DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7987 and Zfp536

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	XP_011248882.1	Gene:	Zfp536 / 243937	MGIID:	1926102	Length:	1380	Species:	Mus musculus

Alignment Length:	1497	Identity:	302/1497 - (20%)
Similarity:	473/1497 - (31%)	Gaps:	453/1497 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 EDLDHVAAENLIFMARDGQ-LSEIMA--ANEAGRTVLVTADGTTVAYAESFDDDAQVVTEEVITD 99
            |:....|.|....:...|| :...||  ||:.||.|..:.:|..         |.|
Mouse    57 EEKTPAALEEKAHVPMSGQSMGSQMALLANQLGRDVDNSLNGRV---------DLQ--------- 103

  Fly   100 DWVQHQGAERVEIAAEQIAGISSSQELLDMEQDEYTALRPYPCDFCSRRFRKKATLNNHMLAHQN 164
                       :....|..||.|  ::.|:| |:....|.|||..|.:|||..:.|:.||..|..
Mouse   104 -----------QFLNGQNLGIMS--QMSDIE-DDARKNRKYPCPLCGKRFRFNSILSLHMRTHTG 154

  Fly   165 DRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAAADSSSAIKFEHQTQRQLDDHYY-- 227
            ::|..|..|..|.:::..|..|.:.|          ...........::.|::...:|::...
Mouse   155 EKPFKCPYCDHRAAQKGNLKIHLRTH----------KLGNLGKGRGRVREENRLLHELEERAILR 209

  Fly   228 --EQEWPLFQ---------HQQEQENAQQNV-----HQQHQIVEEGGIQLVASYPDTVAQPAAPS 276
              :.:..|.|         |.|:...|..|:     |....:.........|:..:....|||..
Mouse   210 DKQMKGSLLQPRSDLKPLAHAQQAPLATCNLALPPNHSVPDVAHPAPSPKPANLQEDSVTPAAGF 274

  Fly   277 RGRI--SRLKPKEESSQFIVISDKSVEDSRPY---------MEPEPAQPVVTTSEFIAVEPPPQ- 329
            |...  .:.|.:||..:.|.|..|      ||         .:.|.....|..:...|.....|
Mouse   275 RCTFCKGKFKKREELDRHIRILHK------PYKCTLCDFAASQEEELISHVEKAHITAESAQGQG 333

  Fly   330 PNFPVLDHSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFE--CNQCQEMFWDNSSLQEHQKTHQ 392
            ||......:..|.|:.||..|::...|..|.:.|: || ||  |..|...|.:...|:.|.|.|.
Mouse   334 PNGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHK-DS-FEHCCQICGRRFKEPWFLKNHMKVHL 396

  Fly   393 FEESNSEYDPASAEES----GSESEADEQLYGEFY-CNECGISFHRQDLLRRHAKMHCK---PSD 449
            .:.|.....|...|.:    |...||...||..:. |.:.|.....:..|...::::.|   |:.
Mouse   397 NKLSVKNKSPTEPEVAVPMGGLSQEAHANLYSRYLSCLQSGFMAPDKASLNEPSQLYGKGELPAK 461

  Fly   450 Q--------AAVGSNSDVTAGGDVELAKDSSGHCCNTCGKSFPSALEMLAHAEIHARFPP----- 501
            :        :.:.|.:.....||    |.|...|.|.......|.:|.|..|...|...|
Mouse   462 EKEVLGKLLSPISSMAHSVPEGD----KHSLLGCLNLVPPLKSSCIERLQAAAKAAEMDPVNSYQ 522

  Fly   502 -FKCVLCGISFYEEQAIKRHLHTRHPSELNANSCVLCGKECRD---------------------- 543
             ::.:..|::.......|.|..:|:..:..||:.||..||.|:
Mouse   523 AWQLMARGMAMEHGFLSKEHQLSRNHEDPLANTGVLFDKEKREYVLVGADGSKQKMPADLVHSTK 587

