DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7987 and ZNF142

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	NP_001353219.1	Gene:	ZNF142 / 7701	HGNCID:	12927	Length:	1887	Species:	Homo sapiens

Alignment Length:	1407	Identity:	286/1407 - (20%)
Similarity:	432/1407 - (30%)	Gaps:	373/1407 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DDAQVVTEE--VITDDWVQHQGAERVEIAAEQIAGISSSQELLDMEQDEYTALRPYPCDFCSRRF 149
            |.|.:.||.  ::.:.....:|...:||..|.:||..:.....:........:..|.|:.|.:.|
Human    48 DPAPIPTEPGCLLVEATATEEGPGNMEIIVETVAGTLTPGAPGETPGVLVKVVEVYFCERCEQSF 112

  Fly   150 RKKATLNNHMLAH-----------------------------QNDRPHL----CKLCGARFSRRA 181
            .:...|..|..:.                             |...|.:    |.:|...|::..
Human   113 AEPTLLALHQCSETHIQPVQGLSSPPCSVELPPSNPTLPGPLQGQSPPVSPLSCPVCRQEFAQPQ 177

  Fly   182 ELISHFKAHAEAQDAADAEAAAAAADSSSAIKFEH---QTQRQLDDHYYEQEWP-LFQHQQEQEN 242
            .|.||||.|....|......:.....:......:|   ||.|.:......:..| ||..||..|.
Human   178 ALKSHFKIHRGTPDTFSCPESGCVFSAEDRKGLQHHLRQTHRAVPVPCSFRGCPLLFGSQQGMEL 242

  Fly   243 AQQ---------------NV-----HQQ-HQIVEEGGIQLVASYPDTVAQPA--------APSRG 278
            .:|               ||     ||: |....:|.:..|...|.....||        .||:.
Human   243 HRQAHYPFHCSHCSFIGSNVKLFRQHQRSHGAGTQGELSAVQGLPSQELLPAPKLPPGEREPSQE 307

  Fly   279 RISRLK----------PKEESSQFIVISDKSVEDSRPYMEPEPAQPVVTTSEFIAVEPPPQPNFP 333
            ..:.|.          .|||.|.....|.|:|:..:.....|  ..||:.:|.:
Human   308 AGTPLPGQETAEEENVEKEEKSDTQKDSQKAVDKGQGAQRLE--GDVVSGTESL----------- 359

  Fly   334 VLDHSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECNQCQEMFWDNSSLQEH------QKTHQ 392
                .|..:|.:|...|.:...||.|...|..|...:|..||:.|...|.|:.|      :|.|.
Human   360 ----FKTHMCPECKRCFKKRTHLVEHLHLHFPDPSLQCPNCQKFFTSKSKLKTHLLRELGEKAHH 420

  Fly   393 FE-------ESNSEYDPASAEESGSESEADEQLYGEFY-CNECGISFHRQDLLRRHAKMH----- 444
            ..       |.|     |......|..|.....|.:.| |..|...|.....|:.|.|.|
Human   421 CPLCHYSAVERN-----ALNRHMASMHEDISNFYSDTYACPVCREEFRLSQALKEHLKSHTAAAA 480

  Fly   445 ------------CK---PSDQAAVGSNSDVTAGGDVELAKDSSGHCCNTCGKSFPSALEMLAHAE 494
                        |.   |..:|.:....:......||....|       |...|.:|..|.||.:
Human   481 AEPLPLRCFQEGCSYAAPDRKAFIKHLKETHGVRAVECRHHS-------CPMLFATAEAMEAHHK 538

  Fly   495 IHARFPPFKCVLCGISFYEEQAIKRHLHTRHP--SELNANSCVLCGKECRDRKALIKHAWD-HSR 556
            .|.   .|.|..|..:...:...::|....||  .||.   |..|.....:..|...|... |:.
Human   539 SHY---AFHCPHCDFACSNKHLFRKHKKQGHPGSEELR---CTFCPFATFNPVAYQDHVGKMHAH 597

