DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7987 and WIZ

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	NP_001358518.1	Gene:	WIZ / 58525	HGNCID:	30917	Length:	1889	Species:	Homo sapiens

Alignment Length:	1438	Identity:	251/1438 - (17%)
Similarity:	415/1438 - (28%)	Gaps:	597/1438 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 GARFSRRAE---LISHFKAHAEAQDAADAEAAAAAADSSSAIKFEHQ--TQRQLDDHYYEQEWPL 233
            |....||.|   ::...|.|||.:.:.               :|.|.  ..|.|:.|  .|..|.
Human   136 GILSERRFEDSVIVRTMKPHAELEGSR---------------RFLHHRGEPRLLEKH--AQGRPR 183

  Fly   234 FQHQQEQENAQQNVHQQHQIVEEGGIQLVASYPDTVAQP-------------------------- 272
            |...|:::             |:|..|....:.|..|||
Human   184 FDWLQDED-------------EQGSPQDAGLHLDLPAQPPPLAPFRRVFVPVEDTPKTLDMAVVG 235

  Fly   273 -----------AAPSRGRISRLKPKEESSQFIVISDKSVEDSRPYMEPEPAQPVV-----TTSEF 321
                       |.||...:.....:..:..:.|.|:.|||..:|.:.|....|.:     ..:|.
Human   236 GREDLEDLEGLAQPSEWGLPTSASEVATQTWTVNSEASVERLQPLLPPIRTGPYLCELLEEVAEG 300

  Fly   322 IAVEPPPQPNFPVLDHSKPFVCQQCGLAFAREKALVSHTKNHR--------VD-SPFECNQCQEM 377
            :|.....:...|.:     |.|.:|.:.|.:::.|:.|...||        .| :|..|.:|...
Human   301 VASPDEDEDEEPAV-----FPCIECSIYFKQKEHLLEHMSQHRRAPGQEPPADLAPLACGECGWA 360

  Fly   378 FWDNSSLQEHQKTHQFEESNSEYDPASAEESGSESEADEQLYGE------FYCNECGISFHRQDL 436
            |.|.::|::|::.||          ||.|:...|.:..:|:.|:      ..|.:|....:....
Human   361 FADPTALEQHRQLHQ----------ASREKIIEEIQKLKQVPGDEGREARLQCPKCVFGTNSSRA 415

  Fly   437 LRRHAKMHCKPSDQAAVGSNSDVTAGGDVELAKDSSGHCCNTCGKSFPSALEMLAHAEIHARFPP 501
            ..:|||:|.:...    |..:....||       |||     .|...|.|..:|        :.|
Human   416 YVQHAKLHMREPP----GQTTKEPFGG-------SSG-----AGSPSPEASALL--------YQP 456

  Fly   502 F-------KCVLCGISFYEEQAIKRHLHT--RHPSELNANSCVLCGKECRDRKALIKHAWDHSRE 557
            :       .||.||.....|..::.|:..  .||.                        |:...|
Human   457 YGAAVGLSACVFCGFPAPSESLLREHVRLVHAHPH------------------------WEEDGE 497

  Fly   558 --------------KCHSC------SKCGKNFHNKARLKRHMASHRDKSVVC-EVCQE----EFP 597
                          ..|:|      ...||...:.|.:.|...:..|.|:.. ..||:    :||
Human   498 AYEEDPASQPGTSQDAHACFPDTAVDYFGKAEPSLAPMWRENPAGYDPSLAFGPGCQQLSIRDFP 562

  Fly   598 DGRTLSNHRHSHSTTTPGKL-FPCLECGKTFG---SRSSQQIHVRIHTGER-------------- 644
            ..:.|   .|.......|:| ||.......:.   .|:...:|.: ..|||
Human   563 LSKPL---LHGTGQRPLGRLAFPSTLASTPYSLQLGRNKSTVHPQ-GLGERRRPWSEEEEEEEEE 623

  Fly   645 ---------------------------PYGCRYCWKAFAD------------------------- 657
                                       |.......:||.:
Human   624 EDVVLTSEMDFSPENGVFSPLATPSLIPQAALELKQAFREALQAVEATQGQQQQLRGMVPIVLVA 688

  Fly   658 --------------------------------------GGTL-------------RKHERIHTGE 671
                                                  ||.|             .|||.
Human   689 KLGPQVMAAARVPPRLQPEELGLAGAHPLDFLLLDAPLGGPLGLDTLLDGDPAMALKHEE----- 748

  Fly   672 KPYACSVCPRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSEDLASSNDLIQHLIQHSDSNTAK 736
              ..|..||..|:..:.|..|:|.|.:.:.|:.|                 ::|.|...:....:
Human   749 --RKCPYCPDRFHNGIGLANHVRGHLNRVGVSYN-----------------VRHFISAEEVKAIE 794

  Fly   737 QRQPVTGPRKYKRRRKLQPHEIAHMRAANKHVNGDEEEAIGEGDAEECASDIDFC---------- 791
            :|  .:..:|.|:.....|...:.||.                         |||
Human   795 RR--FSFQKKKKKVANFDPGTFSLMRC-------------------------DFCGAGFDTRAGL 832

