DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7987 and CG43347

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	NP_001138185.2	Gene:	CG43347 / 31991	FlyBaseID:	FBgn0263072	Length:	2684	Species:	Drosophila melanogaster

Alignment Length:	1480	Identity:	254/1480 - (17%)
Similarity:	461/1480 - (31%)	Gaps:	423/1480 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GAGASGEDLDHVAAENLIFMARDGQLSEIMAANEAGRTVLVTADGTTVAYAESFDDDAQVVTEEV 96
            |:|.:|....:..::.....|....|....||..|........:......||....:.:..::|.
  Fly   718 GSGGAGAGFSYAKSKKQEAKAATAALKASAAAAAAAAASSALPEVLDCRIAEKIKSELEANSKES 782

  Fly    97 ITDDWVQHQGAERVEIAAEQIAGIS-----SSQELLDMEQDEYTALRPY--PCDFCSRRFRKKAT 154
            :.:.....:.|.....||...|.::     |.:|..|.:|..:..|.|.  |.|...     ..|
  Fly   783 LPNALCLKKAAAAAAAAAAAAAAVAAAANGSEEEDEDEDQPPHPHLLPVLPPADAVD-----GIT 842

  Fly   155 LNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAADSSSAIKFEHQTQ 219
            .:|....:.:.|   .|..|::.|:.|:..:.......:.|..|.|..|....:..    :....
  Fly   843 ASNGQAGNFHVR---SKSQGSKKSQAAKAAAAAMMPPNSYDEHDDEPGAGLGGNDE----DDDDD 900

  Fly   220 RQLDDHYYEQEWPLFQHQQEQENAQQNVHQQHQI------------------------------- 253
            .:||:....:|..:.|:..|:|:......:.||.
  Fly   901 EELDEEALAREMKMEQNFVEEEDEHDIAFRSHQSCRECSIAHDHKLCPLRNACGNVTDAVDLGEW 965

  Fly   254 VEEGGIQLVASYPDTVAQPAAPSRGRISRLKPKEESSQFIVISDKSVEDSRPYMEPEPAQPVVTT 318
            :|...::.:|.......:.|..:.|   |.:.:::..:.:...|..:::|....|.| .:|::|.
  Fly   966 IERRNLEALAKLKADAQRQAKRASG---RQRHEDDDMEDMEDMDMDMDESSQLSELE-TKPLITF 1026

  Fly   319 SEFIAVEPPPQPNFPV---LDHSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECNQCQE---M 377
            :|         .:.|.   |.:.:|.|..    .|||.:..........:..|.:..:.:|   |
  Fly  1027 AE---------ASVPAEFELHNVEPNVTG----VFARTEVRAFTKLGPLIGQPVQTGEVREGSDM 1078

  Fly   378 FW-----------------DNSS----LQEHQKTHQFEESNSEYDPASAEESGSESEADEQLYGE 421
            .|                 ||.:    |:..:....:||.|...
  Fly  1079 KWIFEMCEAGADKSYLLCCDNPNASNWLRFVRPAPSYEERNVNL--------------------- 1122

  Fly   422 FYCNECGISFHRQDLLRRHAKMHCKPSDQAAVGSNSDVTAGGDVELAKDSSGHCCNTCGKSFPSA 486
                   :|..||...     :.|:           |:..|.::....|.    |||..:.
  Fly  1123 -------VSIDRQAYF-----VSCR-----------DLRNGMELLYWSDD----CNTMWRK---- 1156

  Fly   487 LEMLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPSELNAN----SCVLCGKECRDRKAL 547
                .|.|      ...|..|.:.|......:.|....|...::..    .|.:||:....:..:
  Fly  1157 ----KHTE------KTNCGGCNLKFEHPLYYRTHCSVFHDPSMSLTIRKYHCKVCGEPVLGKDNI 1211

  Fly   548 IKHAWD-HSREKCHSCSKCGKNFHNKARLKRH----MASHRDKS-VVCEVCQEEFPDGRTLSNH- 605
            :|||.: |..:..:.|..|.|.|.....|:.|    .||:.::| .||:.|..:|...:.|..|
  Fly  1212 MKHAAEKHDGKGAYQCQFCSKFFLRLNYLEMHRTYGCASNPNRSRPVCDFCGRKFCQPQKLKAHI 1276

  Fly   606 RHSHSTTTPG-KLFPCLECGKTFGSRSSQQIHVR-IHT-GERPYGCRYCWKAFADGGTLRKHERI 667
            :..||..... :.|.|..|.|..|||::.|.|.: :|: ......|..|.|.|.:...|:.|...
  Fly  1277 KRMHSDMAEVLRDFQCKLCSKLLGSRAALQRHSKEVHSRNSTVVSCPRCQKLFQNRSNLKIHMLT 1341

  Fly   668 HTGEKPYACS--VCPRAFNQRVVLREHIRSHHSGLD-----VARNTYHCTVCSEDLASSNDLIQH 725
            |:|.:|:.|:  .|..||..:..|:.|.:..|:...     :.|:..:    :.|..|....:..
  Fly  1342 HSGVRPFKCAEPECNAAFTTKQCLQFHYKKVHNYTQEQMPKIERSVAY----TFDAYSGGMKVDF 1402

  Fly   726 LIQHSDSNT-----AKQRQP-----VTGPRKY-----KRRRKLQPHEIAHMRAANKHVNGDEEEA 775
            |.:.:.:.|     :.|.||     |..|..:     :||||                :.:::.:
  Fly  1403 LGKQTATATPASAASAQAQPRPNAAVVSPSSFTEQAPRRRRK----------------SLEDQSS 1451