  Fly   557 EKCHSCSKCGKNFHNKARLKRHMASHR-DKSVVCEVCQEEFPDGRTLSNHRHSHSTTTPGKLFPC 620
            ||.|.|.:|.....:|..|.|||..|. :|...||:|.....|...||.|..:||.|   |.:.|
Human   598 EKIHQCPECNFATAHKRVLIRHMLLHTGEKPHKCELCDFTCRDVSYLSKHMLTHSNT---KDYMC 659

  Fly   621 LECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQ 685
            .|||.....:...::|:|.|.|:..|.|..|.........|..|:..|.| |...|.||..|..:
Human   660 TECGYVTKWKHYLRVHMRKHAGDLRYQCNQCSYRCHRADQLSSHKLRHQG-KSLMCEVCAFACKR 723

  Fly   686 RVVLREHIRS-HHSGLDVARNTYHCTVCSEDLASSNDLIQHLIQHSDSNTAKQRQPVTGPRKYKR 749
            :..|::|:.| ||.|....  .|.|..||..                   ::.:|.|......|.
Human   724 KYELQKHMASQHHPGTPAP--LYPCHYCSYQ-------------------SRHKQAVLSHENCKH 767

  Fly   750 RRKLQPH-------------EIAHMRAANKHVNGDEEEAIGEGDAEECASDIDFCDFDVENVDDI 801
            .|..:.|             .:.|.|.|:.:|.||:            |..:.:.
Human   768 TRLREFHCALCDYRTFSNTTLLFHKRKAHGYVPGDQ------------AWQLRYA---------- 810

  Fly   802 FDMAESPKKEKRKRGSAATKADAKPVTNGKAAK---PAQDKGK-AKPRYDSTSSQQSDRLWEEKF 862
                 |.:.|...:| .....|::| :|..:|:   |..:.|. ..|..|....:.|:.:
Human   811 -----SQEPEGAMQG-PTPPPDSEP-SNQLSARPEGPGHEPGTVVDPSLDQALPEMSEEV----- 863

  Fly   863 LHDSQVALFQIDSLVVVNDTHLQPASSAVSANIPNTRGGSKQQGKVQAKSVEGAENLNSSA---- 923
                              :|..|..|.|...   ...|||....:|:    ||:..|:..|
Human   864 ------------------NTGRQEGSEAPHG---GDLGGSPSPAEVE----EGSCTLHLEALGVE 903

  Fly   924 --TTSDTTFSASTSTASTRSRKRAATTKTASKAPPASNSRPRMIHTEKAKVTKGVGGDSTSSSAK 986
              :.::......|.||....|             |.....|..:...:....:|:|....|:...
Human   904 LESVTEPPLEEVTETAPMEFR-------------PLGLEGPDGLEGPELSSFEGIGTSDLSAEEN 955

  Fly   987 KTRSKTYISRTESHNLSLDKSRSSASNMVDDYEIISPATH---PPNQISSSPLHIKQEQEQQQ-- 1046
            ....|. :|...::..||::   :.:|.|..::...||..   ||...|.|.|...:.|:::|
Human   956 PLLEKP-VSEPSTNPPSLEE---APNNWVGTFKTTPPAETAPLPPLPESESLLKALRRQDKEQAE 1016

  Fly  1047 ------RVQLM-----------------------------------------------------Y 1052
                  |||::                                                     .
Human  1017 ALVLEGRVQMVVIQGEGRAFRCPHCPFITRREKALNLHSRTGCQGRREPLLCPECGASFKQQRGL 1081

  Fly  1053 DDNLLIDAALLREKTYEKFNPSIVNDLEEILRSPLKHERNSRLRFTSESSTTPQYLHEEEQNLIK 1117
            ..:||....:|..|......|.....|:.:|......|       .:||...|....|.|..|.|
Human  1082 STHLLKKCPVLLRKNKGLPRPDSPIPLQPVLPGTQASE-------DTESGKPPPASQEAELLLPK 1139

