DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7987 and Zbtb17

DIOPT Version :9

Sequence 1:	NP_650375.1	Gene:	CG7987 / 41768	FlyBaseID:	FBgn0038244	Length:	1283	Species:	Drosophila melanogaster
Sequence 2:	NP_001365755.1	Gene:	Zbtb17 / 22642	MGIID:	107410	Length:	819	Species:	Mus musculus

Alignment Length:	911	Identity:	208/911 - (22%)
Similarity:	307/911 - (33%)	Gaps:	272/911 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 CSRRFRKKATLNNHMLAHQNDRPHL--CKLCG----------ARFSRRAELISHFKAHA---EAQ 194
            ||..|:.       :...|.|..||  ....|          |:.|...|.:....|.|   :.|
Mouse    45 CSEYFKM-------LFVDQKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVASFLQMQ 102

  Fly   195 DAAD--------AEAAAAAADSSSAIKFEHQTQRQLDDHYYEQEWPLFQHQQEQENAQQNVHQQH 251
            |...        ||.::...:|:.|...|...:|..|    |:.......:.:|.....:.....
Mouse   103 DIVTACHTLKSLAEPSSTTGESADASAVEGGDKRAKD----EKAAATMLSRLDQARGSSSTGPGR 163

  Fly   252 QIVEEGGIQLVAS-----------------YPDTVAQPA----------APSRGRISRLKPKEES 289
            ::.||.|.|..::                 .|:..::|:          ||.......|||...|
Mouse   164 ELKEERGGQAESASSGPVPAMEESPLASGQSPNPASRPSSGAEQTEKADAPREPPPVELKPDPTS 228

  Fly   290 SQFIVISDKSVEDSRPYMEPEPAQ------------PVVTTSEFIAVE--PPPQPN--------- 331
            |.....::...|.|...||.|||.            |.....|.:.::  .||:.|
Mouse   229 SMAAAEAEALSESSEQEMEVEPASKGEDGQEEEGAGPATVKEEGMHLDNGEPPEENEESAGTDSG 293

  Fly   332 --------------FPVLDHSKPF-----VCQQCGLAFAREKALVSHTKNHRVDSPFECNQCQEM 377
                          :.....||.:     .|:.||..|........|.:.|..:.||.|.:|.:.
Mouse   294 QELGMEGQNLRSGTYGDRTESKAYGSIIHKCEDCGKEFTHTGNFKRHIRIHTGEKPFSCRECSKA 358

  Fly   378 FWDNSSLQEHQKTHQFEESNSEYDPASAEESGSESEADEQLYGEFYCNECGISFHRQDLLRRHAK 442
            |.|.::.:.|:|||      |...|                ||   |.|||.|:....||..|.|
Mouse   359 FSDPAACKAHEKTH------SPLKP----------------YG---CEECGKSYRLISLLNLHKK 398

  Fly   443 MHCKPSDQAAVGSNSDVTAGGDVELAKDSSGHCCNTCGKSFPSALEMLAHAEIHARFPPFKCVLC 507
            .|                 .|:..       :.|..|||.|.::..:..|..:|:...|::|..|
Mouse   399 RH-----------------SGEAR-------YRCGDCGKLFTTSGNLKRHQLVHSGQKPYQCDYC 439

  Fly   508 GISFYEEQAIKRHLHTRHPSELNANSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNK 572
            |.||.:..:..|||.|                              |..:|.|.|..|.|.|:..
Mouse   440 GRSFSDPTSKMRHLET------------------------------HDTDKEHKCPHCDKKFNQV 474

  Fly   573 ARLKRHMASH-RDKSVVCEVCQEEFPDGRTLSNHRHSHSTTTPGKLFPCLECGKTFGSRSSQQIH 636
            ..||.|:..| .|..:.|..|.::|.....|..|...||...|   :.|..|.:.|....:.|.|
Mouse   475 GNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKP---YVCTHCQRQFADPGALQRH 536