  Fly   776 IGEGDAEECASDIDFCDFDVENVDDIFDMAESPKK------------------------EKRKRG 816
            :..|..:   ||.:|.|      |::|:..:...|                        :|....
  Fly  1452 MLSGSLQ---SDAEFSD------DNLFEAIKKSGKSIKDLCRNEPNLSLLSSKISSIFGDKVPSA 1507

  Fly   817 SAATKADAKPVTNGKAAKPAQDKGKAKP-----------RYDSTSSQQSDRLWEEKFLHDSQVAL 870
            :|:..|....|.:..|.|..:.|....|           :......|||....:.:..|..|:..
  Fly  1508 TASLSASVSAVASSGARKRKRKKEPVVPAQQQLHLHQQQQQQQQQQQQSQHQQQHQQQHAQQLQH 1572

  Fly   871 FQIDSLVV---------VNDTHLQ-------------PASSAVSANIPNTRGGSKQQGKVQAKSV 913
            .|:.....         ::..|.|             |......| :|:.:...:||.:.|.:.:
  Fly  1573 QQLQQQHAQQHQQQQHHLHQQHQQLHHDPQQQHPQYHPHQLHAHA-LPHQQQQQQQQQQQQQQQL 1636

  Fly   914 EG-----------------AENLNSSATTSDTTFSASTSTASTRSRKRAATTKTASKAPPASNSR 961
            .|                 .:|...|...|..|.:|...:|..:.::..|.....|....|....
  Fly  1637 HGDPDDEEVENARLEQVRRKQNAQLSLVESFLTTTAQRLSAQQQVQQVVAAAAAVSAMAGAGEDP 1701

  Fly   962 PRMIH-TEKAKVTKGV---------------GGDSTSSSAKKTRSKTYISRTESHNLSLDKSRSS 1010
            .::.| .....|..||               ||..........:...::...::|
  Fly  1702 AKLGHMMGHMGVGVGVGMDEEEDDDEDDDDGGGGGGGGGGSAVQHHPHVHAHQAH---------- 1756

  Fly  1011 ASNMVDDYEIISPATHPPNQISSSPLHIKQEQEQQQRVQLMYDDNLLIDAALLREKTYEKFNPSI 1075
                   :..:....||.:  :.|..|..|....|...|..|.....::|||.:.....|.:...
  Fly  1757 -------HSHVHAHAHPHH--AHSHAHPHQHPASQGAGQQDYRHAAAMNAALGQNLVVSKGSKKW 1812

  Fly  1076 VNDLEE------------------------------------------ILRSPLKHERNSRL--- 1095
            :.::::                                          ....|...:.:|:|
  Fly  1813 IQEVQDSSDVGGEGAGGGGGGPGDSGGPGGGGACGQLAGGSGPGPDLGFAVPPTAVDEHSKLLGQ 1877

  Fly  1096 ------RFTSESSTT--------------PQYLHEEEQNLIKIEPTSPDLREMLEGQQ--RVIAH 1138
                  |..|.:|.:              |...|::.|:       |...||..|...  .|:..
  Fly  1878 NRDFLARLMSSASASHAHAHAHAHAHAHQPHQTHQQHQH-------SAHSREEDENSSFLDVVES 1935

  Fly  1139 SGSTPSSSSSARTSRHLRQITANGARAGSKRTTGGVASKTSASP----GVVAKKSNTATKVSS-S 1198
            :.:..:::::|....|.      |..|||....||...:|...|    |.||.......:::| :
  Fly  1936 NNNAAAAAAAAAALSHY------GGGAGSGSAGGGSGGQTPTGPATGGGSVAGGDEPQMQMNSLA 1994

  Fly  1199 SSSSYLSYGVDSYNVNVPASANNGDVGSGFFSISEVVSAADAADAAAKAA 1248
            .|.|::|   ..||   .|:|..|.||.|...:. |...:.:|....:||
  Fly  1995 HSQSFMS---SFYN---NANARVGGVGGGVVGVG-VGGGSSSASMLVEAA 2037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368	3/19 (16%)
		C2H2 Zn finger	170..186	CDD:275368	4/15 (27%)
		COG5048	326..734	CDD:227381	88/455 (19%)
		C2H2 Zn finger	343..363	CDD:275368	3/19 (16%)
		C2H2 Zn finger	371..391	CDD:275368	6/43 (14%)
		C2H2 Zn finger	424..444	CDD:275368	3/19 (16%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		C2H2 Zn finger	504..523	CDD:275368	4/18 (22%)
		C2H2 Zn finger	534..554	CDD:275370	6/20 (30%)
		C2H2 Zn finger	562..582	CDD:275370	7/23 (30%)
		C2H2 Zn finger	589..609	CDD:275368	5/20 (25%)
		C2H2 Zn finger	620..640	CDD:275368	8/20 (40%)
		C2H2 Zn finger	648..668	CDD:275368	6/19 (32%)
		zf-H2C2_2	661..685	CDD:290200	9/25 (36%)
		C2H2 Zn finger	676..696	CDD:275368	6/21 (29%)
		C2H2 Zn finger	709..726	CDD:275371	2/16 (13%)
		Hph	921..>1017	CDD:290417	15/111 (14%)
CG43347	NP_001138185.2	NR_DBD_like	1198..>1268	CDD:295381	20/69 (29%)
		C2H2 Zn finger	1198..1219	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1227..1255	CDD:275368	8/27 (30%)
		C2H2 Zn finger	1259..1280	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1292..1313	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1322..1342	CDD:275368	6/19 (32%)
		zf-H2C2_2	1334..1361	CDD:290200	9/26 (35%)
		C2H2 Zn finger	1350..1373	CDD:275368	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100