  Fly   792 ---------DFDVENVDDIFDMAESPKKEKRKRGSAATKADAKP---------------VTNGKA 832
                     ||.:.|    :::..||....::  ..||.|..:|               :|:.:.
Human   833 SSHARAHLRDFGITN----WELTVSPINILQE--LLATSAAEQPPSPLGREPGGPPGSFLTSRRP 891

  Fly   833 AKP---------AQDKGKAKPRY-DSTSSQQSDRLWEEKFLHDSQVALFQID---------SLVV 878
            ..|         |:|.|   |.| |...|:::              |:..:|         ||.|
Human   892 RLPLTVPFPPTWAEDPG---PAYGDGLGSEEN--------------AMVAMDLGSPSLPKKSLPV 939

  Fly   879 VN--DTHLQPASSAVSANIPNTRGGSKQQ-GKVQAKSV----------EGAENLNSSATTSDTTF 930
            ..  :......||.|:|.:|:   ||||: ..::|:|:          |..:.|:|.|.:.....
Human   940 PGALEQVASRLSSKVAAEVPH---GSKQELQDLKAQSLTTCEVCGACFETRKGLSSHARSHLRQL 1001

  Fly   931 SASTSTASTR-------------------------SRKRAATTKTASKAP-------------PA 957
            ..:.|.:|..                         ::|.::..:..:.||             ||
Human  1002 GVAESESSGAPIDLLYELVKQKGLPDAHLGLPPGLAKKSSSLKEVVAGAPRPGLLSLAKPLDAPA 1066

  Fly   958 SNSRPRMIHTEKAKVTKGVGGDSTSSSAKKTRSKTYISRT------ESHNLSLDKSRSSASNMVD 1016
            .|   :.|.:......||:|...:|...|||......|.|      :|..|||....:
Human  1067 VN---KAIKSPPGFSAKGLGHPPSSPLLKKTPLALAGSPTPKNPEDKSPQLSLSPRPA------- 1121

  Fly  1017 DYEIISPATHPPNQISSSPLHIKQEQEQQQRVQLMYDDNLLIDAALLREKTYEKFNPSIVNDLEE 1081
                 ||....|......||::..:.:..:.:     |..|..|.....|           .|..
Human  1122 -----SPKAQWPQSEDEGPLNLTLDSDGGREL-----DCQLCGAWFETRK-----------GLSS 1165

  Fly  1082 ILRSPLKHERNSRLRFTSESSTTP-QYLHEEEQNLIKIEPTSPDLREMLEGQQRVIAHSGSTPSS 1145
            ..|:.|:|...|    ..::..:| ..||    .||:.:    .::..|..::..:||.|..|.:
Human  1166 HARAHLRHLGVS----DPDAKGSPIDVLH----GLIRRD----GVQIRLPPRRGALAHPGRPPPT 1218

  Fly  1146 SSSARTSRHLRQITANGARAGSKRTTGGVASKTSASPGVVAKKSNTATKVSSSSSSSYLSYGVDS 1210
            |                            |:.:...|...|||:    |:.::..:|  .:|  .
Human  1219 S----------------------------AALSLLPPPPPAKKA----KLKAAGMAS--PWG--K 1247

  Fly  1211 YNVNVPASANNGDVGSGFFSISEVVSAADAADAAAKAAAAGKSERKTRSFECEMCSAIFYDRTQL 1275
            .:::..|:|       |.|..|:|..:.....:..:.|         |...||.|...|.:|..|
Human  1248 QDLSAAAAA-------GIFWASDVEPSPLNLSSGPEPA---------RDIRCEFCGEFFENRKGL 1296

  Fly  1276 LEHVHIHI 1283
            ..|...|:
Human  1297 SSHARSHL 1304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368
		C2H2 Zn finger	170..186	CDD:275368	4/14 (29%)
		COG5048	326..734	CDD:227381	96/577 (17%)
		C2H2 Zn finger	343..363	CDD:275368	5/19 (26%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	476..496	CDD:275368	4/19 (21%)
		C2H2 Zn finger	504..523	CDD:275368	6/18 (33%)
		C2H2 Zn finger	534..554	CDD:275370	1/19 (5%)
		C2H2 Zn finger	562..582	CDD:275370	5/25 (20%)
		C2H2 Zn finger	589..609	CDD:275368	6/24 (25%)
		C2H2 Zn finger	620..640	CDD:275368	2/22 (9%)
		C2H2 Zn finger	648..668	CDD:275368	8/95 (8%)
		zf-H2C2_2	661..685	CDD:290200	8/36 (22%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	709..726	CDD:275371	0/16 (0%)
		Hph	921..>1017	CDD:290417	24/139 (17%)
WIZ	NP_001358518.1	C2H2 Zn finger	317..337	CDD:275368	5/19 (26%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		C2H2 Zn finger	403..423	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8416
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950