  Fly   544 ----------------RKALIKHAWDHS-----------REKCHSCSKCGKNFHNKARLKRHMAS 581
                            .:..:.|..:.:           :||...|..||:.|....::..|...
Mouse   588 VGNQRDLPNKLDPLEGSREFLSHGLNQTLDYNLQGPGNMKEKPTECPDCGRVFRTYHQVVVHSRV 652

  Fly   582 H-RDKSVVCEVCQEEFPDGRTLSNHRHSHS---------TTTPGKLFPCLECGKTFG-------- 628
            | ||:    :..::....|..|...|.|.|         :||||......|.|...|
Mouse   653 HKRDR----KSDEDALHVGVGLEERRGSGSDQESQSVSRSTTPGSSNVTEESGAGGGLSQTGSAQ 713

  Fly   629 -------SRSS--------------QQIHVR-IHTGERPYGCRYCWKAFADGGTLRKHERIHTGE 671
                   |.||              ||..:| .:.|.....|.||.|.|.....|:.|.||||||
Mouse   714 EDSPHPSSPSSSDIGEEAGRAGGVQQQALLRDRNLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGE 778

  Fly   672 KPYACSVCPRAFNQRVVLREHIRSHH----------SGL--------------------DVARNT 706
            |||.|..|..|..|...|:.|:..||          ||.                    |:.|..
Mouse   779 KPYKCPHCDYAGTQSASLKYHLERHHRERQNGAGPLSGQPPNQEHKDETSSKAPMFIRPDILRGA 843

  Fly   707 YH------------CTVCSEDLASSNDLIQHLIQHSDSNTAKQRQPVTGPRKYKRRRKLQPHEIA 759
            :.            ....:..:.||.|       ||...|.                  .|.|::
Mouse   844 FKGLPGIDFRGGPASQQWTAGMLSSGD-------HSGQATG------------------MPSELS 883

  Fly   760 H--MRAANKHVNGDEEEAIGEGDAEECASDIDFCDFDVENVDDIFDMAESPKKEKRKRGSAATKA 822
            .  ::.::..........||.......::.::| ...::...|.|.::...||:.:.:    ..:
Mouse   884 SDALKGSDLPSKSSHYSEIGRAYQNIVSNGVNF-QGSLQAFMDSFVLSSLKKKDTKDK----VPS 943

  Fly   823 DAKPVT-------NGKAA-KPAQDKGKAKPRYD---------------STSSQQSDRLWEEKFLH 864
            ||.|:.       ..||: ||:|.|.: |.:|:               |:.:.|....|     |
Mouse   944 DAHPMKAHTAEGGEEKASMKPSQRKSE-KSQYEPLDLSVRPDAPTLPGSSVTVQDSIAW-----H 1002

  Fly   865 DSQVALFQIDSLVV----VNDTHLQPAS-----SAVSANIPNTRGGSKQQGKVQAKSVEGAENLN 920
            ......|...|:.:    :...||..|.     :.|:.|       .|:||: :|..|....:|.
Mouse  1003 GCLFCAFTTSSMELMALHLQANHLGRAKRKDHPTGVTVN-------CKEQGR-EASKVSVLPSLQ 1059

  Fly   921 SSATTSDTTFSASTSTASTRSRKRAATTKTASKAPPASNSRPRMIHTEKAKVT------KGVG-- 977
            |:   .:....::.....:...|.|......:...|.|...|.  |.:.|..|      |..|
Mouse  1060 SN---KEMALPSAVGVLDSAPEKLAQGPAKETLGDPKSGQWPN--HMDPAFCTFPSDFYKQFGVY 1119

  Fly   978 ------GDSTSSSAKKTRSKTY--------ISRTESHNLSLDKSRSSASNMVD--------DYEI 1020
                  |...|...|.|..||:        |..|.:.|.:.|.|..::|..:|        |.|:
Mouse  1120 PAMVGSGAPGSCLNKNTEGKTHPDDDAPILIPETTNKNTTDDLSDIASSEDMDSSKGENNEDEEL 1184

