fly   383 LGIATDILGRAL---CQ-------RPPCQDSSGGGGGGLSRSFSSCTEGFTVLP-----KKVKLG 432
            .....:  |..|   ||       ..|.:|..       ...||.      :||     .:.:|.
Zfish   127 RESIDE--GSVLQHQCQNTYEIEPEEPLEDLP-------LPDFSE------ILPLPDELNEHQLN 176

  Fly   433 QNKVVALLAEPLE-KNDTLKLQVEK------SG-ELIELRNFKCRN--------------PYTLQ 475
            .::|.:.|...|. .||.:.|.|:.      || .:..:...||.:              |..|.
Zfish   177 GDEVCSFLQTSLNTSNDQICLSVQPDRILCGSGVSIFVMLVQKCEDEDSVEVEFHSQQSPPLRLP 241

  Fly   476 FNIPEACMEISTM---------IEIRIEKNNKSLGARPIKCESRLRELEQLLRIEDSPIEFMCHA 531
            ..:...|  |.|:         :.:.:.||...|.:..:...:.:.|:.:.|:....|::|||.|
Zfish   242 GTLVNQC--IVTVQSPDMPAGEVSLTVYKNQSVLCSSTVTYYTEMEEICRYLKKATDPVQFMCQA 304

  Fly   532 LGIGPVERDALDQHLLQCFQRNMPPNFHLLSGPSERQPHFFTRLESSPEEYPTLLHFAARWGLNR 596
            ..|....:::||..|....:..||.|...:.|.|:.:.:  |.......|.||||||:|::||.:
Zfish   305 FDITSKLQESLDNLLATSLEERMPVNGLQVFGISQIEEN--TAANHRDVELPTLLHFSAKYGLKK 367

  Fly   597 LCIQLMECPGGDTACGVRNCAGRTPAELAEQEGHHKLAQNIVSFAEFHELTTMYHYFKGVTPPGE 661
            |...||.|||...|..|.|..|..|.:|||:.|...|.|.:..:.|..:|
Zfish   368 LTSLLMRCPGAMQAYSVMNKDGDYPNKLAEKSGFSDLRQFMDEYVETVDL--------------- 417

  Fly   662 SCPKPSANVVIEAHPVKAGKTNKPPKELPTAEYMEMSSGSERENTPEVRTKTETLAISNLNYISV 726
                      ::.|.                        .|.:|.||.....|.:..::.|:||
Zfish   418 ----------VKTHI------------------------EESQNAPESEDIYEDMLRASQNFIS- 447

  Fly   727 ETEDENLQASVAEKKVESEKKLPEAGNQPGPEKTTNELRINEPPY--YQSKEQNQQPKELKNQSK 789
            |.::||:..|:.:...|...:|..|.....||:...:. ...||.  :||.:.|       :.:.
Zfish   448 EFDNENIYESMVKLNPEMGDELESALGDSNPERMLRKF-FEGPPEKGFQSMKHN-------STNG 504

  Fly   790 SLDEVDAAPLY-------------QTDKFSQECSQLLENQL---GNDYVL--------QPSNVPV 830
            .|.|:|....:             :.|.::..|.:.:.:.:   .:..|:        :|:.:|.
Zfish   505 GLPEMDDEDYHDMGVKVDVYGDFEEEDPYNPCCPEQIYDTVEPHSSPEVMNRPPAPIPRPAKLPE 569

  Fly   831 AQDDGNY----------LFQPSNRPVEE----PLRLNRCTNRQPGYGTLKRSASDASAASH---- 877
            .:::..|          |:..|.||..:    |:||.|                |...:||
Zfish   570 PEENTTYISKVFCPKDPLYSVSQRPERDPSIAPVRLVR----------------DRDMSSHHDPF 618

  Fly   878 --TRSNADDELAEIMHDFKNNVLSIRDVEVLVERWKHRNDVQ-QSFREKQDQIDQLRREYERIQE 939
              .::....:|..:....|...|::.:.....:.|:...|.: :|.|.:|:.:.:||....|
Zfish   619 AGMKTPGQRQLISLQERVKVGELTVEEAVQEFKAWQFDQDKRWRSLRFQQENLHRLRESITR--- 680

  Fly   940 QVKSHLKRETPFERIKKFFLRSKTPGGNDSLLDETKSSIATSCSFKSAGGVSSSAGAGRPISSLS 1004
                                |.|..|.|:.::   .:.:.|:..:.|...|:.|.....|.:.:.
Zfish   681 --------------------RCKDKGTNELMI---TAPMQTNTQWGSQMNVNCSVYEPTPRTVVQ 722

  Fly  1005 LQSV---------------SSSSSSSGRLSTGSNCSGASLGDSGTHSDHEDRRFPHCRMMDNYMV 1054
            ..||               |:|||||.|||..|..|.:    ||...:.|....|         :
Zfish   723 PPSVNRAPQRGSWQTGSTSSTSSSSSHRLSIQSTVSNS----SGVDGEEEPPDIP---------L 774

  Fly  1055 PPTP-RPVF--TPSSTPGDERHQIVFPSPMSSCQR-LNTPTSPTGSEHYQMFPSNIPV 1108
            ||.| |||.  .|...|.....:::..||....:| ::.|:.|....     |:..|:
Zfish   775 PPRPLRPVVDSPPILPPPRVPPRVIERSPEILNERYVSNPSRPVPQN-----PAQRPI 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stumps	NP_731923.2	DBB	423..562	CDD:291229	36/174 (21%)
pik3ap1	XP_009305657.1	DBB	198..336	CDD:291229	27/139 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594078
Domainoid	1	1.000	58	1.000	Domainoid score	I10798
eggNOG	1	0.900	-	-		E1_28JV2
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008315
OrthoInspector	1	1.000	-	-		oto39052
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16267
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6297
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930