DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7987 and CG3281

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	630	Identity:	128/630 - (20%)
Similarity:	207/630 - (32%)	Gaps:	213/630 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 HLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAADSSSAIKFEHQTQRQLDDHYYEQEWP 232
            |||:.|..|      ||..::...|.::|                   |:|.:.|.:
  Fly    63 HLCQNCARR------LIGAYEFIVEVENA-------------------HETLQNLFE-------- 94

  Fly   233 LFQHQQEQENAQQNVH-QQHQIVEEGGIQLVASYPDTVAQPAAPSRGRISRLKPKEESSQFIVIS 296
                |||.......|| ...:::::..:..:|.|..|                  ..:.|.:.:.
  Fly    95 ----QQEVAAKPDEVHVDVVELIDQDDVVSMAQYLST------------------SFAEQHVEME 137

  Fly   297 DK-SVEDSRPYMEPEPAQPVVTTSEFIAVEPPPQPNFPVLDHSKPFVCQQCGLAFAREKALVSHT 360
            :| ..:|...:......:|:..:.:   .:..|:.:|.:    ||...:......:|...|.|..
  Fly   138 EKYGDQDCSAFTSDVGEEPLYASED---RDDEPEDSFQL----KPRPDEIENRELSRPSQLGSRL 195

  Fly   361 KNHRVDSPFECNQCQEMFWDNSSLQEHQKTHQFEESNSEYDPASAEESGSESEADEQLYGEFYCN 425
             ||..:..::|..|..:|..:.||..|     |.:::......:|.:..:||...    |...|.
  Fly   196 -NHSANFIYKCAVCPRVFAKSESLTRH-----FSQAHKLTADVAAMKLANESCGT----GLLTCE 250

  Fly   426 ECGISFHRQDLLRRHAK-MHCKPSDQAAVGSNSDVTAGGDVELAKDSSGHCCNTCGKSFPSALEM 489
            .|..:|.|||.||||.: .|                                       |.|:.:
  Fly   251 HCPRTFKRQDTLRRHMQAFH---------------------------------------PDAIAL 276

  Fly   490 LAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPSELNANSCVLCGKECRDRKALIKHAWDH 554
                                               .|.|...||.         ||.:.|.
  Fly   277 -----------------------------------EPEETTDNSA---------RKRIAKR---- 293

  Fly   555 SREKCHSCSKCGKNFHNKA---RLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTTPGK 616
                 ..|..||.:|...:   .::||..   |....|:.|::.||..:.||.|...|:...|.:
  Fly   294 -----RDCPHCGLSFPVSSLTIHIRRHTG---DNPYKCDQCEKAFPRSQDLSLHMRQHTGERPSE 350

  Fly   617 LFPCLECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPR 681
               |..|.|.|.|::....|:|:|||:|||.|:.|.|:|.....|:.|.|.||||:||.|.||..
  Fly   351 ---CKICSKKFISQNKLARHMRLHTGQRPYSCKMCSKSFVQSNDLKIHMRRHTGERPYQCGVCGE 412

  Fly   682 AFNQRVVLREHIRSH-----HSGLDVARNTYHCTVCSEDLAS-------SNDLIQHLIQHSDSNT 734
            :|    |...|:..|     |....:..|.......::...:       |.|:.:..:|....|.
  Fly   413 SF----VCGSHLNIHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQRIPENQ 473

  Fly   735 AKQR-----QPVTGPRKYK----------------RRRKLQPHEI 758
            .:||     :|......||                .|.|:..:||
  Fly   474 LQQRLENLPKPDVPAMCYKCGVCEQKFKSGALLTVHRNKMSHYEI 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368
		C2H2 Zn finger	170..186	CDD:275368	5/15 (33%)
		COG5048	326..734	CDD:227381	94/423 (22%)
		C2H2 Zn finger	343..363	CDD:275368	3/19 (16%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	10/20 (50%)
		C2H2 Zn finger	476..496	CDD:275368	2/19 (11%)
		C2H2 Zn finger	504..523	CDD:275368	0/18 (0%)
		C2H2 Zn finger	534..554	CDD:275370	3/19 (16%)
		C2H2 Zn finger	562..582	CDD:275370	6/22 (27%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		C2H2 Zn finger	620..640	CDD:275368	7/19 (37%)
		C2H2 Zn finger	648..668	CDD:275368	7/19 (37%)
		zf-H2C2_2	661..685	CDD:290200	13/23 (57%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	709..726	CDD:275371	2/23 (9%)
		Hph	921..>1017	CDD:290417
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071	11/53 (21%)
		C2H2 Zn finger	205..226	CDD:275368	7/25 (28%)
		C2H2 Zn finger	249..266	CDD:275368	9/16 (56%)
		COG5048	<294..>391	CDD:227381	33/102 (32%)
		C2H2 Zn finger	296..315	CDD:275368	4/18 (22%)
		zf-H2C2_2	307..330	CDD:290200	5/25 (20%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..358	CDD:290200	8/25 (32%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-H2C2_2	364..388	CDD:290200	12/23 (52%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	13/28 (46%)
		C2H2 Zn finger	407..424	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100