DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7987 and Zfp217

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	NP_001028471.1	Gene:	Zfp217 / 228913	MGIID:	2685408	Length:	1041	Species:	Mus musculus

Alignment Length:	1179	Identity:	221/1179 - (18%)
Similarity:	330/1179 - (27%)	Gaps:	460/1179 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 LISHFKAHAEAQDAADAEAAA-----AAADSSSAIKFEHQTQRQLDDHYYEQEWPLFQHQQEQEN 242
            |.|...:..|..||...:...     ||.:.|.|:...|.   .||..:..|.:      .:.|:
Mouse    16 LSSSLGSQMEVDDAVPIKGPVAVPFRAAQEKSMAVAEGHM---PLDCMFCSQVF------SQAED 71

  Fly   243 AQQNVHQQHQIVEEGGIQLVASYPDTVAQPAAPSRGRISRLKPKEESSQFIVISDKSVEDSRPYM 307
            ..|:|..||:              .|:.:||      :.|::     ::::...||::|.:.|.:
Mouse    72 LSQHVLLQHR--------------PTLCEPA------VLRVE-----AEYLSPLDKALEPTEPAL 111

  Fly   308 EPEPAQPVVTTSEFIAVEPPPQPNFPVLDHSKPFVCQQCGLAFAREKALVSHTKNHRVDSPFECN 372
            |.....|                        :...|..||..|.....:.||.|.|:....:.|:
Mouse   112 EKSGEDP------------------------EELSCDVCGQTFPVAFDVESHMKKHKDSFTYGCS 152

  Fly   373 QCQEMFWDNSSLQEHQKTHQFEESNSEYDPASAEESGSES----------EADEQLYGEF-YCNE 426
            .|...|.:...|:.|.:||     |.:....|..:.|.||          .|...:...: .|..
Mouse   153 MCGRRFKEPWFLKNHMRTH-----NGKSGTRSKLQQGMESPVTINEVVQPHAPGSISTPYKICMV 212

  Fly   427 CGISFHRQDLLRRHAKMHCKPSDQAAVGSNSDV--------------------------TAG--- 462
            ||..|..:..|..|:|:|.|.:    |.|.|:|                          |||
Mouse   213 CGFLFPNKQSLIEHSKVHAKET----VPSASNVAPDDHREEPTSPREELLQFLNLRPRSTAGSTV 273

  Fly   463 -----------------------GDVELAKD---SSGHCCNTCGKSFPSALEMLAH------AEI 495
                                   |.|.:|::   .||...:|......|..|.|..      ||.
Mouse   274 KPMTCIPQLDPFTTYQAWQLATKGKVAVAQEEVKESGQEGSTDNDDSCSEKEELGEIWVGGKAEG 338

  Fly   496 HARFPPFKCVLCGISFYEEQAIKRHLHTRHPSELNANSCVLCGKECRDRKALIKHAWDHSREKCH 560
            ..:....|....|:|..:|:       .||     |||.|..|..  |.|.      ..|:||..
Mouse   339 SGKSKTSKSSCPGLSQDKEK-------PRH-----ANSEVPSGDS--DPKL------SSSKEKPT 383

  Fly   561 SCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTTPGKLFPCLECGK 625
            .||:|.|.|....:|..|...||.......:......|.|.........|||.........|.|.
Mouse   384 HCSECSKAFRTYHQLVLHSRVHRKDRRTDALSPTMAVDARQPGTCSPDLSTTLEDSGAGDREGGS 448

  Fly   626 TFGSRSSQQIHVRIHTGERPYG-----------CRYCWKAFADGGTLRKHERIHTGEKPYACSVC 679
            ..||...  :...:|..:...|           |.||.|.|.....|..|.|.|||||||.|..|
Mouse   449 EDGSEDG--LPDGLHLDKNDDGGKAKPLPSSRECSYCGKFFRSNYYLNIHLRTHTGEKPYKCEFC 511

  Fly   680 PRAFNQRVVLREHIRSHHSGLDVARNTYHCTVCSEDLASSNDLIQHLIQHSDSNTAKQRQPVTGP 744
            ..|..|:..||.|:..||                                      |.:|||
Mouse   512 EYAAAQKTSLRYHLERHH--------------------------------------KDKQPV--- 535

  Fly   745 RKYKRRRKLQPHEIAHMRAANKHVNGDEEEAIGEGDAEECASDIDFCDFDVENVDDIFDMAESPK 809
                                                                      |.|...|
Mouse   536 ----------------------------------------------------------DAAAESK 542