  Fly  1118 IEPTS-PDLREMLEGQQRVIAHSGS-TPSSSSSARTSRHLRQI--------TANGARAGSKRTTG 1172
            ..|.. |  ||..|.::.:...||| .|.:.:|..|....:..        .::...|..|....
Human  1140 DAPLELP--REPEETEEPLATVSGSPVPPAGNSLPTEAPKKHCFDPVPPAGNSSPTEAPKKHHLD 1202

  Fly  1173 GVASKTSASPGVVAKKSNTATKVSSSSSSSYLSYGVDSYNVNVPASANNGDVGSGFFSISEV--- 1234
            .|....::||....||..........:|..:|...:.|...:|......|..|.|.....:.
Human  1203 PVPPAGNSSPTEALKKHRFEQGKFHCNSCPFLCSRLSSITSHVAEGCRGGRGGGGKRGTPQTQPD 1267

  Fly  1235 VSAADAADAAAKAAAAGKS-----------ERKTRSFECEMC 1265
            ||.....|:|.....:.:|           ::|...|.|..|
Human  1268 VSPLSNGDSAPPKNGSTESSSGDGDTVLVQKQKGARFSCPTC 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368	5/19 (26%)
		C2H2 Zn finger	170..186	CDD:275368	4/15 (27%)
		COG5048	326..734	CDD:227381	111/446 (25%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	8/25 (32%)
		C2H2 Zn finger	424..444	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		C2H2 Zn finger	504..523	CDD:275368	3/18 (17%)
		C2H2 Zn finger	534..554	CDD:275370	4/20 (20%)
		C2H2 Zn finger	562..582	CDD:275370	7/19 (37%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		C2H2 Zn finger	620..640	CDD:275368	6/19 (32%)
		C2H2 Zn finger	648..668	CDD:275368	4/19 (21%)
		zf-H2C2_2	661..685	CDD:290200	9/23 (39%)
		C2H2 Zn finger	676..696	CDD:275368	7/20 (35%)
		C2H2 Zn finger	709..726	CDD:275371	3/16 (19%)
		Hph	921..>1017	CDD:290417	16/101 (16%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	421..438	CDD:275368	3/21 (14%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		C2H2 Zn finger	545..566	CDD:275368	3/20 (15%)
		C2H2 Zn finger	574..595	CDD:275368	4/20 (20%)
		zf-H2C2_5	601..625	CDD:404746	9/23 (39%)
		C2H2 Zn finger	603..623	CDD:275368	7/19 (37%)
		C2H2 Zn finger	631..651	CDD:275368	7/19 (37%)
		C2H2 Zn finger	659..679	CDD:275368	6/19 (32%)
		C2H2 Zn finger	687..707	CDD:275368	4/19 (21%)
		C2H2 Zn finger	714..731	CDD:275368	5/16 (31%)
		PHA03247	928..>1219	CDD:223021	54/303 (18%)
		C2H2 Zn finger	1306..1353	CDD:275368	2/4 (50%)
		C2H2 Zn finger	1373..1394	CDD:275368
		C2H2 Zn finger	1402..1422	CDD:275368
		C2H2 Zn finger	1430..1451	CDD:275368
		C2H2 Zn finger	1626..1646	CDD:275368
		C2H2 Zn finger	1654..1674	CDD:275368
		C2H2 Zn finger	1682..1702	CDD:275368
		C2H2 Zn finger	1710..1730	CDD:275368
		zf-H2C2_2	1723..1747	CDD:404364
		C2H2 Zn finger	1738..1759	CDD:275368
		C2H2 Zn finger	1767..1787	CDD:275368
		C2H2 Zn finger	1795..1815	CDD:275368
		C2H2 Zn finger	1823..1843	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100