DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7987 and znf711

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	NP_001352539.1	Gene:	znf711 / 562505	ZFINID:	ZDB-GENE-081107-49	Length:	765	Species:	Danio rerio

Alignment Length:	757	Identity:	165/757 - (21%)
Similarity:	264/757 - (34%)	Gaps:	171/757 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SEVDILESDGGAGASGEDLDHVAAENLIFMARDGQLSEIMAA--------NEAGRTVLVTADGTT 78
            :||.|.|:..|..    ||......:.:|:|      |:|:.        |.....|:||...|.
Zfish    94 AEVAIQEALSGTA----DLIEETVPDQVFVA------ELMSPHIQSPLDHNLVSAEVMVTDADTV 148

  Fly    79 VAYAESFDDDAQVVTEEVITDDWVQHQGAERVEIAAEQIAGISSSQELLDMEQDEYTALRPYPCD 143
            :...::...|..:..::  .::.|:....:.:.|:.:::.|      .||:|.   |:|
Zfish   149 IDSHDTLQSDVTIKADD--DEEDVKSTSEDYLMISLDEVGG------KLDIED---TSL------ 196

  Fly   144 FCSRRFRKKATLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAADS 208
                  :..|.:.......:.|          .||.....:..|||..:    .|.|..:.....
Zfish   197 ------KISADVGQDDDGSKED----------EFSSEVIKVYIFKADGD----EDVEIGSTEVVE 241

  Fly   209 SSAIKFEHQTQRQLDDHYYEQEWPLFQ-----HQQEQENAQQNVHQQHQIV----EEGGIQLVAS 264
            .|.....|.....:......:|..::.     :|::..|..:...|.:..|    ||......|.
Zfish   242 ESDFPGRHTVMESVGSGRLPREKMVYMAVKDANQEDDLNCSEMTDQVYMEVIVGEEEAPAITEAQ 306

  Fly   265 YPDTVAQ----PAAPSRGRISRLKPKE-ESSQFIVISDKSVEDSRPYM---------EPEPAQPV 315
            ..|:...    |||.:....|.|:.|. .::.::.|:| |:..||...         |....|..
Zfish   307 MEDSPVNKTIVPAAWATAYGSSLESKNGAATPYLQITD-SISTSRALKQKIKKRRRGETRQCQTG 370

  Fly   316 VTTSEFIAVEPPPQPNFPVLDHSKPFVCQQCGLAFAREKALVSHTKN---HRVDSPFECNQCQEM 377
            ::.|..|..:..|...:|         |..||..|.....|..|.||   |.....::|..|:
Zfish   371 MSFSVIIGPDGQPLTVYP---------CHICGKKFKSRGFLKRHMKNHPDHMFKKKYQCTDCE-- 424

  Fly   378 FWDNS--SLQEHQKTH----------QFEESNSEYDPASAEESGSESEADEQ--LYGEFYCNECG 428
            |..|.  |...|.::|          ::.|....|..||...|......|::  |:   .|..|.
Zfish   425 FTTNKKVSFHNHLESHKLIIKNEKIPEYTEYTRRYHEASPLSSNKLILRDKEPKLH---KCKYCE 486

  Fly   429 ISFHRQDLLRRH-AKMHCKPSDQAAVGSNSDVTAGGDVELAKDSSGHCCNTCGKSFPSALEMLAH 492
            .....|.||.|| ..:|.|                        :..|.|..|.|.|....|:..|
Zfish   487 YETAEQGLLNRHLLAVHSK------------------------NFAHVCVECAKGFRHPSELKKH 527

  Fly   493 AEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPSELNANSCVLCGKECRDRKALIKHA---WDH 554
            ...|....||.|..|..|..::..:|.|:.::|.::| ...|..|.:...|.|.|.:||   ..|
Zfish   528 MRTHTGEKPFHCQHCEFSCADQSNLKTHIKSKHGTDL-PFKCGHCPQAFADDKELQRHAEIFQGH 591

  Fly   555 SREKC--------------------------HSCSKCGKNFHNKARLKRHMASHRDKSV-VCEVC 592
            ...:|                          |.|..|.|.||..:.||:|..:|:...| .|..|
Zfish   592 KTHQCPHCEHKSTNSSDLKRHIISVHTKDFPHKCDVCEKGFHRPSELKKHSETHKGNKVHQCRHC 656

  Fly   593 QEEFPDGRTLSNHRHS-HSTTTPGKLFPCLECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFA 656
            ..:..|..|||.|..| |:...|   |.|..|.:.|..::..:.|::.|:|.:.|.|:||.....
Zfish   657 DFKTLDPFTLSRHILSVHTKDLP---FKCKRCKRGFRHQNELKKHMKTHSGRKVYQCQYCEYNTT 718

  Fly   657 DGGTLRKHE-RIHTGEKPYACSVCPRAFNQRVVLREHIRSHH 697
            |....::|. .|||.:.|:.|..|.:.|.:.....:||..||
Zfish   719 DASGFKRHVISIHTKDYPHRCDYCKKGFRRPSEKNQHIMRHH 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368	1/19 (5%)
		C2H2 Zn finger	170..186	CDD:275368	2/15 (13%)
		COG5048	326..734	CDD:227381	105/422 (25%)
		C2H2 Zn finger	343..363	CDD:275368	8/22 (36%)
		C2H2 Zn finger	371..391	CDD:275368	6/21 (29%)
		C2H2 Zn finger	424..444	CDD:275368	7/20 (35%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		C2H2 Zn finger	504..523	CDD:275368	5/18 (28%)
		C2H2 Zn finger	534..554	CDD:275370	7/22 (32%)
		C2H2 Zn finger	562..582	CDD:275370	8/19 (42%)
		C2H2 Zn finger	589..609	CDD:275368	8/20 (40%)
		C2H2 Zn finger	620..640	CDD:275368	4/19 (21%)
		C2H2 Zn finger	648..668	CDD:275368	5/20 (25%)
		zf-H2C2_2	661..685	CDD:290200	8/24 (33%)
		C2H2 Zn finger	676..696	CDD:275368	5/19 (26%)
		C2H2 Zn finger	709..726	CDD:275371
		Hph	921..>1017	CDD:290417
znf711	NP_001352539.1	Zfx_Zfy_act	64..368	CDD:309717	57/321 (18%)
		COG5048	385..763	CDD:227381	104/418 (25%)
		C2H2 Zn finger	389..409	CDD:275368	7/19 (37%)
		C2H2 Zn finger	482..503	CDD:275368	7/20 (35%)
		C2H2 Zn finger	511..531	CDD:275368	6/19 (32%)
		C2H2 Zn finger	539..560	CDD:275368	5/20 (25%)
		C2H2 Zn finger	568..584	CDD:275368	5/15 (33%)
		C2H2 Zn finger	596..617	CDD:275368	1/20 (5%)
		C2H2 Zn finger	625..645	CDD:275368	8/19 (42%)
		C2H2 Zn finger	682..702	CDD:275368	4/19 (21%)
		C2H2 Zn finger	710..731	CDD:275368	5/20 (25%)
		C2H2 Zn finger	739..759	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100