  Fly   810 KEKRKRGSAATKADAKPVTNGKAAKPAQDKGKAKPRYDSTSSQQSDRLWEEKFLHDSQVALFQID 874
            .|                  |::.:|
Mouse   543 SE------------------GRSQEP--------------------------------------- 550

  Fly   875 SLVVVNDTHLQPASSAVSANIPNTRGGSKQQGKVQAKSVEG---AENLNSSATTSDTTFSASTST 936
                 .|..|..|.||.:.|:.....|        ||.|:|   |:.|....:...:..|.:.|.
Mouse   551 -----QDALLTAADSAQTKNLKRFLDG--------AKDVKGSPPAKQLKEMPSVFQSVLSPAHSN 602

  Fly   937 ASTRSRKRAATTKTASKAPPASNSRPRMIHTEKAKVTKGVGGDSTSSSAKKTRSKTYISRTESHN 1001
            .:....|.||.:...::..||    |..:..::.|    .|....||...:......::|...|.
Mouse   603 DTQDFHKHAADSAEKARKSPA----PTYLDMQRKK----AGEPQASSPVCRLEGVGSLAREAGHR 659

  Fly  1002 LSLDKSRSSASNMVDDYEIISPATHPPN--------QISSSPLHIKQEQEQQQRVQLMYDDNLLI 1058
            ..:|:..        ||.      |.|.        .:|..|||      ....:.|   ...||
Mouse   660 EKMDQDA--------DYR------HKPGADCQDRPLNLSLGPLH------ACPAISL---SKCLI 701

  Fly  1059 DAALLREKTYEKFNPSIV-----------------NDLEEILRS---------------PLK--H 1089
            .:......|::.|.|.::                 ...:.:||:               ||.  |
Mouse   702 PSIACPFCTFKTFYPEVLMMHQRLEHRYNPDPHKNGSSKSVLRNRRTGCPPALLGKDVPPLSGLH 766

  Fly  1090 ERNSRLRFTSESSTTPQYLHEEEQNLIKIEPTSPDLREMLEGQQRVIAHSGSTPSSSSSARTSRH 1154
            :..::..|:..|.:    ||.|:            .|:...|..:....||...|:.:.:....|
Mouse   767 KPKAKTAFSPHSKS----LHSEK------------ARQGASGPSKAPQTSGPDNSTLAPSNLKSH 815

  Fly  1155 LRQITANGARAGSKRTT-----GGVASKTSASPGVVAKKSNTATKVSSSSSSSYLSYGVDSYNVN 1214
            ..|..|.|..|..::.:     |||       |..:.|......|:.|..:|...|
Mouse   816 RSQPNAGGTSATRQQQSELFPKGGV-------PAAMDKVKRPEPKLKSLPASPSQS--------- 864

  Fly  1215 VPASANNGD 1223
             |.|:||.:
Mouse   865 -PLSSNNSN 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368
		C2H2 Zn finger	170..186	CDD:275368	1/2 (50%)
		COG5048	326..734	CDD:227381	108/490 (22%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		C2H2 Zn finger	371..391	CDD:275368	5/19 (26%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	476..496	CDD:275368	6/25 (24%)
		C2H2 Zn finger	504..523	CDD:275368	3/18 (17%)
		C2H2 Zn finger	534..554	CDD:275370	4/19 (21%)
		C2H2 Zn finger	562..582	CDD:275370	7/19 (37%)
		C2H2 Zn finger	589..609	CDD:275368	2/19 (11%)
		C2H2 Zn finger	620..640	CDD:275368	4/19 (21%)
		C2H2 Zn finger	648..668	CDD:275368	8/19 (42%)
		zf-H2C2_2	661..685	CDD:290200	13/23 (57%)
		C2H2 Zn finger	676..696	CDD:275368	7/19 (37%)
		C2H2 Zn finger	709..726	CDD:275371	0/16 (0%)
		Hph	921..>1017	CDD:290417	15/95 (16%)
Zfp217	NP_001028471.1	C2H2 Zn finger	59..80	CDD:275368	4/26 (15%)
		C2H2 Zn finger	123..143	CDD:275368	7/19 (37%)
		C2H2 Zn finger	151..171	CDD:275368	5/19 (26%)
		zf-C2H2	151..171	CDD:395048	5/19 (26%)
		C2H2 Zn finger	210..230	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-C2H2	479..500	CDD:395048	8/20 (40%)
		C2H2 Zn finger	480..500	CDD:275370	8/19 (42%)
		zf-H2C2_2	492..517	CDD:404364	13/24 (54%)
		zf-H2C2_5	506..530	CDD:404746	10/61 (16%)
		C2H2 Zn finger	508..529	CDD:275370	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000