  Fly  1021 ISPATHPPNQISSSPLHIKQEQEQQQRVQLMYDDNLLIDAALLREKTYEKFNPSIVNDLEEILRS 1085
               .|.|  :::|.||....:....:.     .|:||              :|.....::.:: |
Mouse  1185 ---DTEP--EMTSKPLSALSKDGSSEG-----GDSLL--------------SPGAPQPIQGLV-S 1224

  Fly  1086 PLKHERNSRLRFTSESSTTPQYLHEEEQN--LIKIEPTSPDLREMLEGQQRVIAHSGSTPSSSSS 1148
            ||       .:...|...:|..|..::.:  |.|.|...|.|.:               |.|..|
Mouse  1225 PL-------AQAAEEQWHSPGLLPAQDPSAGLPKPERGPPGLEK---------------PMSMLS 1267

  Fly  1149 ARTSRHLRQITANGARAGSKRTTGGVASKTSAS-------------------PGVVAKKSNTATK 1194
            .     ||..:|:|..|     ..|:||.|:.|                   |...::|.|..|.
Mouse  1268 V-----LRAYSADGLAA-----FNGLASSTANSGCIKRPDLCGHRPFQCHYCPYSASQKGNLKTH 1322

  Fly  1195 V-----SSSSSSSYLSYGVDSYNVNVPASANNGDVGSGFFSISEVVSAADAADAAAKAAAAGKSE 1254
            |     ....:|.|.........|:..||.|           .|..:|..|...|......||.:
Mouse  1323 VLCVHRMPFDNSQYPDRRFKRSRVDAEASGN-----------LEEAAAVKAGSFAELTDERGKGQ 1376

  Fly  1255 RK 1256
            .:
Mouse  1377 EE 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368	8/19 (42%)
		C2H2 Zn finger	170..186	CDD:275368	4/15 (27%)
		COG5048	326..734	CDD:227381	122/563 (22%)
		C2H2 Zn finger	343..363	CDD:275368	6/19 (32%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	3/19 (16%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		C2H2 Zn finger	504..523	CDD:275368	3/18 (17%)
		C2H2 Zn finger	534..554	CDD:275370	6/57 (11%)
		C2H2 Zn finger	562..582	CDD:275370	5/19 (26%)
		C2H2 Zn finger	589..609	CDD:275368	3/19 (16%)
		C2H2 Zn finger	620..640	CDD:275368	9/49 (18%)
		C2H2 Zn finger	648..668	CDD:275368	8/19 (42%)
		zf-H2C2_2	661..685	CDD:290200	14/23 (61%)
		C2H2 Zn finger	676..696	CDD:275368	6/19 (32%)
		C2H2 Zn finger	709..726	CDD:275371	3/16 (19%)
		Hph	921..>1017	CDD:290417	24/125 (19%)
Zfp536	XP_011248882.1	COG5048	103..>180	CDD:227381	26/99 (26%)
		C2H2 Zn finger	132..152	CDD:275368	8/19 (42%)
		zf-H2C2_2	145..169	CDD:404364	8/23 (35%)
		C2H2 Zn finger	160..180	CDD:275368	5/19 (26%)
		C2H2 Zn finger	276..297	CDD:275368	5/20 (25%)
		C2H2 Zn finger	302..323	CDD:275368	2/20 (10%)
		zf-C2H2	345..367	CDD:395048	7/21 (33%)
		C2H2 Zn finger	347..367	CDD:275368	6/19 (32%)
		zf-C2H2	373..395	CDD:395048	6/21 (29%)
		C2H2 Zn finger	375..395	CDD:275368	6/19 (32%)
		zf-C2H2_assoc	657..739	CDD:406903	15/85 (18%)
		C2H2 Zn finger	755..775	CDD:275368	8/19 (42%)
		zf-C2H2	755..775	CDD:395048	8/19 (42%)
		zf-H2C2_2	767..789	CDD:404364	13/21 (62%)
		zf-H2C2_5	781..804	CDD:404746	7/22 (32%)
		C2H2 Zn finger	783..803	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000