DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7987 and Zfp219

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	NP_001007682.1	Gene:	Zfp219 / 305848	RGDID:	1359259	Length:	726	Species:	Rattus norvegicus

Alignment Length:	804	Identity:	169/804 - (21%)
Similarity:	255/804 - (31%)	Gaps:	254/804 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 RPYPCDFCSRRFRKKATLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAH------------ 190
            |.:||..|.:|||..:.|..|:.||...:...|..||.|.::||.|.||.:.|
  Rat    59 RRFPCPVCGKRFRFNSILALHLRAHPGAQAFQCPHCGHRAAQRALLRSHLRTHQPERPRSPAARL 123

  Fly   191 ---------------AEAQDAADAEAAAAA-------ADSSSAI-------KFEHQTQRQLDDHY 226
                           ..|:.:...:::.||       ..||||.       ||....:|:...|.
  Rat   124 LLELEERALLREARLGRARSSGGMQSSPAAEGLARPQVPSSSAFRCPFCKGKFRTSAERERHLHI 188

  Fly   227 YEQEWPL----FQHQQEQENAQQNVHQQHQIVEEGGIQLVASYPDTVAQPAAPSRGRISRLKPKE 287
            ..:.|..    |...||:|    .:|  |.:...|..:...:...|......|.:...|.|:|:.
  Rat   189 LHRPWKCSLCSFGSSQEEE----LLH--HSLTAHGASERPLAATATPEPQPPPQQEPRSALEPEP 247

  Fly   288 ESSQFIVISDKSVEDSRPYMEPEP---AQPVVTTSEFIAVEPPPQPNFPVLDHSKPFVCQQCGLA 349
            |                |...|||   |.|..|.:      ||.:|..|     ..|.||.||.:
  Rat   248 E----------------PEPRPEPEREANPAPTPA------PPEEPPAP-----PEFRCQVCGQS 285

  Fly   350 FAREKALVSHTKNHRVDSPFECNQCQEMFWDNSSLQEHQKTHQFEESNSEYDPASAEESGSESEA 414
            |.:...|..|.:.|:......|..|...|.:...|:.|.|.|     .|:..|..|...||....
  Rat   286 FTQSWFLKGHMRKHKASFDHACPVCGRCFKEPWFLKNHMKVH-----TSKLGPLRAPGPGSAPAR 345

  Fly   415 DEQLYGEFYCNECGISFHRQDLLRRHAKMHCKPSDQAAVGSNSDVTAGGDVELAKDSSGHCCNTC 479
            ..|                             |.|.:.              ||.:..|
  Rat   346 APQ-----------------------------PPDLSL--------------LAYEPLG------ 361

  Fly   480 GKSFPSALEMLAHAEIHARFPPFKCVLCGISFYEEQAIKRHLHTRHPSELNANSCVLCGKECRDR 544
                |:.|...|......|.||              ::..:|..| ..|:..|.      |..|.
  Rat   362 ----PALLLAPAPTPAERREPP--------------SLLGYLSVR-AGEVRPNG------EGADP 401

  Fly   545 KALIKHAWDHSREKCHSCSKCGKNF----------HNKARLKRHMASHRDKSVVCEVCQEEFPDG 599
            ..                   |:::          .|:||..|......::.|| |..:|.:..|
  Rat   402 GG-------------------GRSYGGFRPLPSALPNRARRHRTEEPEEEEEVV-EAEEESWARG 446

  Fly   600 RTLSNHRHSHSTTTPGKLFPCLECGKTFGSRSSQQIH------VRIHTGERPYG--CRYCWKAFA 656
            |:|.:....|.....|........|....|.::|:.:      .|...|....|  |.:|.|:|.
  Rat   447 RSLGSLTSLHPNPGEGSGQSAPAVGAQARSTATQEENGLLVGGTRSEAGRGATGKDCPFCGKSFR 511

  Fly   657 DGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHH------------------------ 697
            ....|:.|.|:||||:||.|..|..|..|...|:.|::.||
  Rat   512 SAHHLKVHLRVHTGERPYKCPHCDYAGTQSGSLKYHLQRHHREQRSSAGPGPPPEPPPPSQRGSL 576

  Fly   698 ---SGLDVARNTYHCTVCSEDLASSNDLIQHLIQHSDSNTAKQRQPVTGPRKYKRRR--KLQPHE 757
               ||   |:.|.......|..||:..      ..|.:....:|:|.:..|..:..|  :.:|.:
  Rat   577 QPQSG---AKPTQASATWVEGTASTRP------TSSSTGPGSRRKPASPGRTLRNGRGGEAEPLD 632

  Fly   758 IAHMRAANKHVNGDEEEAIGEGDAEECASDIDFCDFDVENVDDIFDMAESPKKEKRKRGSAATKA 822
            :: :||      |...||...|....|.    ||.| .....::..:.......:|.||....:|
  Rat   633 LS-LRA------GPGGEAGSGGALHRCL----FCPF-ATGAPELMALHLQVHHSRRARGRRQPRA 685

  Fly   823 DAKP----VTNGKA--AKPAQDKG 840
            |..|    ..:|:.  :.|.:::|
  Rat   686 DTSPPYVRAPSGETPPSPPLEEEG 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368	7/19 (37%)
		C2H2 Zn finger	170..186	CDD:275368	7/15 (47%)
		COG5048	326..734	CDD:227381	92/452 (20%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	0/19 (0%)
		C2H2 Zn finger	476..496	CDD:275368	3/19 (16%)
		C2H2 Zn finger	504..523	CDD:275368	1/18 (6%)
		C2H2 Zn finger	534..554	CDD:275370	2/19 (11%)
		C2H2 Zn finger	562..582	CDD:275370	5/29 (17%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		C2H2 Zn finger	620..640	CDD:275368	4/25 (16%)
		C2H2 Zn finger	648..668	CDD:275368	7/19 (37%)
		zf-H2C2_2	661..685	CDD:290200	12/23 (52%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	709..726	CDD:275371	3/16 (19%)
		Hph	921..>1017	CDD:290417
Zfp219	NP_001007682.1	C2H2 Zn finger	63..83	CDD:275368	7/19 (37%)
		zf-C2H2	89..111	CDD:395048	9/21 (43%)
		C2H2 Zn finger	91..111	CDD:275368	9/19 (47%)
		C2H2 Zn finger	169..187	CDD:275368	3/17 (18%)
		C2H2 Zn finger	195..211	CDD:275368	5/21 (24%)
		zf-C2H2	277..299	CDD:395048	8/21 (38%)
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		zf-C2H2	305..327	CDD:395048	6/21 (29%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
		zf-C2H2	503..523	CDD:395048	7/19 (37%)
		zf-H2C2_2	515..537	CDD:404364	11/21 (52%)
		zf-H2C2_5	529..552	CDD:404746	7/22 (32%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000