DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7987 and dati

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	NP_001245421.1	Gene:	dati / 43789	FlyBaseID:	FBgn0262636	Length:	1150	Species:	Drosophila melanogaster

Alignment Length:	923	Identity:	174/923 - (18%)
Similarity:	308/923 - (33%)	Gaps:	282/923 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 LRRHAKMHCKPSDQAAVGSNSDVTAGGDVELAKDSSGHCCNTCGKSFPSALEMLAHAEIHARFPP 501
            |:.|   .|||.....||| |::.||                 .:|.|:.:..
  Fly   302 LQTH---QCKPMSPGTVGS-SNLGAG-----------------RRSAPTTISK------------ 333

  Fly   502 FKCVLCGISFYEEQAIKRHLHT----------RHPSELNANSCVLCGKECRDRKALIKHAWDHSR 556
                    :|.:.|...:|..|          ::.::..||...|.........|:.    :.:.
  Fly   334 --------TFSQGQQSPQHSTTPSGGSTTPDIKYNNDKMANEIQLQLSRSSSAAAIS----ERTL 386

  Fly   557 EKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRT-LSNHRHSHSTTTPGKLFP- 619
            |:|.|..:         ||..|      ||.:.:: |::.|  |. |..|..:.|....|.:.|
  Fly   387 EECWSTLQ---------RLFMH------KSAMQQI-QQQIP--RVGLGTHGVTGSANLGGSITPS 433

  Fly   620 -------CLECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACS 677
                   |.:|.|:|.|......|:|:||||:||.|.||.:.|.....:::|.|:||||:||.|.
  Fly   434 SDTKPHQCQQCMKSFSSNHQLVQHIRVHTGEKPYKCSYCDRRFKQLSHVQQHTRLHTGERPYKCH 498

  Fly   678 V--CPRAFNQRVVLREHIRSHHSGLDVARN-TYHCTVCSEDLASSNDLIQHLIQHSDSNTAKQRQ 739
            :  |.|||.|...|::|:|:|.:.::.|:| .:||.:|.:..|:.:.|..|        |:|:.|
  Fly   499 LPDCGRAFIQLSNLQQHLRNHDAQVERAKNRPFHCNICGKGFATESSLRTH--------TSKELQ 555

  Fly   740 -----------PVTGPR---------------------KYKRRRKLQP---------HEIAHMRA 763
                       .:.||.                     |:..:.|..|         .|:..:..
  Fly   556 LHLGVLQQHAALIGGPNATSCPVCHKLFLGTEALVDHMKHVHKEKSPPPGGSASSQFSELNQIVT 620

  Fly   764 ANKHVNGDEEEAIGEGDAEECASDIDFCDFDVEN--VDDIFDMAESPK-----------KEKRKR 815
            .|.:..|...|.|    |.:|.::.:.....|.:  :|.......:..           .|...|
  Fly   621 GNGNGTGSSNEQI----ATQCTTESNSHQATVGSSLIDSFLGKRRTANHPCPVCGKHYVNEGSLR 681

  Fly   816 GSAATKADAKPVTNGKAAKPA----------------QDKGKAKPRYDSTSSQQSDRLWEEKFLH 864
            ...|..|:...:||.....|.                .:..:..|::...:.....|...|:...
  Fly   682 KHLACHAENSQLTNSLRMWPCSVCQAVFTHENGLLTHMESMRMDPKHQFAAQYVLSRAAAEQRER 746

  Fly   865 DSQVALFQIDSLVVVNDTHLQPASSAVSANIPNTRGGSKQQGKVQAKSVEGAENLNSSATTSD-- 927
            :|.:|:....|........:..|.:.:.....|:.|.:.:.....|.|...:....||:||||
  Fly   747 ESLLAVTLAASSGASTRIGIADAGNVLPTGAHNSDGSNSKCPSPSANSECSSNGRLSSSTTSDQD 811

  Fly   928 ----------------TTFSASTSTASTRSRKRAATTKTASKAPPASN-----------SRPRMI 965
                            ...|::.:..:..|...|::.|.|....|.:.           :|..::
  Fly   812 QDIDHGLSENENSNQNNIGSSTNNNNNCTSNNNASSHKMAELRLPGTGQYTMDAELHVANRMSLM 876

  Fly   966 HTEKAKVTKGVGGDSTSSSAKKTRSKTYISRTESHNLSLDKSRSSASNMVDDYE----------- 1019
            ....|.|......|...:||..:.:    .:....||:.....:::||....|:
  Fly   877 AAAAAAVAASRPQDGVDTSAVPSAA----VQAAVVNLAAAMRMNNSSNGATPYQQHHADHTQAHQ 937

  Fly  1020 --IISPATHPPNQISSSPLHIKQEQEQQQRVQLMYDDNLLIDAALLREKTYEKFNPSI------- 1075
              |:..| ||.:       |.:|:..|.|:.||   .:||:........:..:.:|:|
  Fly   938 THILQHA-HPHH-------HQQQQAPQHQQQQL---SHLLVHTHPSNSNSRSQSSPNINVPSLQN 991

  Fly  1076 --------VNDLEEILRSPL----------------KHERNSRLRFTSESSTTPQYL-------- 1108
                    :|....::|..|                :|::.........:|..||:.
  Fly   992 ESTAASIAMNMNVHMMRGSLDPDPSLGGMHGIEVLHQHQQQHHHHHHHHTSNYPQHAVTPTNQHT 1056

  Fly  1109 ------------HEEEQNLIKIEPTSPDLREMLEGQQRVIAHSGSTPSSSSSARTSRHLRQITAN 1161
                        |...:..:::......||...|...|:.  :||.|.:.......::  |:.:|
  Fly  1057 HPHPQTHQTAHHHTSPETALRMHQAEAILRSHTEAAFRLA--TGSGPDTGVKCEADQN--QLNSN 1117

  Fly  1162 GA-RAGSKRTTGG 1173
            .| .||.  .:||
  Fly  1118 NAGNAGG--NSGG 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368
		C2H2 Zn finger	170..186	CDD:275368
		COG5048	326..734	CDD:227381	80/318 (25%)
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	424..444	CDD:275368	2/6 (33%)
		C2H2 Zn finger	476..496	CDD:275368	2/19 (11%)
		C2H2 Zn finger	504..523	CDD:275368	3/18 (17%)
		C2H2 Zn finger	534..554	CDD:275370	2/19 (11%)
		C2H2 Zn finger	562..582	CDD:275370	3/19 (16%)
		C2H2 Zn finger	589..609	CDD:275368	5/20 (25%)
		C2H2 Zn finger	620..640	CDD:275368	7/19 (37%)
		C2H2 Zn finger	648..668	CDD:275368	6/19 (32%)
		zf-H2C2_2	661..685	CDD:290200	13/25 (52%)
		C2H2 Zn finger	676..696	CDD:275368	9/21 (43%)
		C2H2 Zn finger	709..726	CDD:275371	4/16 (25%)
		Hph	921..>1017	CDD:290417	22/124 (18%)
dati	NP_001245421.1	COG5048	<429..>511	CDD:227381	32/81 (40%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	12/23 (52%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		zf-H2C2_2	481..508	CDD:290200	13/26 (50%)
		C2H2 Zn finger	497..519	CDD:275368	9/21 (43%)
		C2H2 Zn finger	533..557	CDD:275368	8/31 (26%)
		C2H2 Zn finger	576..594	CDD:275368	0/17 (0%)
		C2H2 Zn finger	667..687	CDD:275370	3/19 (16%)
		C2H2 Zn finger	702..719	CDD:275370	0/16 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100