  Fly   637 VRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLD 701
            |||||||:|..|..|.|||....:|..|.|.|||||||.|..|.:.|.|...|..||| ||..:
Mouse   537 VRIHTGEKPCQCVICGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANHIR-HHDNI- 599

  Fly   702 VARNTYHCTVCSEDLASSNDLIQHLIQHSDSNTAKQRQPVTGPRKY---------KRRRKLQPH- 756
               ..:.|:|||:...:..||.:|:|.|            ||.:.|         .|...|:.|
Mouse   600 ---RPHKCSVCSKAFVNVGDLSKHIIIH------------TGEKPYLCDKCGRGFNRVDNLRSHV 649

  Fly   757 EIAHMRAANKHVNGDEEEAIGEGDAEECASDIDFCDFDVENVDDIFDMAES-------------P 808
            :..|...|...:...||..                :..|..|||:..:|..             |
Mouse   650 KTVHQGKAGIKILEPEEGG----------------EVSVVTVDDMVTLATEALAATAVTQLTVVP 698

  Fly   809 KKEKRKRGSAATKADAKPVTNGKAAKPAQDKGKAKPR------YDSTSSQ--QSDRLWEEKFLHD 865
            .       .||..||...|...:.:|..:...:..|.      .||...:  .::.|.:...:|.
Mouse   699 V-------GAAVTADETEVLKAEISKAVKQVQEEDPNTHILYACDSCGDKFLDANSLAQHVRIHT 756

  Fly   866 SQ-VALFQIDSLVVVNDTHLQ--PASSAVSANIPNTRGGSKQQGKVQAKSVEGAENLNSSATTSD 927
            :| :.:||.|:     |.:.|  |.|:..:       |...|.|::..:..:|.|...:.|.:..
Mouse   757 AQALVMFQTDA-----DFYQQYGPGSTWPA-------GQMLQAGELVFRPRDGTEGQPTLAESPP 809

  Fly   928 T 928
            |
Mouse   810 T 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7987	NP_650375.1	C2H2 Zn finger	142..162	CDD:275368	3/16 (19%)
		C2H2 Zn finger	170..186	CDD:275368	4/25 (16%)
		COG5048	326..734	CDD:227381	120/436 (28%)
		C2H2 Zn finger	343..363	CDD:275368	5/19 (26%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		C2H2 Zn finger	424..444	CDD:275368	9/19 (47%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		C2H2 Zn finger	504..523	CDD:275368	8/18 (44%)
		C2H2 Zn finger	534..554	CDD:275370	0/19 (0%)
		C2H2 Zn finger	562..582	CDD:275370	7/19 (37%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		C2H2 Zn finger	620..640	CDD:275368	7/19 (37%)
		C2H2 Zn finger	648..668	CDD:275368	8/19 (42%)
		zf-H2C2_2	661..685	CDD:290200	13/23 (57%)
		C2H2 Zn finger	676..696	CDD:275368	8/19 (42%)
		C2H2 Zn finger	709..726	CDD:275371	6/16 (38%)
		Hph	921..>1017	CDD:290417	2/8 (25%)
Zbtb17	NP_001365755.1	BTB_POZ_ZBTB17_MIZ1	2..113	CDD:349515	15/74 (20%)
		PRK07003	<115..>266	CDD:235906	29/154 (19%)
		COG5048	322..653	CDD:227381	121/429 (28%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		C2H2 Zn finger	352..372	CDD:275368	6/19 (32%)
		C2H2 Zn finger	380..400	CDD:275368	9/19 (47%)
		C2H2 Zn finger	408..428	CDD:275368	6/19 (32%)
		C2H2 Zn finger	436..456	CDD:275368	9/49 (18%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	8/19 (42%)
		C2H2 Zn finger	576..596	CDD:275368	8/20 (40%)
		C2H2 Zn finger	604..624	CDD:275368	8/19 (42%)
		C2H2 Zn finger	632..651	CDD:275370	3/18 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100